Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | lipoprotein LpqF | 0.0802 | 0.4579 | 0.4571 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0801 | 0.4568 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.007 | 0.0014 | 0.003 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0801 | 0.4568 | 1 |
Mycobacterium tuberculosis | Probable conserved lipoprotein LpqF | 0.0802 | 0.4579 | 0.4571 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.068 | 0.3819 | 0.381 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.0239 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.0239 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0107 | 0.0239 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.0239 | 1 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0107 | 0.0239 | 0.0225 |
Loa Loa (eye worm) | beta-lactamase | 0.0107 | 0.0239 | 1 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.007 | 0.0014 | 0.003 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0107 | 0.0239 | 0.5 |
Trypanosoma brucei | beta lactamase | 0.0802 | 0.4579 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0107 | 0.0239 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.0239 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0107 | 0.0239 | 0.0225 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0107 | 0.0239 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0107 | 0.0239 | 1 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0107 | 0.0239 | 0.0225 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0107 | 0.0239 | 0.5 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.007 | 0.0014 | 0.003 |
Mycobacterium ulcerans | class a beta-lactamase, BlaC | 0.1671 | 1 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0107 | 0.0239 | 0.0225 |
Trichomonas vaginalis | esterase, putative | 0.0107 | 0.0239 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0107 | 0.0239 | 0.5 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0107 | 0.0239 | 0.0225 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0107 | 0.0239 | 0.0523 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0107 | 0.0239 | 0.0225 |
Mycobacterium leprae | PROBABLE CONSERVED LIPOPROTEIN LPQF | 0.0802 | 0.4579 | 1 |
Onchocerca volvulus | 0.0107 | 0.0239 | 0.5 | |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0107 | 0.0239 | 0.0225 |
Mycobacterium ulcerans | hypothetical protein | 0.0107 | 0.0239 | 0.0225 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0107 | 0.0239 | 0.0225 |
Toxoplasma gondii | ABC1 family protein | 0.0107 | 0.0239 | 1 |
Onchocerca volvulus | 0.0107 | 0.0239 | 0.5 | |
Mycobacterium tuberculosis | Conserved protein | 0.0107 | 0.0239 | 0.0225 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.0239 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0107 | 0.0239 | 0.5 |
Brugia malayi | beta-lactamase family protein | 0.0107 | 0.0239 | 1 |
Mycobacterium ulcerans | beta-lactamase | 0.0107 | 0.0239 | 0.0225 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0107 | 0.0239 | 0.0225 |
Mycobacterium ulcerans | lipase LipD | 0.0107 | 0.0239 | 0.0225 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.007 | 0.0014 | 0.003 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0107 | 0.0239 | 1 |
Onchocerca volvulus | 0.0107 | 0.0239 | 0.5 | |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0107 | 0.0239 | 0.0225 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0801 | 0.4568 | 1 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0107 | 0.0239 | 0.0225 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0107 | 0.0239 | 0.0523 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.0239 | 1 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0107 | 0.0239 | 0.0523 |
Brugia malayi | beta-lactamase family protein | 0.0107 | 0.0239 | 1 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0107 | 0.0239 | 1 |
Brugia malayi | beta-lactamase | 0.0107 | 0.0239 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0107 | 0.0239 | 0.5 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0107 | 0.0239 | 0.0523 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 26 uM | Tested in vitro for anti-leishmanial activity against Leishmania donovani | ChEMBL. | 9822551 |
IC50 (functional) | = 26 uM | Tested in vitro for anti-leishmanial activity against Leishmania donovani | ChEMBL. | 9822551 |
IC50 (functional) | = 41 uM | Inhibitory activity against phytohemmagglutinin A-induced proliferation of human lymphocytes | ChEMBL. | 9822551 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.