Detailed information for compound 25209

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 621.572 | Formula: C23H37N6O14+
  • H donors: 11 H acceptors: 12 LogP: -7.01 Rotable bonds: 17
    Rule of 5 violations (Lipinski): 4
  • SMILES: OCc1cn(c(=O)[nH]c1=O)C1OC(C(C1O)O)[C@H](C(=O)O)NC(=O)[C@H]([C@H]([C@H](COC(=O)N)O)O)NC(=O)[C@H](CC(C)C)[NH3+]
  • InChi: 1S/C23H36N6O14/c1-7(2)3-9(24)18(36)26-11(13(32)10(31)6-42-22(25)40)19(37)27-12(21(38)39)16-14(33)15(34)20(43-16)29-4-8(5-30)17(35)28-23(29)41/h4,7,9-16,20,30-34H,3,5-6,24H2,1-2H3,(H2,25,40)(H,26,36)(H,27,37)(H,38,39)(H,28,35,41)/p+1/t9-,10-,11-,12-,13+,14?,15?,16?,20?/m0/s1
  • InChiKey: MGXBZOYKQLKVNR-DNYKHZOLSA-O  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0032 0.0015 0.0022
Trypanosoma brucei FAD dependent oxidoreductase, putative 0.0174 0.0703 1
Brugia malayi TAR-binding protein 0.0135 0.0513 0.6034
Brugia malayi G protein-coupled receptor F59B2.13 0.007 0.0199 0.2228
Loa Loa (eye worm) hypothetical protein 0.007 0.0199 0.0199
Schistosoma mansoni biogenic amine (5HT) receptor 0.007 0.0199 0.0184
Brugia malayi Papain family cysteine protease containing protein 0.0036 0.0032 0.021
Echinococcus multilocularis rhodopsin orphan GPCR 0.007 0.0199 0.0288
Echinococcus granulosus rhodopsin orphan GPCR 0.007 0.0199 0.0288
Echinococcus multilocularis cysteine protease 0.0036 0.0032 0.0047
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.007 0.0199 0.0184
Echinococcus granulosus rhodopsin orphan GPCR 0.007 0.0199 0.0288
Schistosoma mansoni cathepsin F (C01 family) 0.0036 0.0032 0.0017
Echinococcus granulosus lamin 0.0061 0.0153 0.0221
Loa Loa (eye worm) hypothetical protein 0.007 0.0199 0.0199
Echinococcus granulosus rhodopsin orphan GPCR 0.007 0.0199 0.0288
Loa Loa (eye worm) steroid hormone receptor 0.0032 0.0015 0.0015
Brugia malayi Latrophilin receptor protein 2 0.0064 0.0169 0.1861
Schistosoma mansoni amine GPCR 0.007 0.0199 0.0184
Toxoplasma gondii hypothetical protein 0.0174 0.0703 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0061 0.0153 0.0153
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.0032 0.5
Onchocerca volvulus 0.007 0.0199 0.2105
Schistosoma mansoni neuropeptide receptor 0.007 0.0199 0.0184
Echinococcus multilocularis cysteine protease 0.0036 0.0032 0.0047
Schistosoma mansoni neuropeptide receptor 0.007 0.0199 0.0184
Schistosoma mansoni rhodopsin-like orphan GPCR 0.007 0.0199 0.0184
Schistosoma mansoni biogenic amine receptor 0.007 0.0199 0.0184
Echinococcus multilocularis G-protein coupled receptor, putative 0.007 0.0199 0.0288
Brugia malayi ORL1-like opioid receptor 0.007 0.0199 0.2228
Echinococcus multilocularis neuropeptide receptor A26 0.007 0.0199 0.0288
Onchocerca volvulus 0.007 0.0199 0.2105
Echinococcus multilocularis alpha 1A adrenergic receptor 0.007 0.0199 0.0288
Brugia malayi hypothetical protein 0.007 0.0199 0.2228
Loa Loa (eye worm) hypothetical protein 0.0032 0.0015 0.0015
Brugia malayi gonadotropin-releasing hormone receptor 2 0.007 0.0199 0.2228
Brugia malayi glutathione reductase 0.005 0.0101 0.104
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0015 0.0022
Brugia malayi hypothetical protein 0.0106 0.0372 0.4318
Trypanosoma cruzi L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative 0.0174 0.0703 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0137 0.0523 0.7015
Echinococcus multilocularis fmrfamide receptor 0.007 0.0199 0.0288
Loa Loa (eye worm) hypothetical protein 0.007 0.0199 0.0199
Echinococcus granulosus neuropeptide receptor 0.1211 0.5735 0.8306
Brugia malayi hypothetical protein 0.007 0.0199 0.2228
Onchocerca volvulus 0.007 0.0199 0.2105
Echinococcus granulosus alpha 1A adrenergic receptor 0.007 0.0199 0.0288
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.007 0.0199 0.0184
Trypanosoma cruzi major cysteine proteinase, putative 0.0108 0.0381 0.5196
Chlamydia trachomatis D-amino acid dehydrogenase 0.0174 0.0703 0.5
Onchocerca volvulus 0.0036 0.0032 0.0198
Loa Loa (eye worm) hypothetical protein 0.007 0.0199 0.0199
Echinococcus granulosus lamin dm0 0.0061 0.0153 0.0221
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0047 0.0088 0.0128
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0137 0.0523 0.7015
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0137 0.0523 0.7015
Loa Loa (eye worm) hypothetical protein 0.007 0.0199 0.0199
Schistosoma mansoni biogenic amine receptor 0.007 0.0199 0.0184
Brugia malayi Cathepsin L-like precursor 0.0036 0.0032 0.021
Brugia malayi Cathepsin L-like precursor 0.0036 0.0032 0.021
Leishmania major trypanothione reductase 0.005 0.0101 0.1022
