Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0169 | 0.0093 | 0.0473 | |
Echinococcus multilocularis | Tolloid protein 1 | 0.1351 | 1 | 1 |
Brugia malayi | gamma-secretase subunit aph-1 | 0.0242 | 0.0702 | 0.3019 |
Brugia malayi | astacin protease protein 30 | 0.0169 | 0.0093 | 0.0398 |
Loa Loa (eye worm) | hypothetical protein | 0.0392 | 0.1957 | 0.1957 |
Brugia malayi | Matrixin family protein | 0.0212 | 0.0446 | 0.1919 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0318 | 0.134 | 0.0686 |
Loa Loa (eye worm) | DPY-31 protein | 0.0169 | 0.0093 | 0.0093 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.0093 | 0.0093 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.1351 | 1 | 1 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0318 | 0.134 | 0.0686 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0436 | 0.2325 | 0.5 |
Loa Loa (eye worm) | zinc metalloproteinase toh-2 | 0.0169 | 0.0093 | 0.0093 |
Brugia malayi | Low-density lipoprotein receptor repeat class B containing protein | 0.0392 | 0.1957 | 0.8416 |
Loa Loa (eye worm) | AStacin protease | 0.0845 | 0.5754 | 0.5754 |
Brugia malayi | Nematode astacin protease protein 30 | 0.0169 | 0.0093 | 0.0398 |
Loa Loa (eye worm) | low-density lipoprotein receptor repeat class B containing protein | 0.0392 | 0.1957 | 0.1957 |
Loa Loa (eye worm) | matrixin family protein | 0.0194 | 0.0299 | 0.0299 |
Echinococcus multilocularis | fibrillin 1 | 0.0436 | 0.2325 | 0.1745 |
Brugia malayi | Fibulin-1 precursor | 0.0436 | 0.2325 | 1 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0436 | 0.2325 | 1 |
Echinococcus granulosus | laminin | 0.0436 | 0.2325 | 0.1745 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.1351 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1296 | 0.9539 | 0.9539 |
Loa Loa (eye worm) | hypothetical protein | 0.055 | 0.3285 | 0.3285 |
Brugia malayi | Nematode astacin protease protein 30 | 0.0169 | 0.0093 | 0.0398 |
Brugia malayi | zinc metalloproteinase toh-2 precursor | 0.0169 | 0.0093 | 0.0398 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0436 | 0.2325 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0436 | 0.2325 | 0.2325 |
Loa Loa (eye worm) | matrixin family protein | 0.0212 | 0.0446 | 0.0446 |
Brugia malayi | Zinc metalloproteinase toh-2 precursor | 0.0169 | 0.0093 | 0.0398 |
Loa Loa (eye worm) | hypothetical protein | 0.0392 | 0.1957 | 0.1957 |
Loa Loa (eye worm) | gamma-secretase subunit aph-1 | 0.0242 | 0.0702 | 0.0702 |
Echinococcus multilocularis | laminin | 0.0436 | 0.2325 | 0.1745 |
Schistosoma mansoni | egf-like domain protein | 0.0392 | 0.1957 | 0.1349 |
Loa Loa (eye worm) | multiple epidermal growth factor-like domains 6 | 0.0436 | 0.2325 | 0.2325 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0194 | 0.0299 | 0.1529 |
Onchocerca volvulus | Matrilysin homolog | 0.0194 | 0.0299 | 0.1529 |
Onchocerca volvulus | Arrow homolog | 0.0392 | 0.1957 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.001 uM | Antitumor activity against human splenic B-lymphoblastoid Wil-NS cells. | ChEMBL. | 12431049 |
IC50 (functional) | = 0.001 uM | Antitumor activity against human renal adenocarcinoma ACHN cells. | ChEMBL. | 12431049 |
IC50 (functional) | = 0.001 uM | Antitumor activity against human renal adenocarcinoma ACHN cells. | ChEMBL. | 12431049 |
