Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0586 | 0.0721 | 0.2495 |
Schistosoma mansoni | inositol monophosphatase | 0.0043 | 0.0011 | 0.0037 |
Loa Loa (eye worm) | hypothetical protein | 0.2246 | 0.2891 | 0.2891 |
Schistosoma mansoni | hypothetical protein | 0.0586 | 0.0721 | 0.2495 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0547 | 0.067 | 0.2318 |
Loa Loa (eye worm) | hypothetical protein | 0.166 | 0.2125 | 0.2125 |
Schistosoma mansoni | hypothetical protein | 0.0586 | 0.0721 | 0.2495 |
Mycobacterium leprae | probable zinc metalloprotease | 0.2246 | 0.2891 | 1 |
Schistosoma mansoni | endothelin-converting enzyme-related | 0.0547 | 0.067 | 0.2318 |
Loa Loa (eye worm) | inositol-1 | 0.0043 | 0.0011 | 0.0011 |
Loa Loa (eye worm) | hypothetical protein | 0.1113 | 0.141 | 0.141 |
Toxoplasma gondii | peptidase family M13 protein | 0.2246 | 0.2891 | 1 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.2246 | 0.2891 | 1 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0043 | 0.0011 | 0.5 |
Brugia malayi | Hypothetical zinc metalloproteinase T16A9.4 | 0.2246 | 0.2891 | 0.2891 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0043 | 0.0011 | 0.0037 |
Loa Loa (eye worm) | hypothetical protein | 0.1699 | 0.2176 | 0.2176 |
Schistosoma mansoni | family M13 non-peptidase homologue (M13 family) | 0.1133 | 0.1436 | 0.4968 |
Mycobacterium ulcerans | zinc metalloprotease | 0.2246 | 0.2891 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1699 | 0.2176 | 0.2176 |
Trichomonas vaginalis | set domain proteins, putative | 0.0274 | 0.0313 | 1 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0241 | 0.0269 | 0.0269 |
Brugia malayi | Pre-SET motif family protein | 0.0241 | 0.0269 | 0.0269 |
Loa Loa (eye worm) | hypothetical protein | 0.1699 | 0.2176 | 0.2176 |
Loa Loa (eye worm) | hypothetical protein | 0.2246 | 0.2891 | 0.2891 |
Loa Loa (eye worm) | hypothetical protein | 0.166 | 0.2125 | 0.2125 |
Brugia malayi | peptidase family M13 containing protein | 0.0547 | 0.067 | 0.067 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0043 | 0.0011 | 0.5 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0586 | 0.0721 | 0.2495 |
Onchocerca volvulus | 0.0274 | 0.0313 | 0.222 | |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.166 | 0.2125 | 0.2125 |
Schistosoma mansoni | hypothetical protein | 0.0586 | 0.0721 | 0.2495 |
Loa Loa (eye worm) | hypothetical protein | 0.1699 | 0.2176 | 0.2176 |
Echinococcus multilocularis | endothelin converting enzyme 1 | 0.2246 | 0.2891 | 1 |
Schistosoma mansoni | Nep2 peptidase (M13 family) | 0.1133 | 0.1436 | 0.4968 |
Loa Loa (eye worm) | hypothetical protein | 0.166 | 0.2125 | 0.2125 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0547 | 0.067 | 0.2318 |
Mycobacterium tuberculosis | Probable zinc metalloprotease Zmp1 | 0.2246 | 0.2891 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1699 | 0.2176 | 0.2176 |
Loa Loa (eye worm) | zinc metallopeptidase 4 | 0.0547 | 0.067 | 0.067 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0043 | 0.0011 | 0.5 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0043 | 0.0011 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0586 | 0.0721 | 0.2495 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.166 | 0.2125 | 0.2125 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.1133 | 0.1436 | 0.4968 |
Loa Loa (eye worm) | hypothetical protein | 0.166 | 0.2125 | 0.2125 |
Schistosoma mansoni | family M13 non-peptidase homologue (M13 family) | 0.0547 | 0.067 | 0.2318 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0043 | 0.0011 | 0.5 |
Loa Loa (eye worm) | angiotensin-converting enzyme family protein | 0.7684 | 1 | 1 |
Schistosoma mansoni | neprilysin | 0.0586 | 0.0721 | 0.2495 |
Brugia malayi | Peptidase family M13 containing protein | 0.2246 | 0.2891 | 0.2891 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0043 | 0.0011 | 0.0037 |
Schistosoma mansoni | inositol monophosphatase | 0.0043 | 0.0011 | 0.0037 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0547 | 0.067 | 0.2318 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0043 | 0.0011 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2246 | 0.2891 | 0.2891 |
Plasmodium vivax | SET domain protein, putative | 0.0035 | 0 | 0.5 |
Schistosoma mansoni | neprilysin-2 (M13 family) | 0.1133 | 0.1436 | 0.4968 |
Loa Loa (eye worm) | hypothetical protein | 0.1699 | 0.2176 | 0.2176 |
Onchocerca volvulus | 0.1113 | 0.141 | 1 | |
Brugia malayi | Inositol-1 | 0.0043 | 0.0011 | 0.0011 |
Schistosoma mansoni | hypothetical protein | 0.0586 | 0.0721 | 0.2495 |
Echinococcus granulosus | endothelin converting enzyme 1 | 0.2246 | 0.2891 | 1 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.1133 | 0.1436 | 0.4968 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0043 | 0.0011 | 0.0037 |
Schistosoma mansoni | endothelin-converting enzyme-like 1 (damage-induced neuronal endopeptidase) | 0.0547 | 0.067 | 0.2318 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 112.5 mg kg-1 | Ability to reinduce anesthesia in mice as a measure of in vivo sedative-hypnotic activity | ChEMBL. | 7241505 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.