TDR Targets

Basic information

Technical information

TDR Targets ID: 251480
Name: 4-(1,3-dimethyl-2-oxoimidazo[4,5-g]quinazolin -8-yl)-N-(4-phenoxyphenyl)piperazine-1-carbox amide
MW: 509.559 | Formula: C28H27N7O3
H donors: 1 H acceptors: 4 LogP: 3.19 Rotable bonds: 6
Rule of 5 violations (Lipinski): 2
SMILES: O=C(N1CCN(CC1)c1ncnc2c1cc1c(c2)n(c(=O)n1C)C)Nc1ccc(cc1)Oc1ccccc1
InChi: 1S/C28H27N7O3/c1-32-24-16-22-23(17-25(24)33(2)28(32)37)29-18-30-26(22)34-12-14-35(15-13-34)27(36)31-19-8-10-21(11-9-19)38-20-6-4-3-5-7-20/h3-11,16-18H,12-15H2,1-2H3,(H,31,36)
InChiKey: KMUWSIMUXBVXPU-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

4-(1,3-dimethyl-2-oxo-imidazo[4,5-g]quinazolin-8-yl)-N-(4-phenoxyphenyl)piperazine-1-carboxamide
4-(1,3-dimethyl-2-oxo-8-imidazo[4,5-g]quinazolinyl)-N-(4-phenoxyphenyl)-1-piperazinecarboxamide
4-(2-keto-1,3-dimethyl-imidazo[4,5-g]quinazolin-8-yl)-N-(4-phenoxyphenyl)piperazine-1-carboxamide
4-(1,3-dimethyl-2-oxopyrimido[6,5-f]benzimidazol-8-yl)-N-[4-(phenoxy)phenyl]piperazine-1-carboxamide
4-(1,3-dimethyl-2-oxo-pyrimido[6,5-f]benzimidazol-8-yl)-N-[4-(phenoxy)phenyl]piperazine-1-carboxamide
4-(1,3-dimethyl-2-oxo-8-pyrimido[6,5-f]benzimidazolyl)-N-[4-(phenoxy)phenyl]-1-piperazinecarboxamide
4-(2-keto-1,3-dimethyl-pyrimido[6,5-f]benzimidazol-8-yl)-N-[4-(phenoxy)phenyl]piperazine-1-carboxamide

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	platelet-derived growth factor receptor, beta polypeptide	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	GPCR, family 2	0.0018	0.0015	0.0002
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0018	0.0015	0.0015
Trypanosoma brucei	cdc2-related kinase 3	0.0195	0.0836	0.2344
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0133	0.0547	0.2068
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.027	0.1182	0.117
Entamoeba histolytica	cyclin family protein	0.0425	0.19	0.7783
Trichomonas vaginalis	cyclin A, putative	0.0102	0.0406	0.0274
Loa Loa (eye worm)	CYL-1 protein	0.0102	0.0406	0.0464
Echinococcus multilocularis	cyclin b3	0.0425	0.19	0.189
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.027	0.1182	0.1182
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0058	0.0198	0.0221
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 3	0.0133	0.0547	0.1178
Schistosoma mansoni	hypothetical protein	0.0018	0.0015	0.0015
Entamoeba histolytica	cyclin, putative	0.0538	0.2425	1
Trypanosoma cruzi	Eukaryotic translation initiation factor 2-alpha kinase 2	0.009	0.0349	0.0248
Echinococcus granulosus	cAMP dependent protein kinase catalytic subunit	0.0133	0.0547	0.0547
Schistosoma mansoni	serine/threonine protein kinase	0.0133	0.0547	0.0547
Echinococcus granulosus	cyclin k	0.0102	0.0406	0.0406
Plasmodium falciparum	calcium-dependent protein kinase 3	0.027	0.1182	0.6167
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0027	0.0058	1
Trichomonas vaginalis	CMGC family protein kinase	0.0195	0.0836	0.2344
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0102	0.0406	0.0459
Echinococcus granulosus	cyclin B	0.0538	0.2425	0.2425
Plasmodium falciparum	cAMP-dependent protein kinase catalytic subunit	0.0133	0.0547	0.2783
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0027	0.0058	1
Loa Loa (eye worm)	cyclin domain-containing protein	0.0102	0.0406	0.0464