IC50 (functional) | = 0.002 uM | Antitumor activity against human acute B-lymphoblastic CCRF-SB leukemia cells. | ChEMBL. | 12431049 |
IC50 (functional) | = 0.002 uM | Antitumor activity against human acute B-lymphoblastic CCRF-SB leukemia cells. | ChEMBL. | 12431049 |
IC50 (functional) | = 0.003 uM | Antitumor activity against human bladder carcinoma 5637 cells. | ChEMBL. | 12431049 |
IC50 (functional) | = 0.003 uM | Antitumor activity against human bladder carcinoma 5637 cells. | ChEMBL. | 12431049 |
IC50 (functional) | = 0.004 uM | Antitumor activity against human acute T-lymphoblastic MOLT-4 leukemia cells. | ChEMBL. | 12431049 |
IC50 (functional) | = 0.004 uM | Antitumor activity against human acute T-lymphoblastic MOLT-4 leukemia cells. | ChEMBL. | 12431049 |
IC50 (functional) | = 0.007 uM | Antitumor activity against human acute T-lymphoblastic CCRF-CEM leukemia cells. | ChEMBL. | 12431049 |
IC50 (functional) | = 0.007 uM | Antitumor activity against human acute T-lymphoblastic CCRF-CEM leukemia cells. | ChEMBL. | 12431049 |
IC50 (functional) | = 0.01 uM | Antitumor activity against CD4+ human acute T-lymphoblastic MT-4 leukemia cells. | ChEMBL. | 12431049 |
IC50 (functional) | = 0.01 uM | Antitumor activity against human breast adenocarcinoma MCF-7 cells. | ChEMBL. | 12431049 |
IC50 (functional) | = 0.01 uM | Antitumor activity against CD4+ human acute T-lymphoblastic MT-4 leukemia cells. | ChEMBL. | 12431049 |
IC50 (functional) | = 0.01 uM | Antitumor activity against human breast adenocarcinoma MCF-7 cells. | ChEMBL. | 12431049 |
IC50 (functional) | = 0.05 uM | Antitumor activity against human skin melanoma G361 cells. | ChEMBL. | 12431049 |
IC50 (functional) | = 0.05 uM | Antitumor activity against human skin melanoma G361 cells. | ChEMBL. | 12431049 |
IC50 (functional) | = 0.1 uM | Antitumor activity against CD4+ human acute T-lymphoblastic C8166 leukemia cells. | ChEMBL. | 12431049 |
IC50 (functional) | = 0.1 uM | Antitumor activity against CD4+ human acute T-lymphoblastic C8166 leukemia cells. | ChEMBL. | 12431049 |
IC50 (functional) | = 0.15 uM | Antitumor activity against human Burkitt lymphoma Raji cells. | ChEMBL. | 12431049 |
IC50 (functional) | = 0.15 uM | Antitumor activity against human Burkitt lymphoma Raji cells. | ChEMBL. | 12431049 |
IC50 (functional) | = 0.2 uM | Antitumor activity against human colon adenocarcinoma HT-29 cells. | ChEMBL. | 12431049 |
IC50 (functional) | = 0.2 uM | Antitumor activity against human colon adenocarcinoma HT-29 cells. | ChEMBL. | 12431049 |
IC50 (functional) | = 0.3 uM | Antitumor activity against HeLa cervical carcinoma cells. | ChEMBL. | 12431049 |
IC50 (functional) | = 0.3 uM | Antitumor activity against HeLa cervical carcinoma cells. | ChEMBL. | 12431049 |
IC50 (functional) | = 0.4 uM | Antitumor activity against Hep-2 larynx carcinoma cells. | ChEMBL. | 12431049 |
IC50 (functional) | = 0.4 uM | Antitumor activity against Hep-2 larynx carcinoma cells. | ChEMBL. | 12431049 |
IC50 (functional) | = 0.6 uM | Antitumor activity against human hepatocellular carcinoma HepG-2 cells. | ChEMBL. | 12431049 |
IC50 (functional) | = 0.6 uM | Antitumor activity against human hepatocellular carcinoma HepG-2 cells. | ChEMBL. | 12431049 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 12431049 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.