Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ATPase, H+/K+ exchanging, alpha polypeptide | Starlite/ChEMBL | References |
Homo sapiens | ATPase, H+/K+ exchanging, beta polypeptide | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | vacuolar-type Ca2+-ATPase 2 | ATPase, H+/K+ exchanging, alpha polypeptide | 1035 aa | 861 aa | 26.8 % |
Echinococcus granulosus | sodium:potassium dependent atpase beta subunit | ATPase, H+/K+ exchanging, beta polypeptide | 291 aa | 264 aa | 28.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.1523 | 0.5114 | 0.5098 |
Echinococcus granulosus | nervana 2 | 0.0077 | 0.0179 | 0.0128 |
Brugia malayi | Na,K-ATPase alpha subunit | 0.004 | 0.0051 | 0.0019 |
Echinococcus multilocularis | nervana 2 | 0.0077 | 0.0179 | 0.0128 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.2955 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.1523 | 0.5114 | 0.5089 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1453 | 0.4874 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1453 | 0.4874 | 0.5 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.2955 | 1 | 1 |
Onchocerca volvulus | 0.0077 | 0.0179 | 1 | |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.1386 | 0.4647 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.0179 | 0.0179 |
Echinococcus multilocularis | sodium:potassium dependent atpase beta subunit | 0.0077 | 0.0179 | 0.0128 |
Echinococcus granulosus | carbonic anhydrase | 0.1523 | 0.5114 | 0.5089 |
Leishmania major | carbonic anhydrase-like protein | 0.2955 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.1523 | 0.5114 | 0.5089 |
Loa Loa (eye worm) | hypothetical protein | 0.1523 | 0.5114 | 0.5114 |
Echinococcus granulosus | carbonic anhydrase II | 0.2955 | 1 | 1 |
Schistosoma mansoni | sodium / potassium ATPase beta chain | 0.0077 | 0.0179 | 0.0128 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.2955 | 1 | 0.5 |
Schistosoma mansoni | sodium/potassium-dependent atpase beta subunit | 0.0077 | 0.0179 | 0.0128 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.2955 | 1 | 1 |
Loa Loa (eye worm) | sodium/potassium-transporting ATPase subunit alpha | 0.0034 | 0.0033 | 0.0033 |
Plasmodium falciparum | carbonic anhydrase | 0.1523 | 0.5114 | 0.5 |
Echinococcus granulosus | sodium:potassium dependent atpase beta subunit | 0.0077 | 0.0179 | 0.0128 |
Giardia lamblia | Potassium-transporting ATPase alpha chain 1 | 0.004 | 0.0051 | 0.5 |
Onchocerca volvulus | 0.0077 | 0.0179 | 1 | |
Toxoplasma gondii | hypothetical protein | 0.1523 | 0.5114 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.2955 | 1 | 0.5 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.1523 | 0.5114 | 0.5114 |
Echinococcus multilocularis | nervana 2 | 0.0077 | 0.0179 | 0.0128 |
Echinococcus multilocularis | nervana 2 | 0.0077 | 0.0179 | 0.0128 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.1523 | 0.5114 | 0.5098 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.2955 | 1 | 0.5 |
Echinococcus multilocularis | carbonic anhydrase | 0.1523 | 0.5114 | 0.5089 |
Mycobacterium ulcerans | carbonic anhydrase | 0.1386 | 0.4647 | 0.953 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0021 | 0.0021 |
Echinococcus multilocularis | carbonic anhydrase | 0.1523 | 0.5114 | 0.5089 |
Echinococcus multilocularis | nervana 2 | 0.0077 | 0.0179 | 0.0128 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.2955 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase | 0.1386 | 0.4647 | 0.4619 |
Echinococcus granulosus | sodium:potassium transporting ATPase subunit | 0.0077 | 0.0179 | 0.0128 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.1523 | 0.5114 | 0.5098 |
Schistosoma mansoni | carbonic anhydrase | 0.1523 | 0.5114 | 0.5089 |
Echinococcus multilocularis | carbonic anhydrase | 0.1523 | 0.5114 | 0.5089 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.0898 | 0.298 | 0.8602 |
Entamoeba histolytica | carbonic anhydrase, putative | 0.1386 | 0.4647 | 0.5 |
Echinococcus granulosus | nervana 2 | 0.0077 | 0.0179 | 0.0128 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.0179 | 0.0179 |
Schistosoma mansoni | sodium/potassium-dependent atpase beta subunit | 0.0077 | 0.0179 | 0.0128 |
Echinococcus multilocularis | sodium:potassium dependent atpase beta subunit | 0.0077 | 0.0179 | 0.0128 |
Loa Loa (eye worm) | hypothetical protein | 0.1523 | 0.5114 | 0.5114 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.2955 | 1 | 1 |
Echinococcus multilocularis | sodium:potassium transporting ATPase subunit | 0.0077 | 0.0179 | 0.0128 |
Schistosoma mansoni | carbonic anhydrase-related | 0.1523 | 0.5114 | 0.5089 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0051 | 0.0051 |
Schistosoma mansoni | sodium/potassium-dependent atpase beta subunit | 0.0077 | 0.0179 | 0.0128 |
Echinococcus granulosus | carbonic anhydrase | 0.1523 | 0.5114 | 0.5089 |
Echinococcus granulosus | nervana 2 | 0.0077 | 0.0179 | 0.0128 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase | 0.0964 | 0.3207 | 1 |
Echinococcus granulosus | sodium:potassium dependent atpase beta subunit | 0.0077 | 0.0179 | 0.0128 |
Echinococcus granulosus | sodium:potassium dependent atpase beta subunit | 0.0077 | 0.0179 | 0.0128 |
Echinococcus multilocularis | carbonic anhydrase II | 0.2955 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.211 | 0.7115 | 0.7115 |
Schistosoma mansoni | transmemberane protein | 0.0077 | 0.0179 | 0.0128 |
Mycobacterium ulcerans | carbonic anhydrase | 0.1453 | 0.4874 | 1 |
Loa Loa (eye worm) | Na,K-ATPase alpha subunit | 0.004 | 0.0051 | 0.0051 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.1523 | 0.5114 | 0.5098 |
Echinococcus granulosus | carbonic anhydrase | 0.1523 | 0.5114 | 0.5089 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.1523 | 0.5114 | 0.5098 |
Echinococcus multilocularis | sodium:potassium dependent atpase beta subunit | 0.0077 | 0.0179 | 0.0128 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0007 | 0.0007 |
Echinococcus granulosus | nervana 2 | 0.0077 | 0.0179 | 0.0128 |
Schistosoma mansoni | carbonic anhydrase-related | 0.1523 | 0.5114 | 0.5089 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 7 uM | Inhibitory activity against dog gastric proton-pump enzyme H+/K+ ATPase | ChEMBL. | 2153817 |
IC50 (binding) | = 7 uM | Inhibitory activity against dog gastric proton-pump enzyme H+/K+ ATPase | ChEMBL. | 2153817 |
Inhibition (binding) | = 91 % | Percent inhibition of gastric proton-pump enzyme H+/K+ ATPase was determined at 50 uM | ChEMBL. | 2153817 |
Inhibition (binding) | = 91 % | Percent inhibition of gastric proton-pump enzyme H+/K+ ATPase was determined at 50 uM | ChEMBL. | 2153817 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.