Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | cysteine peptidase, putative | 0.0066 | 0.5497 | 1 |
Loa Loa (eye worm) | ctsf protein | 0.0017 | 0.0579 | 0.1527 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0066 | 0.5497 | 0.5 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0017 | 0.0579 | 0.1527 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0017 | 0.0579 | 0.0579 |
Trichomonas vaginalis | amylase, putative | 0.011 | 1 | 1 |
Entamoeba histolytica | oligo-1,6-glucosidase, putative | 0.0012 | 0.005 | 0.005 |
Trichomonas vaginalis | amylase, putative | 0.011 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0017 | 0.0579 | 0.0579 |
Loa Loa (eye worm) | cysteine protease | 0.0017 | 0.0579 | 0.1527 |
Leishmania major | cathepsin L-like protease | 0.0066 | 0.5497 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0066 | 0.5497 | 0.5 |
Onchocerca volvulus | 0.0017 | 0.0579 | 1 | |
Trichomonas vaginalis | alpha-amylase, putative | 0.0098 | 0.8778 | 0.8778 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0017 | 0.0579 | 0.0579 |
Onchocerca volvulus | Cathepsin F homolog | 0.0017 | 0.0579 | 1 |
Mycobacterium tuberculosis | 1,4-alpha-glucan branching enzyme GlgB (glycogen branching enzyme) | 0.0049 | 0.3789 | 1 |
Plasmodium vivax | vivapain-2 | 0.0017 | 0.0579 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0017 | 0.0579 | 0.0579 |
Loa Loa (eye worm) | alpha amylase | 0.0012 | 0.005 | 0.0133 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0017 | 0.0579 | 0.0579 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0017 | 0.0579 | 0.0579 |
Toxoplasma gondii | glycosyltransferase | 0.0049 | 0.3789 | 1 |
Entamoeba histolytica | alpha-amylase family protein | 0.011 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0066 | 0.5497 | 0.5 |
Trypanosoma cruzi | major cysteine proteinase, putative | 0.0052 | 0.407 | 0.7098 |
Entamoeba histolytica | beta/alpha-amylase precursor, putative | 0.0012 | 0.005 | 0.005 |
Schistosoma mansoni | alpha-amylase | 0.0012 | 0.005 | 0.0133 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0017 | 0.0579 | 0.0579 |
Echinococcus granulosus | alpha glucosidase | 0.0012 | 0.005 | 0.0133 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0017 | 0.0579 | 0.0579 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0017 | 0.0579 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0017 | 0.0579 | 0.0579 |
Brugia malayi | Alpha amylase, catalytic domain containing protein | 0.0012 | 0.005 | 0.0133 |
Trichomonas vaginalis | alpha-amylase, putative | 0.011 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0066 | 0.5497 | 0.5 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0017 | 0.0579 | 0.1527 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0012 | 0.005 | 0.005 |
Trichomonas vaginalis | starch branching enzyme II, putative | 0.0049 | 0.3789 | 0.3789 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0066 | 0.5497 | 0.5 |
Toxoplasma gondii | cathepsin CPL | 0.0017 | 0.0579 | 0.1413 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0012 | 0.005 | 0.005 |
Brugia malayi | Cathepsin L-like precursor | 0.0017 | 0.0579 | 0.1527 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0017 | 0.0579 | 0.0579 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0017 | 0.0579 | 0.1527 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0066 | 0.5497 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0017 | 0.0579 | 0.1413 |
Onchocerca volvulus | 0.0017 | 0.0579 | 1 | |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0066 | 0.5497 | 1 |
Trichomonas vaginalis | amylase, putative | 0.0012 | 0.005 | 0.005 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0012 | 0.005 | 0.005 |
Brugia malayi | Cathepsin L-like precursor | 0.0017 | 0.0579 | 0.1527 |
Brugia malayi | Cathepsin L-like precursor | 0.0017 | 0.0579 | 0.1527 |
Loa Loa (eye worm) | alpha amylase | 0.0012 | 0.005 | 0.0133 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0017 | 0.0579 | 0.0579 |
Schistosoma mansoni | alpha-amylase | 0.0012 | 0.005 | 0.0133 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0066 | 0.5497 | 0.5 |
Entamoeba histolytica | 1,4-alpha-glucan branching enzyme, putative | 0.0049 | 0.3789 | 0.3789 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0017 | 0.0579 | 0.1527 |
Echinococcus granulosus | trehalose 6 phosphate hydrolase | 0.0012 | 0.005 | 0.0133 |
Loa Loa (eye worm) | fibroinase | 0.0017 | 0.0579 | 0.1527 |
Onchocerca volvulus | Cathepsin L homolog | 0.0017 | 0.0579 | 1 |