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0114 0.0413 0.0344
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0064 0.0169 0.1861
Echinococcus multilocularis microtubule associated protein 2 0.1427 0.6786 0.9828
Echinococcus granulosus peptide allatostatin:somatostatin 0.007 0.0199 0.0288
Loa Loa (eye worm) thioredoxin reductase 0.005 0.0101 0.0101
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0114 0.0413 0.0344
Loa Loa (eye worm) hypothetical protein 0.0032 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.007 0.0199 0.0199
Loa Loa (eye worm) hypothetical protein 0.007 0.0199 0.0199
Brugia malayi hypothetical protein 0.007 0.0199 0.2228
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0127 0.0475 0.0413
Mycobacterium tuberculosis Probable D-amino acid oxidase Aao 0.1915 0.9155 1
Onchocerca volvulus 0.007 0.0199 0.2105
Trypanosoma cruzi cysteine peptidase, putative 0.0137 0.0523 0.732
Onchocerca volvulus 0.007 0.0199 0.2105
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0064 0.0169 0.0244
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.007 0.0199 0.0288
Loa Loa (eye worm) hypothetical protein 0.0174 0.0703 0.0703
Echinococcus granulosus 7TM GPCR rhodopsin 0.007 0.0199 0.0288
Brugia malayi hypothetical protein 0.007 0.0199 0.2228
Brugia malayi Cathepsin L-like precursor 0.0036 0.0032 0.021
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.007 0.0199 0.0288
Echinococcus granulosus sex peptide receptor 0.007 0.0199 0.0288
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.007 0.0199 0.2228
Echinococcus multilocularis geminin 0.0166 0.0664 0.0961
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0064 0.0169 0.0244
Loa Loa (eye worm) hypothetical protein 0.007 0.0199 0.0199
Echinococcus multilocularis g protein coupled receptor 0.007 0.0199 0.0288
Loa Loa (eye worm) ctsf protein 0.0036 0.0032 0.0032
Schistosoma mansoni microtubule-associated protein tau 0.1427 0.6786 0.6781
Leishmania major hypothetical protein, conserved 0.0174 0.0703 1
Brugia malayi hypothetical protein 0.007 0.0199 0.2228
Schistosoma mansoni myosin xvIII 0.007 0.0199 0.0184
Loa Loa (eye worm) RNA binding protein 0.0135 0.0513 0.0513
Schistosoma mansoni tar DNA-binding protein 0.0135 0.0513 0.0499
Plasmodium vivax glutathione reductase, putative 0.005 0.0101 0.1022
Schistosoma mansoni amine GPCR 0.007 0.0199 0.0184
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0137 0.0523 0.7015
Schistosoma mansoni hypothetical protein 0.0166 0.0664 0.0649
Brugia malayi AKH receptor 0.007 0.0199 0.2228
Echinococcus multilocularis tumor protein p63 0.1452 0.6905 1
Echinococcus multilocularis orexin receptor type 2 0.007 0.0199 0.0288
Echinococcus granulosus neuropeptide receptor A26 0.007 0.0199 0.0288
Onchocerca volvulus 0.0036 0.0032 0.0198
Loa Loa (eye worm) intermediate filament protein 0.0061 0.0153 0.0153
Loa Loa (eye worm) hypothetical protein 0.0064 0.0169 0.0169
Loa Loa (eye worm) hypothetical protein 0.007 0.0199 0.0199
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0137 0.0523 0.7015
Echinococcus granulosus glycerol 3 phosphate dehydrogenase 0.0174 0.0703 0.1018
Onchocerca volvulus Neuropeptide F receptor homolog 0.007 0.0199 0.2105
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.007 0.0199 0.0288
Leishmania major cathepsin L-like protease 0.0137 0.0523 0.732
Loa Loa (eye worm) melatonin receptor type 1A 0.007 0.0199 0.0199
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.007 0.0199 0.0184
Brugia malayi Dopamine receptor protein 2 0.007 0.0199 0.2228
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.007 0.0199 0.0199
Schistosoma mansoni amine GPCR 0.007 0.0199 0.0184
Echinococcus granulosus somatostatin receptor 0.007 0.0199 0.0288
Echinococcus multilocularis neuropeptide Y receptor 0.007 0.0199 0.0288
Brugia malayi Melatonin receptor type 1A 0.007 0.0199 0.2228
Echinococcus multilocularis g protein coupled receptor 0.007 0.0199 0.0288
Mycobacterium leprae Probable cholesterol oxidase precursor ChoD (cholesterol-O2 oxidoreductase) 0.0174 0.0703 0.0303
Trypanosoma brucei glycerol-3-phosphate dehydrogenase (FAD-dependent), putative 0.0174 0.0703 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.007 0.0199 0.2228
Loa Loa (eye worm) hypothetical protein 0.007 0.0199 0.0199
Echinococcus multilocularis sterol O acyltransferase 1 0.0227 0.096 0.139
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0032 0.0015 0.0015
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0032 0.0015 0.0015
Schistosoma mansoni tar DNA-binding protein 0.0135 0.0513 0.0499
Onchocerca volvulus 0.007 0.0199 0.2105
