Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Neprilysin | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | family M13 non-peptidase homologue (M13 family) | Neprilysin | 750 aa | 778 aa | 20.2 % |
Onchocerca volvulus | Neprilysin | 750 aa | 713 aa | 34.1 % | |
Onchocerca volvulus | Neprilysin | 750 aa | 682 aa | 31.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.0252 | 1 | 1 |
Mycobacterium leprae | probable zinc metalloprotease | 0.0114 | 0.294 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.1521 | 0.1521 |
Loa Loa (eye worm) | CMGC/MAPK/P38 protein kinase | 0.0252 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.142 | 0.142 |
Trypanosoma brucei | mitogen-activated protein kinase 3, putative | 0.0252 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.142 | 0.142 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.1521 | 0.1521 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.1521 | 0.1521 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.0252 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.1521 | 0.1521 |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.0252 | 1 | 1 |
Echinococcus granulosus | mitogen activated protein kinase 11 | 0.0252 | 1 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 3, putative | 0.0252 | 1 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.0252 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.294 | 0.294 |
Trypanosoma cruzi | mitogen-activated protein kinase 3, putative | 0.0252 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.294 | 0.294 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.142 | 0.142 |
Mycobacterium tuberculosis | Probable zinc metalloprotease Zmp1 | 0.0114 | 0.294 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.1521 | 0.1521 |
Echinococcus granulosus | mitogen activated protein kinase 14 | 0.0252 | 1 | 1 |
Onchocerca volvulus | 0.0056 | 0 | 0.5 | |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0114 | 0.294 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.294 | 0.294 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0084 | 0.142 | 0.142 |
Mycobacterium ulcerans | zinc metalloprotease | 0.0114 | 0.294 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.1521 | 0.1521 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.142 | 0.142 |
Leishmania major | mitogen-activated protein kinase 3, putative,map kinase 3, putative | 0.0252 | 1 | 0.5 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0084 | 0.142 | 0.142 |
Toxoplasma gondii | peptidase family M13 protein | 0.0114 | 0.294 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.