Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | protease, serine, 3 | Starlite/ChEMBL | References |
Homo sapiens | protease, serine, 2 (trypsin 2) | References | |
Homo sapiens | protease, serine, 1 (trypsin 1) | References | |
Homo sapiens | coagulation factor II (thrombin) | Starlite/ChEMBL | References |
Homo sapiens | coagulation factor X | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | cercarial elastase (S01 family) | protease, serine, 2 (trypsin 2) | 247 aa | 240 aa | 25.8 % |
Schistosoma mansoni | cercarial elastase (S01 family) | protease, serine, 3 | 261 aa | 234 aa | 25.2 % |
Brugia malayi | Trypsin family protein | protease, serine, 1 (trypsin 1) | 247 aa | 287 aa | 21.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.1364 | 0.0289 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0092 | 0.1364 | 0.5 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0092 | 0.1364 | 0.0289 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.025 | 0.6328 | 0.6304 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.1985 | 0.1041 |
Echinococcus multilocularis | Tolloid protein 1 | 0.025 | 0.6328 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0347 | 0.9379 | 1 |
Onchocerca volvulus | 0.0319 | 0.8495 | 0.893 | |
Schistosoma mansoni | egf-like domain protein | 0.0084 | 0.1126 | 0.1126 |
Onchocerca volvulus | 0.0347 | 0.9379 | 1 | |
Echinococcus granulosus | Tolloid protein 1 | 0.025 | 0.6328 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0347 | 0.9379 | 1 |
Brugia malayi | Trypsin family protein | 0.0347 | 0.9379 | 1 |
Loa Loa (eye worm) | AStacin protease | 0.0146 | 0.3077 | 0.2364 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0092 | 0.1364 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.024 | 0.603 | 0.5943 |
Loa Loa (eye worm) | multiple epidermal growth factor-like domains 6 | 0.0092 | 0.1364 | 0.0289 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.025 | 0.6328 | 0.6328 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0347 | 0.9379 | 0.9379 |
Brugia malayi | Fibulin-1 precursor | 0.0092 | 0.1364 | 0.0289 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 78 nM | Inhibition constant against human factor Xa | ChEMBL. | 12565961 |
Ki (binding) | > 5000 nM | Inhibition constant of the compound against human thrombin | ChEMBL. | 12565961 |
Ki (binding) | > 5000 nM | Inhibition constant of the compound against bovine trypsin | ChEMBL. | 12565961 |
Ki app (binding) | = 78 nM | Inhibition constant against human factor Xa | ChEMBL. | 12565961 |
Ki app (binding) | > 5000 nM | Inhibition constant of the compound against human thrombin | ChEMBL. | 12565961 |
Ki app (binding) | > 5000 nM | Inhibition constant of the compound against bovine trypsin | ChEMBL. | 12565961 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.