Echinococcus multilocularis glycerol 3 phosphate dehydrogenase 0.0174 0.0703 0.1018
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.0032 0.5
Mycobacterium tuberculosis Probable oxidoreductase 0.0127 0.0475 0.0413
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.007 0.0199 0.0199
Echinococcus granulosus dro:myosuppressin receptor 0.007 0.0199 0.0288
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0125 0.0466 0.6459
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.007 0.0199 0.0288
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.007 0.0199 0.0288
Loa Loa (eye worm) hypothetical protein 0.006 0.0147 0.0147
Brugia malayi neuropeptide F receptor 0.007 0.0199 0.2228
Brugia malayi RNA binding protein 0.0135 0.0513 0.6034
Brugia malayi putative neuropeptide receptor NPR1 0.007 0.0199 0.2228
Onchocerca volvulus 0.007 0.0199 0.2105
Echinococcus granulosus sterol O acyltransferase 1 0.0227 0.096 0.139
Onchocerca volvulus 0.0036 0.0032 0.0198
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0137 0.0523 0.7015
Onchocerca volvulus 0.007 0.0199 0.2105
Echinococcus granulosus neuropeptides capa receptor 0.007 0.0199 0.0288
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.0032 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.007 0.0199 0.0184
Echinococcus granulosus g protein coupled receptor 0.007 0.0199 0.0288
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.007 0.0199 0.0288
Trypanosoma cruzi glycerol-3-phosphate dehydrogenase (FAD-dependent), putative 0.0174 0.0703 1
Echinococcus multilocularis lamin dm0 0.0061 0.0153 0.0221
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0202 0.0841 0.0841
Echinococcus multilocularis G protein coupled receptor 139 0.1211 0.5735 0.8306
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.007 0.0199 0.0288
Schistosoma mansoni tar DNA-binding protein 0.0135 0.0513 0.0499
Plasmodium falciparum ataxin-2 like protein, putative 0.0106 0.0372 0.5057
Schistosoma mansoni cellular tumor antigen P53 0.0212 0.0889 0.0875
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.007 0.0199 0.0184
Trypanosoma cruzi glycerol-3-phosphate dehydrogenase (FAD-dependent), putative 0.0174 0.0703 1
Onchocerca volvulus 0.007 0.0199 0.2105
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0015 0.0022
Trypanosoma brucei L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative 0.0174 0.0703 1
Echinococcus granulosus tm gpcr rhodopsin 0.007 0.0199 0.0288
Schistosoma mansoni opsin-like receptor 0.007 0.0199 0.0184
Echinococcus multilocularis dro:myosuppressin receptor 0.007 0.0199 0.0288
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0137 0.0523 0.7015
Loa Loa (eye worm) hypothetical protein 0.0032 0.0015 0.0015
Echinococcus granulosus tar DNA binding protein 0.0135 0.0513 0.0743
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0032 0.0015 0.0015
Brugia malayi RNA recognition motif domain containing protein 0.0135 0.0513 0.6034
Brugia malayi latrophilin 2 splice variant baaae 0.0138 0.053 0.6233
Schistosoma mansoni intermediate filament proteins 0.0061 0.0153 0.0138
Echinococcus multilocularis neuropeptide s receptor 0.007 0.0199 0.0288
Schistosoma mansoni hypothetical protein 0.0166 0.0664 0.0649
Echinococcus multilocularis rhodopsin orphan GPCR 0.007 0.0199 0.0288
Trypanosoma cruzi FAD dependent oxidoreductase, putative 0.0174 0.0703 1
Plasmodium vivax FAD-dependent glycerol-3-phosphate dehydrogenase, putative 0.0174 0.0703 1
Echinococcus multilocularis g protein coupled receptor 0.007 0.0199 0.0288
Brugia malayi G-protein coupled receptor 0.007 0.0199 0.2228
Echinococcus granulosus biogenic amine 5HT receptor 0.007 0.0199 0.0288
Loa Loa (eye worm) hypothetical protein 0.007 0.0199 0.0199
Trypanosoma cruzi PAB1-binding protein , putative 0.0106 0.0372 0.5057
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0036 0.0032 0.0047
Loa Loa (eye worm) hypothetical protein 0.0032 0.0015 0.0015
Brugia malayi GnHR receptor homolog 0.007 0.0199 0.2228
Loa Loa (eye worm) hypothetical protein 0.0032 0.0015 0.0015
Schistosoma mansoni tar DNA-binding protein 0.0135 0.0513 0.0499
Plasmodium falciparum glutathione reductase 0.005 0.0101 0.1022
Loa Loa (eye worm) hypothetical protein 0.007 0.0199 0.0199
Onchocerca volvulus Dimethylglycine dehydrogenase, mitochondrial homolog 0.0174 0.0703 0.7871
Plasmodium falciparum FAD-dependent glycerol-3-phosphate dehydrogenase, putative 0.0174 0.0703 1
Brugia malayi Serotonin receptor 0.007 0.0199 0.2228
Echinococcus granulosus cathepsin l1 0.0036 0.0032 0.0047
Echinococcus multilocularis ecdysone induced protein 78C 0.0032 0.0015 0.0022
