Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | IMP (inosine 5'-monophosphate) dehydrogenase 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena | 0.005 | 0.2231 | 0.0954 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0027 | 0.0671 | 0.1007 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0.019 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | IMP dehydrogenase | 0.0095 | 0.5355 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0027 | 0.0671 | 0.0931 |
Brugia malayi | GMP reductase | 0.0039 | 0.1511 | 0.1511 |
Mycobacterium tuberculosis | Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase | 0.005 | 0.2231 | 0.3951 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0095 | 0.5355 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0027 | 0.0671 | 0.0931 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase | 0.0039 | 0.1511 | 0.1511 |
Mycobacterium ulcerans | inosine 5'-monophosphate dehydrogenase | 0.0095 | 0.5355 | 1 |
Onchocerca volvulus | Putative GMP reductase | 0.0039 | 0.1511 | 0.5 |
Echinococcus multilocularis | inosine 5' monophosphate dehydrogenase 2 | 0.0095 | 0.5355 | 0.5265 |
Trypanosoma cruzi | GMP reductase | 0.0095 | 0.5355 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.002 | 0.019 | 0.5 |
Trypanosoma brucei | GMP reductase | 0.0095 | 0.5355 | 1 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.002 | 0.019 | 0.5 |
Loa Loa (eye worm) | IMP dehydrogenase 1 | 0.0095 | 0.5355 | 0.5265 |
Plasmodium vivax | inosine-5'-monophosphate dehydrogenase, putative | 0.0089 | 0.4965 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.002 | 0.019 | 0.019 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0027 | 0.0671 | 0.0931 |
Mycobacterium tuberculosis | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase | 0.0095 | 0.5355 | 1 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.002 | 0.019 | 0.5 |
Trypanosoma brucei | inosine-5'-monophosphate dehydrogenase | 0.0095 | 0.5355 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0671 | 0.049 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0027 | 0.0671 | 0.0931 |
Brugia malayi | hypothetical protein | 0.0027 | 0.0671 | 0.0671 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0027 | 0.0671 | 0.1007 |
Mycobacterium ulcerans | inosine 5-monophosphate dehydrogenase | 0.0089 | 0.4965 | 0.9244 |
Echinococcus granulosus | inosine 5' monophosphate dehydrogenase 2 | 0.0095 | 0.5355 | 0.5265 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0027 | 0.0671 | 0.0931 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) | 0.0095 | 0.5355 | 1 |
Leishmania major | inosine-5-monophosphate dehydrogenase | 0.0095 | 0.5355 | 1 |
Echinococcus multilocularis | muscleblind protein | 0.0162 | 1 | 1 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase family protein | 0.0095 | 0.5355 | 0.5355 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0162 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0162 | 1 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0027 | 0.0671 | 0.1007 |
Loa Loa (eye worm) | GMP reductase | 0.0039 | 0.1511 | 0.1346 |
Schistosoma mansoni | inosine-5-monophosphate dehydrogenase | 0.0095 | 0.5355 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0162 | 1 | 1 |
Leishmania major | guanosine monophosphate reductase | 0.0095 | 0.5355 | 1 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0095 | 0.5355 | 1 |
Toxoplasma gondii | IMP dehydrogenas | 0.0095 | 0.5355 | 1 |
Echinococcus granulosus | muscleblind protein | 0.0162 | 1 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0.019 | 0.5 |
Trypanosoma cruzi | GMP reductase | 0.0095 | 0.5355 | 1 |
Mycobacterium ulcerans | inosine 5-monophosphate dehydrogenase | 0.0045 | 0.1902 | 0.3313 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase | 0.0039 | 0.1511 | 0.1511 |
Plasmodium falciparum | inosine-5'-monophosphate dehydrogenase | 0.0089 | 0.4965 | 1 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0095 | 0.5355 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.