Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0074 | 0.025 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0436 | 1 | 1 |
Toxoplasma gondii | facilitative glucose transporter GT1 | 0.0208 | 0.3853 | 0.5 |
Leishmania major | glucose transporter, lmgt2 | 0.0064 | 0 | 0.5 |
Trypanosoma cruzi | hexose transporter, putative | 0.0064 | 0 | 0.5 |
Trypanosoma brucei | glucose transporter, putative | 0.0064 | 0 | 0.5 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0208 | 0.3853 | 0.3696 |
Trypanosoma brucei | glucose transporter, putative | 0.0064 | 0 | 0.5 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0074 | 0.025 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0436 | 1 | 1 |
Onchocerca volvulus | 0.0074 | 0.025 | 0.5 | |
Trypanosoma brucei | THT1 - hexose transporter, putative | 0.0064 | 0 | 0.5 |
Echinococcus granulosus | General substrate transporter | 0.0178 | 0.3068 | 0.289 |
Plasmodium falciparum | hexose transporter | 0.0208 | 0.3853 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0436 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0436 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0436 | 1 | 1 |
Schistosoma mansoni | glucose transport protein | 0.0208 | 0.3853 | 0.3696 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0074 | 0.025 | 0.0649 |
Trypanosoma cruzi | hexose transporter, putative | 0.0064 | 0 | 0.5 |
Leishmania major | glucose transporter, lmgt3 | 0.0064 | 0 | 0.5 |
Echinococcus multilocularis | General substrate transporter | 0.0178 | 0.3068 | 0.289 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0436 | 1 | 1 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0208 | 0.3853 | 0.3696 |
Schistosoma mansoni | glucose transport protein | 0.0208 | 0.3853 | 0.3696 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0208 | 0.3853 | 0.3696 |
Trypanosoma cruzi | hexose transporter, putative | 0.0064 | 0 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0436 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0074 | 0.025 | 0.5 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0208 | 0.3853 | 0.3696 |
Onchocerca volvulus | 0.0074 | 0.025 | 0.5 | |
Schistosoma mansoni | glucose transport protein | 0.0208 | 0.3853 | 0.3696 |
Leishmania major | glucose transporter/membrane transporter D2, putative | 0.0064 | 0 | 0.5 |
Loa Loa (eye worm) | sugar transporter | 0.0208 | 0.3853 | 0.3696 |
Trypanosoma brucei | glucose transporter 2A | 0.0064 | 0 | 0.5 |
Trypanosoma brucei | glucose transporter, putative | 0.0064 | 0 | 0.5 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0208 | 0.3853 | 0.3696 |
Trypanosoma brucei | glucose transporter, putative | 0.0064 | 0 | 0.5 |
Onchocerca volvulus | 0.0074 | 0.025 | 0.5 | |
Echinococcus multilocularis | acetylcholinesterase | 0.0436 | 1 | 1 |
Trypanosoma brucei | glucose transporter, putative | 0.0064 | 0 | 0.5 |
Trypanosoma cruzi | hexose transporter | 0.0064 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0208 | 0.3853 | 0.3696 |
Echinococcus granulosus | carboxylesterase 5A | 0.0436 | 1 | 1 |
Brugia malayi | Sugar transporter family protein | 0.0208 | 0.3853 | 0.3696 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0208 | 0.3853 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0436 | 1 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0074 | 0.025 | 0.5 |
Onchocerca volvulus | 0.0074 | 0.025 | 0.5 | |
Trypanosoma brucei | THT1 - hexose transporter, putative | 0.0064 | 0 | 0.5 |
Trypanosoma brucei | glucose transporter 1E | 0.0064 | 0 | 0.5 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0074 | 0.025 | 0.0649 |
Plasmodium vivax | hexose transporter | 0.0208 | 0.3853 | 0.5 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0208 | 0.3853 | 0.3696 |
Leishmania major | glucose transporter, lmgt1 | 0.0064 | 0 | 0.5 |
Trypanosoma brucei | glucose transporter, putative | 0.0064 | 0 | 0.5 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0208 | 0.3853 | 0.3696 |
Trypanosoma brucei | THT1 - hexose transporter, putative | 0.0064 | 0 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0074 | 0.025 | 0.5 |
Echinococcus multilocularis | solute carrier family 2, facilitated glucose | 0.0208 | 0.3853 | 0.3696 |
Brugia malayi | Carboxylesterase family protein | 0.0436 | 1 | 1 |
Trypanosoma brucei | glucose transporter, putative | 0.0064 | 0 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0436 | 1 | 1 |
Trypanosoma brucei | glucose transporter, putative | 0.0064 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | > 10000 nM | Binding affinity against 5-hydroxytryptamine 2 receptor in rat using [3H]-ketanserin as radioligand | ChEMBL. | 1479590 |
Ki (binding) | > 10000 nM | Binding affinity against 5-hydroxytryptamine 1C receptor in rat using [3H]-mesulergine as radioligand | ChEMBL. | 1479590 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.