Trypanosoma brucei	cyclin dependent kinase-binding protein, putative	0.0102	0.0406	0.0274
Schistosoma mansoni	g1/s-specific cyclin C	0.0102	0.0406	0.0406
Trichomonas vaginalis	CMGC family protein kinase	0.0195	0.0836	0.2344
Trichomonas vaginalis	cyclin B, putative	0.0538	0.2425	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0013	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0538	0.2425	0.2772
Entamoeba histolytica	cell division protein kinase 2, putative	0.0195	0.0836	0.3287
Loa Loa (eye worm)	cyclin fold protein 1 variant b	0.0102	0.0406	0.0464
Echinococcus multilocularis	cyclin dependent kinase 1	0.0195	0.0836	0.0824
Loa Loa (eye worm)	hypothetical protein	0.002	0.0026	0.0029
Trichomonas vaginalis	conserved hypothetical protein	0.0425	0.19	0.7472
Trichomonas vaginalis	cyclins, putative	0.0538	0.2425	1
Brugia malayi	Cam kinase protein 1	0.027	0.1182	0.1346
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0058	0.0198	0.0221
Trichomonas vaginalis	cyclin B, putative	0.0538	0.2425	1
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.1902	0.8749	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0013	0.0015
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.0133	0.0547	0.0535
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.2172	1	1
Entamoeba histolytica	cyclin, domain containing protein	0.0102	0.0406	0.1472
Echinococcus multilocularis	oligomeric golgi complex subunit 3	0.0102	0.0406	0.0393
Loa Loa (eye worm)	cyclin domain-containing protein	0.0102	0.0406	0.0464
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 1	0.0133	0.0547	0.1178
Echinococcus granulosus	oligomeric golgi complex subunit 3	0.0102	0.0406	0.0406
Schistosoma mansoni	cyclins	0.0425	0.19	0.19
Trypanosoma cruzi	cyclin 6, putative	0.0538	0.2425	1
Loa Loa (eye worm)	cyclin C	0.0102	0.0406	0.0464
Schistosoma mansoni	hypothetical protein	0.0018	0.0015	0.0015
Entamoeba histolytica	cell division protein kinase 2, putative	0.0195	0.0836	0.3287
Schistosoma mansoni	cyclin d	0.0102	0.0406	0.0406
Echinococcus granulosus	cyclins	0.0425	0.19	0.19
Trypanosoma cruzi	hypothetical protein, conserved	0.0102	0.0406	0.0515
Loa Loa (eye worm)	hypothetical protein	0.002	0.0026	0.0029
Echinococcus multilocularis	G1:S specific cyclin D1	0.0102	0.0406	0.0393
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.027	0.1182	0.7612
Giardia lamblia	G2/mitotic-specific cyclin B	0.0538	0.2425	1
Trichomonas vaginalis	cyclin D, putative	0.0102	0.0406	0.0274
Trichomonas vaginalis	CAMK family protein kinase	0.027	0.1182	0.401
Brugia malayi	hypothetical protein	0.0102	0.0406	0.0459
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0058	0.0066
Echinococcus granulosus	cyclin t1	0.0102	0.0406	0.0406
Echinococcus multilocularis	cyclin B	0.0538	0.2425	0.2415
Toxoplasma gondii	cell-cycle-associated protein kinase CDK, putative	0.0195	0.0836	0.4218
Trichomonas vaginalis	cyclins, putative	0.0538	0.2425	1
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0018	0.0014	0.0016
Trichomonas vaginalis	cyclins, putative	0.0102	0.0406	0.0274
Schistosoma mansoni	hypothetical protein	0.0018	0.0015	0.0015
Entamoeba histolytica	protein kinase, putative	0.027	0.1182	0.4748
Schistosoma mansoni	serine/threonine protein kinase	0.0133	0.0547	0.0547
Brugia malayi	Protein kinase domain containing protein	0.0195	0.0836	0.0951
