Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0329 | 0.143 | 0.5 |
Mycobacterium ulcerans | glutamine-binding lipoprotein GlnH | 0.0243 | 0 | 0.5 |
Chlamydia trachomatis | glutamine binding protein | 0.0243 | 0 | 0.5 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein (hisJ) | 0.0243 | 0 | 0.5 |
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.0243 | 0 | 0.5 |
Toxoplasma gondii | fructose-bisphospatase II | 0.0329 | 0.143 | 0.5 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0844 | 1 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0338 | 0.1579 | 0.0174 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein | 0.0243 | 0 | 0.5 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0649 | 0.6762 | 1 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0554 | 0.5183 | 0.4379 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0554 | 0.5183 | 0.4379 |
Trypanosoma brucei | fructose-1,6-bisphosphatase | 0.0329 | 0.143 | 0.5 |
Loa Loa (eye worm) | fructose-1,6-bisphosphatase | 0.0329 | 0.143 | 0.5 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0329 | 0.143 | 0.5 |
Echinococcus granulosus | glutamate receptor NMDA | 0.0506 | 0.4373 | 0.3435 |
Brugia malayi | fructose-1,6-bisphosphatase | 0.0329 | 0.143 | 0.5 |
Mycobacterium tuberculosis | Probable glutamine-binding lipoprotein GlnH (GLNBP) | 0.0243 | 0 | 0.5 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0506 | 0.4373 | 0.3435 |
Leishmania major | 0.0329 | 0.143 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (ADMET) | b 0 uM | Compound was tested for toxicity induced in human monocyte; b indicates Not detected | ChEMBL. | 12383019 |
IC50 (ADMET) | = 371.8 uM | Compound was tested for toxicity induced in murine macrophage | ChEMBL. | 12383019 |
IC50 (functional) | = 410.2 uM | In vitro cytotoxicity against C13 tumor cell line | ChEMBL. | 12383019 |
Potency ratio (ADMET) | = 0.6 | Potency ratio of the compound as the ratio of IC50 of DMXXA against murine macrophages to that of the IC50 of the compound against murine macrophages | ChEMBL. | 12383019 |
Potency ratio (ADMET) | = 0.6 | Potency ratio of the compound as the ratio of IC50 of DMXXA against murine macrophages to that of the IC50 of the compound against murine macrophages | ChEMBL. | 12383019 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.