Loa Loa (eye worm) hypothetical protein 0.007 0.0199 0.0199
Loa Loa (eye worm) hypothetical protein 0.0202 0.0841 0.0841
Loa Loa (eye worm) hypothetical protein 0.007 0.0199 0.0199
Echinococcus multilocularis neuropeptide receptor 0.1211 0.5735 0.8306
Loa Loa (eye worm) G-protein coupled receptor 0.007 0.0199 0.0199
Loa Loa (eye worm) hypothetical protein 0.007 0.0199 0.0199
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0032 0.0015 0.0022
Loa Loa (eye worm) hypothetical protein 0.0174 0.0703 0.0703
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0032 0.5
Toxoplasma gondii LsmAD domain-containing protein 0.0106 0.0372 0.5057
Plasmodium vivax ataxin-2 like protein, putative 0.0106 0.0372 0.5057
Echinococcus granulosus neuropeptide Y receptor 0.007 0.0199 0.0288
Brugia malayi hypothetical protein 0.007 0.0199 0.2228
Schistosoma mansoni opsin-like receptor 0.007 0.0199 0.0184
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0032 0.0015 0.0022
Echinococcus multilocularis neuropeptide FF receptor 2 0.007 0.0199 0.0288
Echinococcus granulosus neuropeptide s receptor 0.007 0.0199 0.0288
Echinococcus granulosus 7tm_1 domain containing protein 0.007 0.0199 0.0288
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0127 0.0475 0.0065
Onchocerca volvulus Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial homolog 0.0174 0.0703 0.7871
Schistosoma mansoni biogenic amine (dopamine) receptor 0.007 0.0199 0.0184
Loa Loa (eye worm) hypothetical protein 0.0032 0.0015 0.0015
Schistosoma mansoni hypothetical protein 0.0047 0.0088 0.0073
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.007 0.0199 0.0288
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0032 0.5
Loa Loa (eye worm) hypothetical protein 0.007 0.0199 0.0199
Mycobacterium tuberculosis Possible thiamine biosynthesis oxidoreductase ThiO 0.0174 0.0703 0.0665
Trypanosoma cruzi PAB1-binding protein , putative 0.0106 0.0372 0.5057
Loa Loa (eye worm) hypothetical protein 0.007 0.0199 0.0199
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.007 0.0199 0.0288
Loa Loa (eye worm) hypothetical protein 0.007 0.0199 0.0199
Echinococcus multilocularis GPCR, family 2 0.0064 0.0169 0.0244
Loa Loa (eye worm) glycerol-3-phosphate dehydrogenase 0.0174 0.0703 0.0703
Schistosoma mansoni neuropeptide F-like receptor 0.007 0.0199 0.0184
Trypanosoma brucei electron transfer flavoprotein-ubiquinone oxidoreductase, putative 0.0174 0.0703 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.007 0.0199 0.0288
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.0032 0.5
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.007 0.0199 0.0288
Echinococcus multilocularis g-protein coupled receptor 0.007 0.0199 0.0288
Echinococcus multilocularis rhodopsin orphan GPCR 0.007 0.0199 0.0288
Onchocerca volvulus Cathepsin F homolog 0.0036 0.0032 0.0198
Loa Loa (eye worm) hypothetical protein 0.007 0.0199 0.0199
Schistosoma mansoni rhodopsin-like orphan GPCR 0.007 0.0199 0.0184
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0032 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0036 0.0032 0.5
Echinococcus multilocularis serotonin receptor 0.007 0.0199 0.0288
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0033 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.007 0.0199 0.0199
Loa Loa (eye worm) hypothetical protein 0.0227 0.096 0.096
Brugia malayi follicle stimulating hormone receptor 0.007 0.0199 0.2228
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0032 0.5
Loa Loa (eye worm) hypothetical protein 0.0032 0.0015 0.0015
Echinococcus granulosus tm gpcr rhodopsin 0.007 0.0199 0.0288
Onchocerca volvulus 0.0036 0.0032 0.0198
Schistosoma mansoni amine GPCR 0.007 0.0199 0.0184
Schistosoma mansoni rhodopsin-like orphan GPCR 0.007 0.0199 0.0184
Loa Loa (eye worm) hypothetical protein 0.007 0.0199 0.0199
Schistosoma mansoni histamine h1 receptor 0.007 0.0199 0.0184
Loa Loa (eye worm) G-protein coupled receptor 0.007 0.0199 0.0199
Brugia malayi Intermediate filament tail domain containing protein 0.0061 0.0153 0.1664
Plasmodium falciparum ataxin-2 like protein, putative 0.0106 0.0372 0.5057
Echinococcus multilocularis fmrfamide receptor 0.007 0.0199 0.0288
Toxoplasma gondii FAD-dependent glycerol-3-phosphate dehydrogenase 0.0174 0.0703 1
Onchocerca volvulus 0.007 0.0199 0.2105
Echinococcus multilocularis rhodopsin orphan GPCR 0.007 0.0199 0.0288
Brugia malayi neuropeptide F receptor 0.007 0.0199 0.2228
Schistosoma mansoni hypothetical protein 0.0138 0.053 0.0515
Brugia malayi hypothetical protein 0.0068 0.019 0.2112
Echinococcus granulosus GPCR family 2 0.0064 0.0169 0.0244