Onchocerca volvulus		0.0102	0.0406	0.1472
Echinococcus multilocularis	cyclin G2	0.0102	0.0406	0.0393
Brugia malayi	AMP-binding enzyme family protein	0.0027	0.0058	0.0061
Mycobacterium ulcerans	acyl-CoA synthetase	0.0027	0.0058	1
Trichomonas vaginalis	cyclins, putative	0.0425	0.19	0.7472
Schistosoma mansoni	hypothetical protein	0.0039	0.0113	0.0113
Loa Loa (eye worm)	hypothetical protein	0.002	0.0026	0.0029
Echinococcus granulosus	cyclin G2	0.0102	0.0406	0.0406
Echinococcus granulosus	cyclin B3 1	0.0425	0.19	0.19
Schistosoma mansoni	serine/threonine protein kinase	0.0133	0.0547	0.0547
Leishmania major	cell division related protein kinase 2,cdc2-related kinase	0.0195	0.0836	0.3287
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.002	0.0026	0.5
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0406	0.0464
Loa Loa (eye worm)	hypothetical protein	0.027	0.1182	0.1351
Echinococcus granulosus	cyclin dependent kinase 1	0.0195	0.0836	0.0836
Trypanosoma cruzi	mitotic cyclin, putative	0.0102	0.0406	0.0515
Echinococcus multilocularis	Cyclin L1	0.0102	0.0406	0.0393
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0018	0.0015	0.0015
Leishmania major	protein kinase, putative,eukaryotic translation initiation factor 2-alpha kinase precursor, putative	0.009	0.0349	0.1232
Trichomonas vaginalis	cyclin B, putative	0.0102	0.0406	0.0274
Loa Loa (eye worm)	cyclin domain-containing protein	0.0102	0.0406	0.0464
Trichomonas vaginalis	cyclins, putative	0.0538	0.2425	1
Echinococcus granulosus	cyclin G2	0.0102	0.0406	0.0406
Brugia malayi	Latrophilin receptor protein 2	0.0018	0.0015	0.0012
Trichomonas vaginalis	cyclins, putative	0.0216	0.0931	0.2802
Plasmodium vivax	cAMP-dependent protein kinase catalytic subunit, putative	0.0133	0.0547	0.4512
Schistosoma mansoni	protein kinase	0.2172	1	1
Schistosoma mansoni	hypothetical protein	0.0102	0.0406	0.0406
Schistosoma mansoni	cyclin k	0.0102	0.0406	0.0406
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0133	0.0547	0.2068
Loa Loa (eye worm)	hypothetical protein	0.002	0.0026	0.0029
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0016	0.0005	0.0005
Trypanosoma cruzi	cyclin, putative	0.0538	0.2425	1
Trichomonas vaginalis	CMGC family protein kinase	0.0195	0.0836	0.2344
Trichomonas vaginalis	cyclin B3, putative	0.0425	0.19	0.7472
Echinococcus granulosus	cyclins	0.0425	0.19	0.19
Trypanosoma cruzi	cdc2-related kinase 3	0.0195	0.0836	0.2534
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0058	0.0198	0.0226
Echinococcus granulosus	cyclin y	0.0102	0.0406	0.0406
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0538	0.2425	0.2768
Leishmania major	protein kinase, putative	0.027	0.1182	0.4748
Loa Loa (eye worm)	cyclin domain-containing protein	0.0678	0.3076	0.3516
Trichomonas vaginalis	cyclin B, putative	0.0425	0.19	0.7472
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0102	0.0406	0.0459
Plasmodium falciparum	calcium-dependent protein kinase 1	0.027	0.1182	0.6167
Trypanosoma brucei	cAMP-dependent protein kinase catalytic subunit 1	0.0133	0.0547	0.0954
Trichomonas vaginalis	AGC family protein kinase	0.0133	0.0547	0.0954
Echinococcus granulosus	cyclins	0.0102	0.0406	0.0406
Echinococcus multilocularis	cyclin y	0.0102	0.0406	0.0393
Echinococcus multilocularis	cyclin t1	0.0102	0.0406	0.0393
