Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cyclin E2 | Starlite/ChEMBL | References |
Homo sapiens | cyclin D1 | Starlite/ChEMBL | References |
Homo sapiens | cyclin B3 | Starlite/ChEMBL | References |
Homo sapiens | cyclin B2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | cyclin | 0.0116 | 0.1412 | 0.5 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.022 | 0.432 | 0.4223 |
Schistosoma mansoni | cyclins | 0.0086 | 0.0576 | 0.0983 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0104 | 0.1085 | 0.0933 |
Leishmania major | CYC2-like cyclin, putative,cyclin 6, putative | 0.0116 | 0.1412 | 0.5 |
Trichomonas vaginalis | cyclins, putative | 0.0116 | 0.1412 | 1 |
Entamoeba histolytica | cyclin, putative | 0.0116 | 0.1412 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0104 | 0.1085 | 0.0933 |
Trichomonas vaginalis | cyclin A, putative | 0.0116 | 0.1412 | 1 |
Trypanosoma brucei | mitotic cyclin 6 | 0.0116 | 0.1412 | 0.5 |
Trichomonas vaginalis | cyclins, putative | 0.0116 | 0.1412 | 1 |
Trypanosoma cruzi | CYC2-like cyclin, putative | 0.0116 | 0.1412 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0.1412 | 0.1265 |
Trichomonas vaginalis | cyclins, putative | 0.0116 | 0.1412 | 1 |
Trypanosoma cruzi | cyclin, putative | 0.0116 | 0.1412 | 0.5 |
Trichomonas vaginalis | cyclin B, putative | 0.0116 | 0.1412 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0.1412 | 0.1265 |
Plasmodium falciparum | cyclin | 0.0086 | 0.0576 | 0.5 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0116 | 0.1412 | 0.1265 |
Trichomonas vaginalis | cyclin B, putative | 0.0116 | 0.1412 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0065 | 0 | 0.5 |
Trichomonas vaginalis | cyclins, putative | 0.0116 | 0.1412 | 1 |
Echinococcus multilocularis | cyclin B | 0.0116 | 0.1412 | 0.1123 |
Schistosoma mansoni | cyclin B3 | 0.022 | 0.432 | 1 |
Echinococcus multilocularis | G2:mitotic specific cyclin B3 | 0.022 | 0.432 | 0.503 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0353 | 0.8019 | 1 |
Echinococcus granulosus | G2:mitotic specific cyclin B3 | 0.022 | 0.432 | 0.503 |
Echinococcus granulosus | cyclin B | 0.0116 | 0.1412 | 0.1123 |
Loa Loa (eye worm) | hypothetical protein | 0.0424 | 1 | 1 |
Trichomonas vaginalis | cyclin B, putative | 0.0116 | 0.1412 | 1 |
Trichomonas vaginalis | cyclin B, putative | 0.0116 | 0.1412 | 1 |
Trypanosoma cruzi | cyclin 6, putative | 0.0116 | 0.1412 | 0.5 |
Loa Loa (eye worm) | cyclin domain-containing protein | 0.022 | 0.432 | 0.4223 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0353 | 0.8019 | 1 |
Onchocerca volvulus | 0.0116 | 0.1412 | 0.5 | |
Schistosoma mansoni | cyclin B | 0.0116 | 0.1412 | 0.2995 |
Trypanosoma cruzi | cyclin, putative | 0.0116 | 0.1412 | 0.5 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0116 | 0.1412 | 0.1265 |
Giardia lamblia | G2/mitotic-specific cyclin B | 0.0116 | 0.1412 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 24 nM | Inhibition of cyclic dependent kinase 2 (CDK2)/cyclin E | ChEMBL. | 11170642 |
IC50 (binding) | = 24 nM | Inhibition of cyclic dependent kinase 2 (CDK2)/cyclin E | ChEMBL. | 11170642 |
IC50 (binding) | = 70 nM | Inhibition of human cyclic dependent kinase 1 (CDK1)/cyclin B | ChEMBL. | 11170642 |
IC50 (binding) | = 70 nM | Inhibition of human cyclic dependent kinase 1 (CDK1)/cyclin B | ChEMBL. | 11170642 |
IC50 (binding) | = 780 nM | Inhibition of cyclic dependent kinase 4 (CDK4)/cyclin D1 | ChEMBL. | 11170642 |
IC50 (binding) | = 780 nM | Inhibition of cyclic dependent kinase 4 (CDK4)/cyclin D1 | ChEMBL. | 11170642 |
IC50 (functional) | = 0.6 uM | Inhibition of PC-3 human prostate tumor cell proliferation | ChEMBL. | 11170642 |
IC50 (functional) | = 0.6 uM | Inhibition of PC-3 human prostate tumor cell proliferation | ChEMBL. | 11170642 |
IC50 (functional) | = 1.3 uM | Inhibition of MCF-7 human breast tumor cell proliferation | ChEMBL. | 11170642 |
IC50 (functional) | = 1.3 uM | Inhibition of DU-145 human prostate tumor cell proliferation | ChEMBL. | 11170642 |
IC50 (functional) | = 1.3 uM | Inhibition of MCF-7 human breast tumor cell proliferation | ChEMBL. | 11170642 |
IC50 (functional) | = 1.3 uM | Inhibition of DU-145 human prostate tumor cell proliferation | ChEMBL. | 11170642 |
IC50 (functional) | = 1.4 uM | Inhibition of DMS-114 human lung tumor cell proliferation | ChEMBL. | 11170642 |
IC50 (functional) | = 1.4 uM | Inhibition of DMS-114 human lung tumor cell proliferation | ChEMBL. | 11170642 |
IC50 (functional) | = 1.6 uM | Inhibition of A549 human lung tumor cell proliferation | ChEMBL. | 11170642 |
IC50 (functional) | = 1.6 uM | Inhibition of A549 human lung tumor cell proliferation | ChEMBL. | 11170642 |
IC50 (functional) | = 1.7 uM | Inhibition of MDA-MB-231 human breast tumor cell proliferation | ChEMBL. | 11170642 |
IC50 (functional) | = 1.7 uM | Inhibition of MDA-MB-231 human breast tumor cell proliferation | ChEMBL. | 11170642 |
IC50 (functional) | = 2 uM | Inhibition of HT-29 human colon tumor cell proliferation | ChEMBL. | 11170642 |
IC50 (functional) | = 2 uM | Inhibition of HT-29 human colon tumor cell proliferation | ChEMBL. | 11170642 |
IC50 (functional) | = 3.3 uM | Inhibition of HCT-15 human colon tumor cell proliferation | ChEMBL. | 11170642 |
IC50 (functional) | = 3.3 uM | Inhibition of HCT-15 human colon tumor cell proliferation | ChEMBL. | 11170642 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 11170642 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.