Echinococcus granulosus g protein coupled receptor 0.007 0.0199 0.0288
Trypanosoma cruzi L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative 0.0174 0.0703 1
Onchocerca volvulus Cathepsin L homolog 0.0036 0.0032 0.0198
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0064 0.0169 0.0244
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0179 0.0726 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.007 0.0199 0.0288
Echinococcus granulosus hypothetical protein 0.007 0.0199 0.0288
Loa Loa (eye worm) hypothetical protein 0.0061 0.0153 0.0153
Mycobacterium ulcerans D-amino acid oxidase Aao 0.2089 1 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0032 0.0015 0.0022
Loa Loa (eye worm) hypothetical protein 0.007 0.0199 0.0199
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0179 0.0726 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.007 0.0199 0.0184
Onchocerca volvulus 0.007 0.0199 0.2105
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0032 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0032 0.5
Echinococcus granulosus neuropeptide Y receptor 0.007 0.0199 0.0288
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.007 0.0199 0.0199
Leishmania major hypothetical protein, conserved 0.0174 0.0703 1
Schistosoma mansoni ATP:guanidino kinase (Smc74) 0.0174 0.0703 0.0689
Schistosoma mansoni tar DNA-binding protein 0.0135 0.0513 0.0499
Echinococcus granulosus neuropeptide FF receptor 2 0.007 0.0199 0.0288
Echinococcus multilocularis thioredoxin glutathione reductase 0.005 0.0101 0.0146
Onchocerca volvulus 0.0036 0.0032 0.0198
Schistosoma mansoni rhodopsin-like orphan GPCR 0.007 0.0199 0.0184
Echinococcus granulosus thioredoxin glutathione reductase 0.005 0.0101 0.0146
Schistosoma mansoni thyroid hormone receptor 0.0436 0.1976 0.1964
Trypanosoma brucei PAB1-binding protein , putative 0.0106 0.0372 0.4495
Echinococcus multilocularis rhodopsin orphan GPCR 0.007 0.0199 0.0288
Loa Loa (eye worm) hypothetical protein 0.007 0.0199 0.0199
Onchocerca volvulus 0.0036 0.0032 0.0198
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0404 0.1818 0.2633
Schistosoma mansoni rhodopsin-like orphan GPCR 0.007 0.0199 0.0184
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.0032 0.5
Echinococcus granulosus cathepsin L cysteine proteinase 0.0036 0.0032 0.0047
Loa Loa (eye worm) hypothetical protein 0.007 0.0199 0.0199
Echinococcus granulosus g protein coupled receptor 0.007 0.0199 0.0288
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0015 0.0022
Loa Loa (eye worm) hypothetical protein 0.007 0.0199 0.0199
Echinococcus multilocularis FAD dependent oxidoreductase domain containing protein 0.0174 0.0703 0.1018
Onchocerca volvulus 0.007 0.0199 0.2105
Echinococcus multilocularis cathepsin L cysteine protease 0.0036 0.0032 0.0047
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.0032 0.5
Onchocerca volvulus 0.007 0.0199 0.2105
Leishmania major hypothetical protein, conserved 0.0106 0.0372 0.5057
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.0032 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0032 0.5
Brugia malayi Calcitonin receptor-like protein seb-1 0.0202 0.0841 1
Mycobacterium leprae Possible thiamine biosynthesis oxidoreductase ThiO 0.0174 0.0703 0.0303
Brugia malayi Serotonin/octopamine receptor family protein 7 0.007 0.0199 0.2228
Echinococcus multilocularis neuropeptide Y receptor 0.007 0.0199 0.0288
Trypanosoma brucei glycerol-3-phosphate dehydrogenase (FAD-dependent), mitochondrial 0.0174 0.0703 1
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.007 0.0199 0.0288
Loa Loa (eye worm) hypothetical protein 0.007 0.0199 0.0199
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0032 0.0015 0.0022
Echinococcus multilocularis serotonin receptor 0.007 0.0199 0.0288
Loa Loa (eye worm) hypothetical protein 0.0138 0.053 0.053
Onchocerca volvulus 0.0212 0.0889 1
Schistosoma mansoni hypothetical protein 0.007 0.0199 0.0184
Schistosoma mansoni biogenic amine (dopamine) receptor 0.007 0.0199 0.0184
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.007 0.0199 0.0288
Brugia malayi Tachykinin-like peptides receptor 99D 0.007 0.0199 0.2228
Loa Loa (eye worm) hypothetical protein 0.007 0.0199 0.0199
Loa Loa (eye worm) hypothetical protein 0.007 0.0199 0.0199
Echinococcus multilocularis neuropeptides capa receptor 0.007 0.0199 0.0288
Trypanosoma cruzi cysteine peptidase, putative 0.0137 0.0523 0.732
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.0032 0.5
Schistosoma mansoni adenoreceptor 0.007 0.0199 0.0184
Onchocerca volvulus 0.007 0.0199 0.2105
Schistosoma mansoni thyroid hormone receptor 0.0436 0.1976 0.1964
