Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0525 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0525 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0525 | 1 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0008 | 0.0634 | 0.0531 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0033 | 0.4393 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0525 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0026 | 0.3292 | 0.6573 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0525 | 1 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.001 | 0.0939 | 0.0754 |
Trichomonas vaginalis | helicase, putative | 0.0008 | 0.0525 | 1 |
Echinococcus multilocularis | cpg binding protein | 0.0035 | 0.4678 | 1 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.0525 | 1 |
Echinococcus granulosus | cpg binding protein | 0.0035 | 0.4678 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0026 | 0.3292 | 0.6813 |
Echinococcus granulosus | lamin dm0 | 0.0026 | 0.3292 | 0.6573 |
Loa Loa (eye worm) | intermediate filament protein | 0.0026 | 0.3292 | 0.6813 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.1274 | 0.097 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0014 | 0.1482 | 0.157 |
Schistosoma mansoni | intermediate filament proteins | 0.0026 | 0.3292 | 0.3218 |
Schistosoma mansoni | cpg binding protein | 0.0035 | 0.4678 | 0.4619 |
Echinococcus multilocularis | lamin | 0.0026 | 0.3292 | 0.6573 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0525 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0035 | 0.4678 | 0.4619 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0014 | 0.1482 | 0.1618 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.0525 | 1 |
Onchocerca volvulus | 0.0033 | 0.4393 | 1 | |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.001 | 0.0939 | 0.0754 |
Schistosoma mansoni | lamin | 0.0026 | 0.3292 | 0.3218 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0525 | 1 |
Echinococcus granulosus | lamin | 0.0026 | 0.3292 | 0.6573 |
Echinococcus granulosus | intermediate filament protein | 0.0026 | 0.3292 | 0.6573 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0525 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0026 | 0.3292 | 0.6831 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.3221 | 0.6607 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.1203 | 0.0764 |
Brugia malayi | intermediate filament protein | 0.0026 | 0.3292 | 0.6831 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.3292 | 0.6813 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0525 | 1 |
Schistosoma mansoni | lamin | 0.0026 | 0.3292 | 0.3218 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0525 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.1203 | 0.0764 |
Schistosoma mansoni | cpg binding protein | 0.0033 | 0.4393 | 0.4331 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0063 | 0.8867 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0525 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0525 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0525 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0525 | 1 |
Brugia malayi | CXXC zinc finger family protein | 0.0033 | 0.4393 | 1 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0013 | 0.1274 | 0.1583 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0525 | 1 |
Echinococcus multilocularis | musashi | 0.0026 | 0.3292 | 0.6573 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0013 | 0.1274 | 0.1583 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (functional) | = 106 uM | Cytostatic concentration against MT-4 cell | ChEMBL. | 10602704 |
CC50 (functional) | > 250 uM | Cytostatic concentration against CEM cell | ChEMBL. | 10602704 |
EC50 (functional) | = 0.23 uM | Inhibition of HIV-1 induced cytopathicity against CEM cell | ChEMBL. | 10602704 |
EC50 (functional) | = 1 uM | Inhibition of HIV-1 induced cytopathicity against MT-4 cell | ChEMBL. | 10602704 |
EC50 (functional) | > 50 uM | Inhibition of HIV-2 induced cytopathicity against CEM cell | ChEMBL. | 10602704 |
EC50 (functional) | > 250 uM | Inhibition of HIV-2 induced cytopathicity against MT-4 cell | ChEMBL. | 10602704 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.