Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | phosphodiesterase 4D, cAMP-specific | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | glutamate receptor ionotropic kainate 3 | 0.0697 | 0.4836 | 0.4836 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.0629 | 0.3969 | 1 |
Echinococcus multilocularis | NMDA receptor | 0.0697 | 0.4836 | 0.4836 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0723 | 0.5164 | 0.5164 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0723 | 0.5164 | 0.5164 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.1104 | 1 | 1 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0496 | 0.228 | 0.228 |
Echinococcus granulosus | glutamate receptor 2 | 0.0539 | 0.2832 | 0.2832 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.1104 | 1 | 1 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.1104 | 1 | 1 |
Schistosoma mansoni | glutamate receptor kainate | 0.101 | 0.8805 | 1 |
Echinococcus multilocularis | glutamate receptor ionotropic kainate | 0.0697 | 0.4836 | 0.4836 |
Echinococcus granulosus | glutamate receptor 2 | 0.0723 | 0.5164 | 0.5164 |
Brugia malayi | Glutamate receptor 1 precursor | 0.0629 | 0.3969 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.1104 | 1 | 1 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0539 | 0.2832 | 0.2832 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0723 | 0.5164 | 0.5164 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.1104 | 1 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0697 | 0.4836 | 0.4836 |
Echinococcus granulosus | glutamate receptor ionotropic kainate | 0.0697 | 0.4836 | 0.4836 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0496 | 0.228 | 0.228 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0629 | 0.3969 | 0.3969 |
Brugia malayi | Glutamate receptor 2 precursor | 0.0629 | 0.3969 | 0.5 |
Schistosoma mansoni | glutamate receptor NMDA | 0.059 | 0.3475 | 0.1832 |
Schistosoma mansoni | glutamate receptor kainate | 0.101 | 0.8805 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.2 uM | Inhibition of phosphodiesterase type 4 isozyme (PDE4) from the U937 human cell line. | ChEMBL. | 11123995 |
IC50 (binding) | = 0.2 uM | Inhibition of phosphodiesterase type 4 isozyme (PDE4) from the U937 human cell line. | ChEMBL. | 11123995 |
IC50 (binding) | = 53.9 uM | Inhibition of phosphodiesterase 3 (PDE3) isolated from the dog aorta | ChEMBL. | 11123995 |
IC50 (binding) | = 53.9 uM | Inhibition of phosphodiesterase 3 (PDE3) isolated from the dog aorta | ChEMBL. | 11123995 |
IC50 (binding) | = 90.7 uM | Inhibition of phosphodiesterase 1/5 isozyme (PDE1/5) mixture isolated from the guinea pig trachea. | ChEMBL. | 11123995 |
IC50 (binding) | = 90.7 uM | Inhibition of phosphodiesterase 1/5 isozyme (PDE1/5) mixture isolated from the guinea pig trachea. | ChEMBL. | 11123995 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.