Echinococcus multilocularis	cyclin y	0.0102	0.0406	0.0393
Echinococcus granulosus	cyclin dependent kinase 5	0.0195	0.0836	0.0836
Loa Loa (eye worm)	hypothetical protein	0.0133	0.0547	0.0626
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0018	0.0015	0.0018
Trypanosoma brucei	cAMP-dependent protein kinase catalytic subunit 2	0.0133	0.0547	0.0954
Loa Loa (eye worm)	hypothetical protein	0.0113	0.0456	0.0521
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0027	0.0058	0.5
Trypanosoma brucei	mitotic cyclin	0.0102	0.0406	0.0274
Plasmodium vivax	protein kinase Crk2	0.0195	0.0836	0.7008
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.027	0.1182	1
Leishmania major	cell division protein kinase 2,cdc2-related kinase	0.0195	0.0836	0.3287
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0678	0.3076	0.3512
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.0133	0.0547	0.0535
Echinococcus granulosus	GPCR family 2	0.0018	0.0015	0.0015
Onchocerca volvulus	Cyclin L homolog	0.0102	0.0406	0.1472
Loa Loa (eye worm)	hypothetical protein	0.0538	0.2425	0.2772
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0406	0.0464
Giardia lamblia	Kinase, AGC PKA	0.0133	0.0547	0.0699
Toxoplasma gondii	AGC kinase	0.0133	0.0547	0.1386
Schistosoma mansoni	serine/threonine protein kinase	0.0195	0.0836	0.0836
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0102	0.0406	0.2029
Echinococcus granulosus	roundabout 2	0.0018	0.0013	0.0013
Trichomonas vaginalis	cyclins, putative	0.0538	0.2425	1
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0102	0.0406	0.0459
Entamoeba histolytica	cyclin, putative	0.0425	0.19	0.7783
Schistosoma mansoni	serine/threonine protein kinase	0.027	0.1182	0.1182
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0058	0.0066
Schistosoma mansoni	protein kinase	0.2172	1	1
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.027	0.1182	0.7612
Plasmodium falciparum	calcium-dependent protein kinase 5	0.027	0.1182	0.6167
Schistosoma mansoni	protein kinase	0.2172	1	1
Leishmania major	mitotic cyclin, putative	0.0102	0.0406	0.1472
Onchocerca volvulus	Cyclin L homolog	0.0102	0.0406	0.1472
Echinococcus multilocularis	cyclin G2	0.0102	0.0406	0.0393
Schistosoma mansoni	cyclin l	0.0102	0.0406	0.0406
Echinococcus granulosus	cAMP dependent protein kinase catalytic subunit	0.0133	0.0547	0.0547
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 2	0.0133	0.0547	0.1178
Echinococcus granulosus	G1:S specific cyclin D1	0.0102	0.0406	0.0406
Brugia malayi	AMP-binding enzyme family protein	0.0027	0.0058	0.0061
Brugia malayi	AMP-binding enzyme family protein	0.0027	0.0058	0.0061
Trypanosoma brucei	protein kinase A catalytic subunit, putative	0.0133	0.0547	0.0954
Echinococcus multilocularis	cyclin dependent kinase 1	0.0195	0.0836	0.0824
Trichomonas vaginalis	conserved hypothetical protein	0.0102	0.0406	0.0274
Leishmania major	protein kinase A catalytic subunit isoform 1	0.0133	0.0547	0.2068
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 3	0.0133	0.0547	0.1178
Leishmania major	protein kinase A catalytic subunit isoform 2	0.0133	0.0547	0.2068
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.027	0.1182	0.401
Plasmodium vivax	serine/threonine protein kinase, putative	0.009	0.0349	0.2799
Brugia malayi	Cyclin C	0.0102	0.0406	0.0459
