Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | steroid hormone receptor | 0.0043 | 0.543 | 0.543 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0043 | 0.543 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0043 | 0.543 | 0.543 |
Brugia malayi | steroid hormone receptor | 0.0043 | 0.543 | 0.543 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0043 | 0.543 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.543 | 0.543 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0043 | 0.543 | 1 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.006 | 1 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0043 | 0.543 | 0.543 |
Brugia malayi | Cytochrome P450 family protein | 0.006 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0043 | 0.543 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0043 | 0.543 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0043 | 0.543 | 1 |
Loa Loa (eye worm) | CYP4Cod1 | 0.006 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0043 | 0.543 | 0.543 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.543 | 0.543 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0043 | 0.543 | 0.543 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0043 | 0.543 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0043 | 0.543 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0043 | 0.543 | 0.543 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0043 | 0.543 | 1 |
Leishmania major | cytochrome p450-like protein | 0.006 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.543 | 0.543 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0043 | 0.543 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0043 | 0.543 | 1 |
Brugia malayi | ecdysteroid receptor | 0.0043 | 0.543 | 0.543 |
Onchocerca volvulus | 0.0043 | 0.543 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.543 | 0.543 |
Schistosoma mansoni | nuclear hormone receptor | 0.0043 | 0.543 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0043 | 0.543 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0043 | 0.543 | 0.543 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0043 | 0.543 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.543 | 0.543 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0043 | 0.543 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0043 | 0.543 | 0.543 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0043 | 0.543 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0043 | 0.543 | 0.543 |
Schistosoma mansoni | thyroid hormone receptor | 0.0043 | 0.543 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0043 | 0.543 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.006 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.543 | 0.543 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0043 | 0.543 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0043 | 0.543 | 0.543 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0043 | 0.543 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0043 | 0.543 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.5373 | 0.5373 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0043 | 0.543 | 0.543 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.006 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.543 | 0.543 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0043 | 0.543 | 0.543 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0043 | 0.543 | 0.543 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0043 | 0.543 | 0.543 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0043 | 0.543 | 0.543 |
Trypanosoma cruzi | cytochrome P450, putative | 0.006 | 1 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0043 | 0.543 | 0.543 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0043 | 0.543 | 0.543 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0043 | 0.543 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0043 | 0.543 | 0.543 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0043 | 0.543 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0043 | 0.543 | 0.543 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0043 | 0.543 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0043 | 0.543 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0043 | 0.543 | 0.543 |
Echinococcus granulosus | FTZ F1 alpha | 0.0043 | 0.543 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0043 | 0.543 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0043 | 0.543 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0043 | 0.543 | 0.543 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.006 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0043 | 0.543 | 0.543 |
Trypanosoma brucei | cytochrome P450, putative | 0.006 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.543 | 0.543 |
Brugia malayi | nuclear receptor NHR-88 | 0.0043 | 0.543 | 0.543 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0043 | 0.543 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0043 | 0.543 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0043 | 0.543 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0043 | 0.543 | 0.543 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0043 | 0.543 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0043 | 0.543 | 0.543 |
Brugia malayi | nuclear hormone receptor | 0.0043 | 0.543 | 0.543 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0043 | 0.543 | 1 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0043 | 0.543 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ILS (functional) | = 31 % | Evaluated % increase in life span in vivo against P388 Murine leukemia cells in trial 2 at a dose of 100 mg/kg | ChEMBL. | 7381855 |
ILS (functional) | = 34 % | Evaluated % increase in life span in vivo against P388 Murine leukemia cells in trial 1 at a dose of 50 mg/kg | ChEMBL. | 7381855 |
ILS (functional) | = 35 % | Evaluated % increase in life span in vivo against P388 Murine leukemia cells in trial 2 at a dose of 200 mg/kg | ChEMBL. | 7381855 |
ILS (functional) | = 37 % | Evaluated % increase in life span in vivo against P388 Murine leukemia cells in trial 2 at a dose of 25 mg/kg | ChEMBL. | 7381855 |
ILS (functional) | = 40 % | Evaluated % increase in life span in vivo against P388 Murine leukemia cells in trial 1 at a dose of 100 mg/kg | ChEMBL. | 7381855 |
ILS (functional) | = 44 % | Evaluated % increase in life span in vivo against P388 Murine leukemia cells in trial 2 at a dose of 50 mg/kg | ChEMBL. | 7381855 |
ILS (functional) | = 45 % | Evaluated % increase in life span in vivo against P388 Murine leukemia cells in trial 2 at a dose of 12.5 mg/kg | ChEMBL. | 7381855 |
ILS (functional) | = 47 % | Evaluated % increase in life span in vivo against P388 Murine leukemia cells in trial 1 at a dose of 25 mg/kg | ChEMBL. | 7381855 |
ILS (functional) | = 47 % | Evaluated % increase in life span in vivo against P388 Murine leukemia cells in trial 1 at a dose of 12.5 mg/kg | ChEMBL. | 7381855 |
ILS (functional) | = 49 % | Evaluated % increase in life span in vivo against P388 Murine leukemia cells in trial 1 at a dose of 200 mg/kg | ChEMBL. | 7381855 |
ILS (functional) | = 58 % | Evaluated % increase in life span in vivo against P388 Murine leukemia cells in trial 2 at a dose of 400 mg/kg | ChEMBL. | 7381855 |
Inhibition (functional) | = 61 % | Evaluated for growth inhibition against cultured L1210 cells after 48 hour drug exposure in trial 2 at a dose of 1.45*10e-9 | ChEMBL. | 7381855 |
Inhibition (functional) | = 84 % | Evaluated for growth inhibition against cultured L1210 cells after 48 hour drug exposure in trial 1 at a dose of 1.45*10e-9 | ChEMBL. | 7381855 |
Inhibition (functional) | = 97 % | Evaluated for growth inhibition against cultured L1210 cells after 48 hour drug exposure in trial 2 at a dose of 1.45*10e-8 | ChEMBL. | 7381855 |
Inhibition (functional) | = 98 % | Evaluated for growth inhibition against cultured L1210 cells after 48 hour drug exposure in trial 1 at a dose of 1.45*10e-8 | ChEMBL. | 7381855 |
logP (ADMET) | = 0.95 | Partition coefficient determined using pi values | ChEMBL. | 7381855 |
logP (ADMET) | = 1.68 | Partition coefficient (logP) (HPLC) | ChEMBL. | 7381855 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.