Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0043 | 0.0301 | 0.0135 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0301 | 0.4052 | 1 |
Schistosoma mansoni | DNA topoisomerase type I | 0.0194 | 0.2504 | 0.2406 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0043 | 0.0301 | 0.0718 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0039 | 0.0256 | 0.0145 |
Brugia malayi | hypothetical protein | 0.0168 | 0.2123 | 0.748 |
Leishmania major | DNA topoisomerase type IB small subunit | 0.0049 | 0.0391 | 0.0933 |
Echinococcus multilocularis | ras gtpase | 0.0059 | 0.0541 | 0.0417 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0032 | 0.0151 | 0.0359 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.0541 | 0.1546 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0164 | 0.2061 | 1 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0039 | 0.0248 | 0.1204 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0044 | 0.0317 | 0.0176 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0043 | 0.0301 | 0.0718 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0301 | 0.4052 | 0.5 |
Echinococcus granulosus | dna polymerase kappa | 0.0043 | 0.0301 | 0.0191 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0032 | 0.0151 | 0.0359 |
Brugia malayi | bHLH-PAS transcription factor | 0.0037 | 0.0221 | 0.0345 |
Plasmodium falciparum | topoisomerase I | 0.0194 | 0.2504 | 1 |
Echinococcus multilocularis | dna polymerase kappa | 0.0043 | 0.0301 | 0.0175 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0039 | 0.0248 | 0.0502 |
Echinococcus multilocularis | transfer RNA-Lys | 0.0037 | 0.0221 | 0.0093 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0043 | 0.0301 | 0.0718 |
Mycobacterium tuberculosis | Probable reductase | 0.0089 | 0.0973 | 0.4719 |
Trypanosoma cruzi | DNA topoisomerase type IB small subunit, putative | 0.0049 | 0.0391 | 0.0363 |
Schistosoma mansoni | DNA topoisomerase type I | 0.0145 | 0.1795 | 0.1688 |
Schistosoma mansoni | single-minded | 0.005 | 0.041 | 0.0285 |
Trypanosoma brucei | DNA topoisomerase IB, large subunit | 0.0145 | 0.1795 | 0.4276 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0301 | 0.4052 | 1 |
Brugia malayi | DNA topoisomerase I | 0.0194 | 0.2504 | 0.8912 |
Brugia malayi | Ras-related protein R-Ras2 | 0.0059 | 0.0541 | 0.1546 |
Brugia malayi | Thioredoxin reductase | 0.0039 | 0.0248 | 0.0447 |
Schistosoma mansoni | DNA topoisomerase type I | 0.0145 | 0.1795 | 0.1688 |
Trichomonas vaginalis | set domain proteins, putative | 0.0244 | 0.3224 | 0.7792 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0151 | 0.0083 |
Echinococcus granulosus | single minded 2 | 0.0037 | 0.0221 | 0.011 |
Trichomonas vaginalis | GTP-binding protein rit, putative | 0.0059 | 0.0541 | 0.0638 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0147 | 0.1817 | 0.8675 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0043 | 0.0301 | 0.0437 |
Brugia malayi | Ras protein let-60 | 0.0059 | 0.0541 | 0.1546 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0089 | 0.0973 | 0.4719 |
Echinococcus multilocularis | DNA topoisomerase 1 | 0.0194 | 0.2504 | 0.2406 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0214 | 0.2794 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0214 | 0.2794 | 1 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0147 | 0.182 | 0.4334 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0044 | 0.0317 | 0.0176 |
Trichomonas vaginalis | rap1 and, putative | 0.0059 | 0.0541 | 0.0638 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.071 | 1 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0039 | 0.0248 | 0.0591 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0147 | 0.182 | 0.4334 |
Loa Loa (eye worm) | glutathione reductase | 0.0039 | 0.0248 | 0.0447 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0311 | 0.4198 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0043 | 0.0301 | 0.0437 |
Trichomonas vaginalis | ral, putative | 0.0059 | 0.0541 | 0.0638 |
Echinococcus granulosus | ras gtpase | 0.0059 | 0.0541 | 0.0433 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0089 | 0.0973 | 0.4719 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0043 | 0.0301 | 0.0135 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0147 | 0.1817 | 0.8817 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0031 | 0.0129 | 0.0017 |
Trichomonas vaginalis | rheb, putative | 0.0059 | 0.0541 | 0.0638 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0301 | 0.4052 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0043 | 0.0301 | 0.0718 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0089 | 0.0973 | 0.4719 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0301 | 0.4052 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0099 | 0.1117 | 0.1705 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0043 | 0.0301 | 0.0718 |