Plasmodium falciparum	cyclin 1	0.0102	0.0406	0.2029
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0027	0.0058	1
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0195	0.0836	0.0955
Echinococcus multilocularis	cyclin dependent kinase 5	0.0195	0.0836	0.0824
Echinococcus multilocularis	cyclin	0.0102	0.0406	0.0393
Schistosoma mansoni	hypothetical protein	0.0102	0.0406	0.0406
Echinococcus multilocularis	cyclins	0.0425	0.19	0.189
Plasmodium falciparum	protein kinase 5	0.0195	0.0836	0.4322
Trichomonas vaginalis	cyclin B, putative	0.0102	0.0406	0.0274
Trichomonas vaginalis	cyclin B3, putative	0.0102	0.0406	0.0274
Echinococcus multilocularis	cyclins	0.0425	0.19	0.189
Trypanosoma cruzi	cdc2-related kinase 3	0.0195	0.0836	0.2534
Trichomonas vaginalis	cyclin A, putative	0.0538	0.2425	1
Schistosoma mansoni	cyclin B	0.0538	0.2425	0.2425
Trichomonas vaginalis	cyclin D, putative	0.0425	0.19	0.7472
Schistosoma mansoni	cyclin G	0.0102	0.0406	0.0406
Trypanosoma brucei	cdc2-related kinase 1	0.0195	0.0836	0.2344
Loa Loa (eye worm)	CMGC/CDK/CDK5 protein kinase	0.0195	0.0836	0.0955
Mycobacterium ulcerans	hypothetical protein	0.0027	0.0058	1
Trypanosoma cruzi	cyclin 9, putative	0.0102	0.0406	0.0515
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.027	0.1182	1
Echinococcus granulosus	cyclin y	0.0102	0.0406	0.0406
Echinococcus multilocularis	calcium dependent protein kinase	0.0258	0.1129	0.1117
Echinococcus granulosus	cdk5 and abl1 enzyme substrate 1	0.0102	0.0406	0.0406
Plasmodium falciparum	cyclin	0.0425	0.19	1
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.002	0.0026	0.139
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0018	0.0015	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0113	0.013
Onchocerca volvulus	Protein CNPPD1 homolog	0.0102	0.0406	0.1472
Leishmania major	CYC2-like cyclin, putative,cyclin 6, putative	0.0538	0.2425	1
Trypanosoma cruzi	Eukaryotic translation initiation factor 2-alpha kinase 2	0.009	0.0349	0.0248
Schistosoma mansoni	Cyclin fold protein	0.0102	0.0406	0.0406
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.027	0.1182	0.117
Trichomonas vaginalis	conserved hypothetical protein	0.0102	0.0406	0.0274
Echinococcus granulosus	cyclin b3	0.0425	0.19	0.19
Echinococcus granulosus	Cyclin L1	0.0102	0.0406	0.0406
Trichomonas vaginalis	cyclin B3, putative	0.0102	0.0406	0.0274
Trichomonas vaginalis	cyclin B, putative	0.0538	0.2425	1
Echinococcus granulosus	cyclins	0.0425	0.19	0.19
Entamoeba histolytica	protein kinase, putative	0.027	0.1182	0.4748
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.027	0.1182	1
Trichomonas vaginalis	cyclin D, putative	0.0425	0.19	0.7472
Giardia lamblia	Kinase, CMGC CDK	0.0195	0.0836	0.2129
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.027	0.1182	0.117
Brugia malayi	latrophilin 2 splice variant baaae	0.0039	0.0113	0.0124
Echinococcus multilocularis	cyclins	0.0425	0.19	0.189
Plasmodium vivax	cyclin homologue, putative	0.0102	0.0406	0.3291
Echinococcus multilocularis	cyclins	0.0425	0.19	0.189
Loa Loa (eye worm)	AGC/PKA protein kinase	0.0133	0.0547	0.0626
Plasmodium vivax	calcium-dependent protein kinase, putative	0.027	0.1182	1
Entamoeba histolytica	hypothetical protein	0.0102	0.0406	0.1472
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.027	0.1182	0.1182