Brugia malayi pyruvate dehydrogenase phosphatase regulatory subunit precursor 0.0174 0.0703 0.8334
Schistosoma mansoni growth hormone secretagogue receptor 0.007 0.0199 0.0184
Brugia malayi dimethylglycine dehydrogenase, mitochondrial precursor, putative 0.0174 0.0703 0.8334
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0137 0.0523 0.7015
Echinococcus granulosus G protein coupled receptor 139 0.007 0.0199 0.0288
Brugia malayi intermediate filament protein 0.0061 0.0153 0.1664
Echinococcus multilocularis tachykinin peptides receptor 99D 0.007 0.0199 0.0288
Schistosoma mansoni sterol O-acyltransferase 1 0.0227 0.096 0.0946
Brugia malayi hypothetical protein 0.007 0.0199 0.2228
Echinococcus multilocularis neuropeptides capa receptor 0.007 0.0199 0.0288
Brugia malayi hypothetical protein 0.007 0.0199 0.2228
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.007 0.0199 0.0184
Schistosoma mansoni rhodopsin-like orphan GPCR 0.007 0.0199 0.0184
Schistosoma mansoni glycerol-3-phosphate dehydrogenase 0.0174 0.0703 0.0689
Schistosoma mansoni hypothetical protein 0.007 0.0199 0.0184
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.007 0.0199 0.0288
Schistosoma mansoni hypothetical protein 0.0064 0.0169 0.0154
Loa Loa (eye worm) cysteine protease 0.0036 0.0032 0.0032
Echinococcus granulosus serotonin receptor 0.007 0.0199 0.0288
Trypanosoma cruzi glycerol-3-phosphate dehydrogenase, putative 0.0174 0.0703 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.007 0.0199 0.2228
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0036 0.0032 0.0047
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0032 0.0015 0.0015
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0404 0.1818 0.2633
Echinococcus granulosus g-protein coupled receptor 0.007 0.0199 0.0288
Brugia malayi hypothetical protein 0.007 0.0199 0.2228
Loa Loa (eye worm) hypothetical protein 0.007 0.0199 0.0199
Echinococcus granulosus FTZ F1 alpha 0.0032 0.0015 0.0022
Loa Loa (eye worm) neuropeptide F receptor 0.007 0.0199 0.0199
Loa Loa (eye worm) hypothetical protein 0.007 0.0199 0.0199
Loa Loa (eye worm) hypothetical protein 0.007 0.0199 0.0199
Trypanosoma cruzi trypanothione reductase, putative 0.005 0.0101 0.1022
Schistosoma mansoni biogenic amine (dopamine) receptor 0.007 0.0199 0.0184
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0137 0.0523 0.7015
Loa Loa (eye worm) TAR-binding protein 0.0135 0.0513 0.0513
Brugia malayi RE15519p 0.007 0.0199 0.2228
Schistosoma mansoni fad oxidoreductase 0.0174 0.0703 0.0689
Schistosoma mansoni biogenic amine receptor 0.007 0.0199 0.0184
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0032 0.5
Brugia malayi Cathepsin L-like precursor 0.0036 0.0032 0.021
Schistosoma mansoni hypothetical protein 0.007 0.0199 0.0184
Leishmania major cathepsin L-like protease 0.0137 0.0523 0.732
Leishmania major glycerol-3-phosphate dehydrogenase-like protein 0.0174 0.0703 1
Brugia malayi G protein-coupled receptor 0.007 0.0199 0.2228
Schistosoma mansoni hypothetical protein 0.0064 0.0169 0.0154
Loa Loa (eye worm) hypothetical protein 0.007 0.0199 0.0199
Echinococcus multilocularis FTZ F1 alpha 0.0032 0.0015 0.0022
Brugia malayi larval opioid receptor 0.007 0.0199 0.2228
Onchocerca volvulus 0.007 0.0199 0.2105
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0064 0.0169 0.0244
Onchocerca volvulus 0.0061 0.0153 0.1572
Loa Loa (eye worm) hypothetical protein 0.007 0.0199 0.0199
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.007 0.0199 0.0288
Schistosoma mansoni NAD dehydrogenase 0.0174 0.0703 0.0689
Onchocerca volvulus 0.007 0.0199 0.2105
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.007 0.0199 0.0184
Echinococcus multilocularis rhodopsin orphan GPCR 0.007 0.0199 0.0288
Echinococcus granulosus tm gpcr rhodopsin 0.007 0.0199 0.0288
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0137 0.0523 0.7015
Loa Loa (eye worm) follicle stimulating hormone receptor 0.007 0.0199 0.0199
Loa Loa (eye worm) latrophilin receptor protein 2 0.0064 0.0169 0.0169
Loa Loa (eye worm) hypothetical protein 0.0205 0.0852 0.0852
Trypanosoma cruzi cysteine peptidase, putative 0.0137 0.0523 0.732
Brugia malayi cDNA sequence BC016226 0.0174 0.0703 0.8334
Echinococcus multilocularis lamin 0.0061 0.0153 0.0221
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0137 0.0523 0.7015
Echinococcus granulosus geminin 0.0166 0.0664 0.0961
Loa Loa (eye worm) hypothetical protein 0.007 0.0199 0.0199
Schistosoma mansoni neuropeptide receptor 0.007 0.0199 0.0184
Echinococcus multilocularis biogenic amine (5HT) receptor 0.007 0.0199 0.0288
Echinococcus granulosus rhodopsin orphan GPCR 0.007 0.0199 0.0288