Plasmodium vivax | topoisomerase I, putative | 0.0194 | 0.2504 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0043 | 0.0301 | 0.0718 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0301 | 0.4052 | 1 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0089 | 0.0973 | 0.4719 |
Brugia malayi | PAS domain containing protein | 0.005 | 0.041 | 0.1054 |
Trypanosoma brucei | unspecified product | 0.0036 | 0.0202 | 0.0481 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0099 | 0.1117 | 0.5418 |
Mycobacterium ulcerans | hypothetical protein | 0.0164 | 0.2061 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0043 | 0.0301 | 0.0718 |
Leishmania major | trypanothione reductase | 0.0039 | 0.0248 | 0.0591 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0099 | 0.1117 | 0.5418 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0044 | 0.0317 | 0.0176 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0043 | 0.0301 | 0.0718 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.005 | 0.041 | 0.0285 |
Onchocerca volvulus | 0.0244 | 0.3224 | 1 | |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0147 | 0.182 | 0.3978 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0301 | 0.4052 | 1 |
Trypanosoma brucei | DNA polymerase beta thumb, putative | 0.0044 | 0.0317 | 0.0756 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0039 | 0.0256 | 0.0128 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0043 | 0.0301 | 0.0135 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0301 | 0.4052 | 1 |
Echinococcus granulosus | DNA topoisomerase 1 | 0.0194 | 0.2504 | 0.2419 |
Plasmodium vivax | glutathione reductase, putative | 0.0039 | 0.0248 | 0.0502 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0147 | 0.1817 | 1 |
Loa Loa (eye worm) | Ras protein let-60 | 0.0059 | 0.0541 | 0.1546 |
Brugia malayi | hypoxia-induced factor 1 | 0.0155 | 0.1934 | 0.6771 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0043 | 0.0301 | 0.0718 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0311 | 0.4198 | 1 |
Trypanosoma cruzi | DNA topoisomerase IB, large subunit, putative | 0.0145 | 0.1795 | 0.3917 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0043 | 0.0301 | 0.0718 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0311 | 0.4198 | 1 |
Toxoplasma gondii | DNA topoisomerase I, putative | 0.0194 | 0.2504 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0043 | 0.0301 | 0.0135 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0155 | 0.1934 | 0.6771 |
Leishmania major | DNA topoisomerase IB, large subunit | 0.0145 | 0.1795 | 0.4276 |
Trypanosoma brucei | DNA topoisomerase type IB small subunit | 0.0049 | 0.0391 | 0.0933 |
Brugia malayi | glutathione reductase | 0.0039 | 0.0248 | 0.0447 |
Trichomonas vaginalis | ras-dva small GTPase, putative | 0.0059 | 0.0541 | 0.0638 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0053 | 0.0456 | 0.0527 |
Loa Loa (eye worm) | hypothetical protein | 0.0168 | 0.2123 | 0.748 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0043 | 0.0301 | 0.0718 |
Toxoplasma gondii | hypothetical protein | 0.005 | 0.0411 | 0.1187 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0036 | 0.0202 | 0.0481 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0089 | 0.0973 | 0.4719 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0301 | 0.4052 | 1 |
Schistosoma mansoni | microtubule-associated protein tau | 0.071 | 1 | 1 |
Trichomonas vaginalis | dexras1, putative | 0.0059 | 0.0541 | 0.0638 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0311 | 0.4198 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0301 | 0.4052 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0039 | 0.0248 | 0.0447 |
Loa Loa (eye worm) | DNA topoisomerase I | 0.0194 | 0.2504 | 0.8912 |
Brugia malayi | polk-prov protein | 0.0032 | 0.0151 | 0.0083 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0099 | 0.1117 | 0.5418 |
Onchocerca volvulus | 0.0037 | 0.0221 | 0.0297 | |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0301 | 0.4052 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0301 | 0.4052 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0039 | 0.0248 | 0.0502 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Relative activity (functional) | = 40 | Antinidatory effect was measured in the rat, relative to that of prostaglandin F2alpha (ED50 = 1.3 (0.9-1.87)mg/kg) | ChEMBL. | 7381852 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.