Trichomonas vaginalis	conserved hypothetical protein	0.0102	0.0406	0.0274
Trypanosoma brucei	cyclin 9	0.0102	0.0406	0.0274
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0102	0.0406	0.0459
Leishmania major	cyclin	0.0538	0.2425	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0015	0.0018
Echinococcus multilocularis	cyclins	0.0425	0.19	0.189
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.0133	0.0547	0.0535
Entamoeba histolytica	cyclin C, putative	0.0102	0.0406	0.1472
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0102	0.0406	0.0459
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0018	0.0015	0.0002
Giardia lamblia	Kinase, CMGC CDK	0.0195	0.0836	0.2129
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.027	0.1182	0.1182
Mycobacterium ulcerans	acyl-CoA synthetase	0.0027	0.0058	1
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase subunit type II alpha	0.1902	0.8749	1
Entamoeba histolytica	cyclin family protein	0.0425	0.19	0.7783
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.027	0.1182	0.1346
Plasmodium vivax	cyclin 4, putative	0.0102	0.0406	0.3291
Trypanosoma brucei	mitotic cyclin 6	0.0538	0.2425	1
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.0133	0.0547	0.0535
Brugia malayi	Cyclin, N-terminal domain containing protein	0.1357	0.6224	0.7113
Echinococcus multilocularis	cdk5 and abl1 enzyme substrate 1	0.0102	0.0406	0.0393
Leishmania major	mitotic cyclin, putative	0.0102	0.0406	0.1472
Toxoplasma gondii	protein kinase, cAMP-dependent, catalytic chain	0.0133	0.0547	0.1386
Brugia malayi	cell division control protein 2 homolog	0.0195	0.0836	0.0951
Giardia lamblia	Cyclin A	0.0425	0.19	0.7401
Trypanosoma cruzi	cyclin, putative	0.0538	0.2425	1
Echinococcus multilocularis	cyclin B3 1	0.0425	0.19	0.189
Toxoplasma gondii	AGC kinase	0.0133	0.0547	0.1386
Echinococcus granulosus	cyclin A3 4	0.0102	0.0406	0.0406
Echinococcus granulosus	twitchin	0.0025	0.0049	0.0049
Trypanosoma cruzi	cdc2-related kinase 1	0.0195	0.0836	0.2534
Leishmania major	cyclin 9, putative	0.0102	0.0406	0.1472
Loa Loa (eye worm)	cyclin domain-containing protein	0.0102	0.0406	0.0464
Entamoeba histolytica	cyclin, domain containing protein	0.0102	0.0406	0.1472
Echinococcus granulosus	enhancer of mRNA decapping protein 4	0.0122	0.0495	0.0495
Trypanosoma brucei	cyclin 3	0.0102	0.0406	0.0274
Echinococcus multilocularis	G2:mitotic specific cyclin B3	0.0678	0.3076	0.3067
Echinococcus multilocularis	cyclin A3 4	0.0102	0.0406	0.0393
Echinococcus granulosus	cyclins	0.0425	0.19	0.19
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0102	0.0406	0.0459
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0018	0.0015	0.0012
Loa Loa (eye worm)	AGC/PKA protein kinase	0.0133	0.0547	0.0626
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0027	0.0058	1
Echinococcus granulosus	calcium dependent protein kinase	0.0258	0.1129	0.1129
Loa Loa (eye worm)	cyclin domain-containing protein	0.1357	0.6224	0.7114
Loa Loa (eye worm)	hypothetical protein	0.0184	0.0783	0.0895
Schistosoma mansoni	hypothetical protein	0.0018	0.0015	0.0015
Plasmodium vivax	cyclin dependent kinase binding protein, putative	0.0102	0.0406	0.3291
Echinococcus multilocularis	cyclins	0.0425	0.19	0.189
Echinococcus multilocularis	cyclin dependent kinase	0.0195	0.0836	0.0824