Brugia malayi sulfakinin receptor protein 0.007 0.0199 0.2228
Echinococcus granulosus thyrotropin releasing hormone receptor 0.007 0.0199 0.0288
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0032 0.0015 0.0022
Echinococcus granulosus FAD dependent oxidoreductase domain containing protein 0.0174 0.0703 0.1018
Echinococcus granulosus biogenic amine 5HT receptor 0.007 0.0199 0.0288
Brugia malayi hypothetical protein 0.007 0.0199 0.2228
Brugia malayi cytoplasmic intermediate filament protein 0.0033 0.0016 0.0006
Brugia malayi putative neuropeptide receptor 0.007 0.0199 0.2228
Echinococcus granulosus tachykinin peptides receptor 99D 0.007 0.0199 0.0288
Schistosoma mansoni lamin 0.0061 0.0153 0.0138
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0015 0.0022
Schistosoma mansoni opsin-like receptor 0.007 0.0199 0.0184
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0202 0.0841 1
Loa Loa (eye worm) hypothetical protein 0.007 0.0199 0.0199
Loa Loa (eye worm) hypothetical protein 0.0212 0.0889 0.0889
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0032 0.5
Brugia malayi Dopamine receptor protein 1 0.007 0.0199 0.2228
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0032 0.5
Loa Loa (eye worm) neuropeptide F receptor 0.007 0.0199 0.0199
Brugia malayi Serotonin receptor 0.007 0.0199 0.2228
Echinococcus granulosus neuropeptide receptor 0.007 0.0199 0.0288
Echinococcus granulosus rhodopsin orphan GPCR 0.007 0.0199 0.0288
Echinococcus multilocularis thyroid hormone receptor alpha 0.0436 0.1976 0.2861
Onchocerca volvulus Cathepsin L homolog 0.0036 0.0032 0.0198
Brugia malayi G-protein coupled receptor 0.007 0.0199 0.2228
Trypanosoma cruzi cruzipain precursor, putative 0.0137 0.0523 0.732
Echinococcus granulosus tumor protein p63 0.1452 0.6905 1
Echinococcus multilocularis somatostatin receptor 0.007 0.0199 0.0288
Leishmania major cathepsin L-like protease 0.0137 0.0523 0.732
Mycobacterium tuberculosis Probable reductase 0.0114 0.0413 0.0344
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0032 0.0015 0.0022
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0047 0.0088 0.0128
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0114 0.0413 0.0344
Loa Loa (eye worm) glutathione reductase 0.005 0.0101 0.0101
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.007 0.0199 0.0288
Mycobacterium leprae PROBABLE D-AMINO ACID OXIDASE AAO 0.2089 1 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0135 0.0513 0.0513
Onchocerca volvulus Putative fad oxidoreductase 0.0174 0.0703 0.7871
Toxoplasma gondii thioredoxin reductase 0.005 0.0101 0.1022
Schistosoma mansoni peptide (allatostatin)-like receptor 0.007 0.0199 0.0184
Loa Loa (eye worm) hypothetical protein 0.0106 0.0372 0.0372
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0032 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0032 0.5
Echinococcus multilocularis sex peptide receptor 0.007 0.0199 0.0288
Loa Loa (eye worm) hypothetical protein 0.007 0.0199 0.0199
Loa Loa (eye worm) hypothetical protein 0.0174 0.0703 0.0703
Loa Loa (eye worm) hypothetical protein 0.007 0.0199 0.0199
Loa Loa (eye worm) hypothetical protein 0.007 0.0199 0.0199
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0032 0.0015 0.0022
Onchocerca volvulus 0.0061 0.0153 0.1572
Schistosoma mansoni hypothetical protein 0.007 0.0199 0.0184
Brugia malayi Cathepsin L-like precursor 0.0036 0.0032 0.021
Loa Loa (eye worm) TYRA-2 protein 0.007 0.0199 0.0199
Echinococcus granulosus ecdysone induced protein 78C 0.0032 0.0015 0.0022
Schistosoma mansoni rhodopsin-like orphan GPCR 0.007 0.0199 0.0184
Echinococcus granulosus fmrfamide receptor 0.007 0.0199 0.0288
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.007 0.0199 0.2105
Loa Loa (eye worm) hypothetical protein 0.007 0.0199 0.0199
Entamoeba histolytica anaerobic glycerol-3-phosphate dehydrogenase subunit A, putative 0.0174 0.0703 0.9677
Schistosoma mansoni neuropeptide receptor 0.1211 0.5735 0.5729
Brugia malayi Cathepsin L-like precursor 0.0036 0.0032 0.021
Schistosoma mansoni lamin 0.0061 0.0153 0.0138
Loa Loa (eye worm) hypothetical protein 0.007 0.0199 0.0199
Schistosoma mansoni amine GPCR 0.007 0.0199 0.0184
Echinococcus granulosus intermediate filament protein 0.0061 0.0153 0.0221
Onchocerca volvulus 0.0036 0.0032 0.0198
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0036 0.0032 0.5
Loa Loa (eye worm) hypothetical protein 0.007 0.0199 0.0199
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0114 0.0413 0.0344
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.007 0.0199 0.0184
