Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Serotonin 2a (5-HT2a) receptor | Starlite/ChEMBL | References |
Homo sapiens | dopamine receptor D4 | Starlite/ChEMBL | References |
Rattus norvegicus | Adrenergic receptor alpha-1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | g protein coupled receptor | Serotonin 2a (5-HT2a) receptor | 471 aa | 416 aa | 19.2 % |
Echinococcus multilocularis | g protein coupled receptor | Serotonin 2a (5-HT2a) receptor | 471 aa | 417 aa | 20.6 % |
Schistosoma japonicum | ko:K04209 neuropeptide Y receptor, invertebrate, putative | Serotonin 2a (5-HT2a) receptor | 471 aa | 405 aa | 25.4 % |
Echinococcus granulosus | g protein coupled receptor | Serotonin 2a (5-HT2a) receptor | 471 aa | 408 aa | 21.8 % |
Echinococcus multilocularis | g protein coupled receptor | Serotonin 2a (5-HT2a) receptor | 471 aa | 462 aa | 21.2 % |
Schistosoma japonicum | ko:K04136 adrenergic receptor, alpha 1b, putative | Serotonin 2a (5-HT2a) receptor | 471 aa | 422 aa | 27.5 % |
Onchocerca volvulus | Ubiquinol-cytochrome-c reductase complex assembly factor 1 homolog | Serotonin 2a (5-HT2a) receptor | 471 aa | 435 aa | 23.0 % |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | In vitro binding affinity at human Dopamine receptor D2L expressed in Sf9 cell membranes; ND means no data. | ChEMBL. | 12408724 | |
Ki (binding) | > 1000 nM | In vitro binding affinity at human cloned Dopamine receptor D4 expressed in Sf9 cell membranes | ChEMBL. | 12408724 |
Ki (binding) | > 1000 nM | In vitro binding affinity at 5-hydroxytryptamine 2A receptor in rat cortical membrane | ChEMBL. | 12408724 |
Ki (binding) | > 1000 nM | In vitro binding affinity at Alpha-1 adrenergic receptor in rat cortical tissues | ChEMBL. | 12408724 |
Ki (binding) | > 1000 nM | In vitro binding affinity at human cloned Dopamine receptor D4 expressed in Sf9 cell membranes | ChEMBL. | 12408724 |
Ki (binding) | > 1000 nM | In vitro binding affinity at 5-hydroxytryptamine 2A receptor in rat cortical membrane | ChEMBL. | 12408724 |
Ki (binding) | > 1000 nM | In vitro binding affinity at Alpha-1 adrenergic receptor in rat cortical tissues | ChEMBL. | 12408724 |
ND (binding) | 0 | In vitro binding affinity at human Dopamine receptor D2L expressed in Sf9 cell membranes; ND means no data. | ChEMBL. | 12408724 |
ND (binding) | 0 | Binding affinity ratio against human dopamine D2L versus D4, calculated using pKi (-logKi) values. | ChEMBL. | 12408724 |
ND (binding) | 0 | Binding affinity ratio against rat cortical tissue 5-HT2 versus human D2, calculated using pKi (-logKi) values;ND means no data. | ChEMBL. | 12408724 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.