Brugia malayi	cAMP-dependent protein kinase catalytic subunit, putative	0.0133	0.0547	0.0621
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0538	0.2425	0.2768
Echinococcus granulosus	cAMP dependent protein kinase catalytic subunit	0.0133	0.0547	0.0547
Echinococcus granulosus	cyclin	0.0102	0.0406	0.0406
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0027	0.0058	1
Echinococcus granulosus	5'partial\|cyclin dependent kinase 1	0.0195	0.0836	0.0836
Echinococcus granulosus	cyclin dependent kinase	0.0195	0.0836	0.0836
Brugia malayi	hypothetical protein	0.0102	0.0406	0.0459
Echinococcus granulosus	cyclins	0.0425	0.19	0.19
Giardia lamblia	Hypothetical protein	0.0425	0.19	0.7401
Echinococcus multilocularis	enhancer of mRNA decapping protein 4	0.0122	0.0495	0.0482
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.027	0.1182	0.1351
Trichomonas vaginalis	cyclins, putative	0.0102	0.0406	0.0274
Brugia malayi	cyclin fold protein 1 variant b	0.0102	0.0406	0.0459
Plasmodium falciparum	calcium-dependent protein kinase 4	0.027	0.1182	0.6167
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0198	0.0226
Schistosoma mansoni	cyclin B3	0.0678	0.3076	0.3076
Onchocerca volvulus		0.0538	0.2425	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0027	0.0058	1
Trichomonas vaginalis	cyclin B, putative	0.0538	0.2425	1
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0027	0.0058	1
Schistosoma mansoni	cyclin G2	0.0102	0.0406	0.0406
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.027	0.1182	0.1351
Trypanosoma cruzi	CYC2-like cyclin, putative	0.0538	0.2425	1
Plasmodium falciparum	calcium-dependent protein kinase 2	0.027	0.1182	0.6167
Echinococcus granulosus	G2:mitotic specific cyclin B3	0.0678	0.3076	0.3076
Leishmania major	protein kinase A catalytic subunit	0.0133	0.0547	0.2068
Trichomonas vaginalis	conserved hypothetical protein	0.0102	0.0406	0.0274
Echinococcus multilocularis	cyclins	0.0425	0.19	0.189
Echinococcus multilocularis	cyclin k	0.0102	0.0406	0.0393
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0027	0.0058	0.5
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.027	0.1182	0.7612
Plasmodium vivax	hypothetical protein, conserved	0.0102	0.0406	0.3291
Trypanosoma cruzi	cdc2-related kinase 1	0.0195	0.0836	0.2534
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0058	0.0066
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0195	0.0836	0.0955
Schistosoma mansoni	proteasome subunit alpha 1 (T01 family)	0.0102	0.0406	0.0406
Loa Loa (eye worm)	hypothetical protein	0.002	0.0026	0.0029
Schistosoma mansoni	serine/threonine protein kinase	0.0195	0.0836	0.0836
Loa Loa (eye worm)	cyclin domain-containing protein	0.0102	0.0406	0.0464
Plasmodium falciparum	cyclin dependent kinase binding protein, putative	0.0102	0.0406	0.2029
Toxoplasma gondii	hypothetical protein	0.0322	0.1425	1
Trypanosoma cruzi	mitotic cyclin, putative	0.0102	0.0406	0.0515

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.1 uM	Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent assay (ELISA)	ChEMBL.	14584942
IC50 (binding)	= 0.1 uM	Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent assay (ELISA)	ChEMBL.	14584942

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

PubChem: 11156466

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 251480