Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | IMP (inosine 5'-monophosphate) dehydrogenase 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | inosine 5' monophosphate dehydrogenase 2 | 0.0095 | 0.3557 | 0.5679 |
Echinococcus multilocularis | geminin | 0.0148 | 0.6263 | 1 |
Echinococcus granulosus | geminin | 0.0148 | 0.6263 | 1 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0035 | 0.051 | 0.0814 |
Mycobacterium ulcerans | inosine 5'-monophosphate dehydrogenase | 0.0095 | 0.3557 | 1 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase | 0.0039 | 0.0718 | 0.2017 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0095 | 0.3557 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.093 | 0.2614 |
Echinococcus granulosus | jumonji domain containing protein | 0.0035 | 0.051 | 0.0814 |
Plasmodium vivax | inosine-5'-monophosphate dehydrogenase, putative | 0.0089 | 0.3268 | 1 |
Onchocerca volvulus | Putative GMP reductase | 0.0039 | 0.0718 | 0.4706 |
Schistosoma mansoni | inosine-5-monophosphate dehydrogenase | 0.0095 | 0.3557 | 0.3557 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0095 | 0.3557 | 1 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0031 | 0.0274 | 0.0437 |
Trypanosoma brucei | inosine-5'-monophosphate dehydrogenase | 0.0095 | 0.3557 | 1 |
Schistosoma mansoni | jumonji domain containing protein | 0.0066 | 0.2085 | 0.2085 |
Loa Loa (eye worm) | diacylglycerol acyltransferase | 0.0055 | 0.1525 | 0.4286 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0083 | 0.2961 | 0.4728 |
Trypanosoma cruzi | GMP reductase | 0.0095 | 0.3557 | 1 |
Wolbachia endosymbiont of Brugia malayi | IMP dehydrogenase | 0.0095 | 0.3557 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0148 | 0.6263 | 0.6263 |
Schistosoma mansoni | diacylglycerol O-acyltransferase 1 | 0.0055 | 0.1525 | 0.1525 |
Schistosoma mansoni | hypothetical protein | 0.0148 | 0.6263 | 0.6263 |
Trypanosoma cruzi | GMP reductase | 0.0095 | 0.3557 | 1 |
Loa Loa (eye worm) | IMP dehydrogenase 1 | 0.0095 | 0.3557 | 1 |
Mycobacterium ulcerans | inosine 5-monophosphate dehydrogenase | 0.0089 | 0.3268 | 0.8869 |
Mycobacterium tuberculosis | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase | 0.0095 | 0.3557 | 1 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0052 | 0.1386 | 0.3896 |
Brugia malayi | diacylglycerol acyltransferase family protein | 0.0055 | 0.1525 | 0.4286 |
Onchocerca volvulus | 0.0055 | 0.1525 | 1 | |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0083 | 0.2961 | 0.4728 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) | 0.0095 | 0.3557 | 1 |
Toxoplasma gondii | dgat2l1-prov protein | 0.0055 | 0.1525 | 0.4286 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase | 0.0039 | 0.0718 | 0.2017 |
Brugia malayi | jmjC domain containing protein | 0.0031 | 0.0274 | 0.077 |
Brugia malayi | jmjC domain containing protein | 0.0083 | 0.2961 | 0.8325 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase family protein | 0.0095 | 0.3557 | 1 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena | 0.005 | 0.1249 | 0.0954 |
Plasmodium falciparum | inosine-5'-monophosphate dehydrogenase | 0.0089 | 0.3268 | 1 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0031 | 0.0274 | 0.077 |
Echinococcus multilocularis | inosine 5' monophosphate dehydrogenase 2 | 0.0095 | 0.3557 | 0.5679 |
Leishmania major | guanosine monophosphate reductase | 0.0095 | 0.3557 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0031 | 0.0274 | 0.0274 |
Brugia malayi | GMP reductase | 0.0039 | 0.0718 | 0.2017 |
Giardia lamblia | PHD finger protein 15 | 0.0025 | 0 | 0.5 |
Loa Loa (eye worm) | GMP reductase | 0.0039 | 0.0718 | 0.2017 |
Leishmania major | inosine-5-monophosphate dehydrogenase | 0.0095 | 0.3557 | 1 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0031 | 0.0274 | 0.0437 |
Trypanosoma brucei | GMP reductase | 0.0095 | 0.3557 | 1 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.0095 | 0.3557 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0031 | 0.0274 | 0.0274 |
Toxoplasma gondii | IMP dehydrogenas | 0.0095 | 0.3557 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | < 0.005 uM | Inhibitory activity against inosine monophosphate dehydrogenase IMPDH II | ChEMBL. | 12565969 |
IC50 (binding) | < 0.005 uM | Inhibitory activity against inosine monophosphate dehydrogenase IMPDH II | ChEMBL. | 12565969 |
IC50 (functional) | = 0.6 uM | Inhibitory activity against proliferation of CEM cell line | ChEMBL. | 12565969 |
IC50 (functional) | = 0.6 uM | Inhibitory activity against proliferation of CEM cell line | ChEMBL. | 12565969 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 12565969 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.