Schistosoma mansoni d-amino acid oxidase 0.2089 1 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.007 0.0199 0.0184
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.007 0.0199 0.0184
Echinococcus granulosus rhodopsin orphan GPCR 0.007 0.0199 0.0288
Loa Loa (eye worm) hypothetical protein 0.007 0.0199 0.0199
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0032 0.0015 0.0015
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0032 0.0015 0.0022
Onchocerca volvulus 0.007 0.0199 0.2105
Loa Loa (eye worm) hypothetical protein 0.007 0.0199 0.0199
Echinococcus granulosus microtubule associated protein 2 0.1427 0.6786 0.9828
Echinococcus multilocularis musashi 0.0061 0.0153 0.0221
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0032 0.5
Schistosoma mansoni hypothetical protein 0.0064 0.0169 0.0154
Brugia malayi RE18450p 0.0174 0.0703 0.8334
Brugia malayi Thioredoxin reductase 0.005 0.0101 0.104
Schistosoma mansoni hypothetical protein 0.0404 0.1818 0.1806
Echinococcus multilocularis tar DNA binding protein 0.0135 0.0513 0.0743
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0036 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.007 0.0199 0.0199
Loa Loa (eye worm) hypothetical protein 0.007 0.0199 0.0199
Echinococcus multilocularis rhodopsin orphan GPCR 0.007 0.0199 0.0288
Mycobacterium tuberculosis Probable dehydrogenase 0.0114 0.0413 0.0344
Schistosoma mansoni fad oxidoreductase 0.0174 0.0703 0.0689
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0032 0.0015 0.0015
Echinococcus multilocularis rhodopsin orphan GPCR 0.007 0.0199 0.0288
Echinococcus granulosus allatostatin A receptor 0.007 0.0199 0.0288
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0032 0.0015 0.0015
Echinococcus multilocularis cathepsin L cysteine protease 0.0036 0.0032 0.0047
Schistosoma mansoni rhodopsin-like orphan GPCR 0.007 0.0199 0.0184
Plasmodium falciparum thioredoxin reductase 0.005 0.0101 0.1022
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 20 0.0174 0.0703 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0032 0.0032
Echinococcus granulosus neuropeptides capa receptor 0.007 0.0199 0.0288
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.007 0.0199 0.0184
Schistosoma mansoni neuropeptide f receptor 76f 0.007 0.0199 0.0184
Schistosoma mansoni cathepsin F (C01 family) 0.0036 0.0032 0.0017
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.007 0.0199 0.0199
Echinococcus granulosus cathepsin l cysteine peptidase 0.0036 0.0032 0.0047
Echinococcus multilocularis neuropeptide receptor 0.007 0.0199 0.0288
Schistosoma mansoni neuropeptide F-like receptor 0.007 0.0199 0.0184
Echinococcus multilocularis allatostatin A receptor 0.007 0.0199 0.0288
Loa Loa (eye worm) fibroinase 0.0036 0.0032 0.0032
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0036 0.0032 0.0032
Brugia malayi Dopamine receptor 0.007 0.0199 0.2228
Plasmodium vivax thioredoxin reductase, putative 0.005 0.0101 0.1022
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0127 0.0475 0.0413
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0036 0.0032 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0036 0.0032 0.5
Loa Loa (eye worm) hypothetical protein 0.0032 0.0015 0.0015
Echinococcus granulosus orexin receptor type 2 0.007 0.0199 0.0288
Schistosoma mansoni hypothetical protein 0.0064 0.0169 0.0154

Activities

Activity type Activity value Assay description Source Reference
Hydrolysis (functional) = 5 Compound was tested for rate of hydrolysis (percent hydrolyzed per 10 min) by cell extract from C. albicans H-317. ChEMBL. 1992114
ID50 (functional) = 20 ug ml-1 Compound was tested for its ability to inhibit chitin synthetase using C. albicans strain H-317. ChEMBL. 1992114
MIC (functional) = 333 ug ml-1 Compound was tested for its lowest concentration at which growth of H-317 strain of C. albicans was clearly inhibited. ChEMBL. 1992114
MIC (functional) = 333 ug ml-1 Compound was tested for its lowest concentration at which growth of 124 strain of C. albicans was clearly inhibited. ChEMBL. 1992114
MIC (functional) = 666 ug ml-1 Compound was tested for its lowest concentration at which growth of 124N5 strain of C. albicans was clearly inhibited. ChEMBL. 1992114
Transport inhibition (functional) = 0 % Compound was tested for percent inhibition of transport of (Leu)2 into C. albicans H-317. ChEMBL. 1992114
Transport inhibition (functional) = 27 % Compound was tested for percent inhibition of transport of (Met)2 into C. albicans H-317. ChEMBL. 1992114

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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