Trichomonas vaginalis | amylase, putative | 0.0049 | 0.3789 | 0.3789 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0017 | 0.0579 | 0.1413 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0012 | 0.005 | 0.005 |
Onchocerca volvulus | 0.0017 | 0.0579 | 1 | |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0017 | 0.0579 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0066 | 0.5497 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0017 | 0.0579 | 0.0579 |
Entamoeba histolytica | hypothetical protein | 0.0012 | 0.005 | 0.005 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0017 | 0.0579 | 0.0579 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.006 | 0.4918 | 0.8824 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0017 | 0.0579 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0012 | 0.005 | 0.005 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0017 | 0.0579 | 0.1527 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0017 | 0.0579 | 0.0579 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0017 | 0.0579 | 0.0579 |
Trichomonas vaginalis | alpha-amylase, putative | 0.011 | 1 | 1 |
Echinococcus multilocularis | glucan (1,4 alpha), branching enzyme 1 | 0.0049 | 0.3789 | 1 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0012 | 0.005 | 0.005 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0066 | 0.5497 | 0.5 |
Brugia malayi | 1,4-alpha-glucan branching enzyme | 0.0049 | 0.3789 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0017 | 0.0579 | 0.1527 |
Brugia malayi | Cathepsin L-like precursor | 0.0017 | 0.0579 | 0.1527 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0017 | 0.0579 | 0.0579 |
Schistosoma mansoni | starch branching enzyme II | 0.0049 | 0.3789 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0579 | 0.1527 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0017 | 0.0579 | 0.1527 |
Plasmodium vivax | vivapain-2 | 0.0017 | 0.0579 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0066 | 0.5497 | 0.5 |
Echinococcus multilocularis | cysteine protease | 0.0017 | 0.0579 | 0.1413 |
Onchocerca volvulus | 0.0017 | 0.0579 | 1 | |
Entamoeba histolytica | alpha-amylase family protein | 0.0012 | 0.005 | 0.005 |
Toxoplasma gondii | alpha amylase, catalytic domain-containing protein | 0.0049 | 0.3789 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0017 | 0.0579 | 0.0579 |
Mycobacterium ulcerans | glycogen branching protein | 0.0049 | 0.3789 | 1 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0017 | 0.0579 | 0.1527 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0017 | 0.0579 | 0.1413 |
Toxoplasma gondii | 1,4-alpha-glucan-branching enzyme | 0.0049 | 0.3789 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0017 | 0.0579 | 0.0579 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0066 | 0.5497 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0017 | 0.0579 | 0.0579 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0066 | 0.5497 | 1 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0012 | 0.005 | 0.005 |
Brugia malayi | Cathepsin L-like precursor | 0.0017 | 0.0579 | 0.1527 |
Onchocerca volvulus | 0.0017 | 0.0579 | 1 | |
Schistosoma mansoni | alpha-amylase | 0.0012 | 0.005 | 0.0133 |
Echinococcus granulosus | glucan 14 alpha branching enzyme 1 | 0.0049 | 0.3789 | 1 |
Chlamydia trachomatis | 1,4-alpha-glucan branching enzyme | 0.0049 | 0.3789 | 1 |
Schistosoma mansoni | alpha-amylase | 0.0012 | 0.005 | 0.0133 |
Leishmania major | cathepsin L-like protease | 0.0066 | 0.5497 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0017 | 0.0579 | 0.0579 |
Mycobacterium leprae | Putative uncharacterized protein ML2045 | 0.0012 | 0.005 | 0.5 |
Echinococcus granulosus | cathepsin l1 | 0.0017 | 0.0579 | 0.1527 |
Trichomonas vaginalis | alpha-amylase, putative | 0.011 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0066 | 0.5497 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0017 | 0.0579 | 0.0579 |
Entamoeba histolytica | alpha-amylase family protein | 0.0012 | 0.005 | 0.005 |
Brugia malayi | Alpha amylase, catalytic domain containing protein | 0.0012 | 0.005 | 0.0133 |
Entamoeba histolytica | 1,4-alpha-glucan branching enzyme, putative | 0.0049 | 0.3789 | 0.3789 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0017 | 0.0579 | 0.1413 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.3789 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0017 | 0.0579 | 0.0579 |
Schistosoma mansoni | alpha-amylase | 0.0012 | 0.005 | 0.0133 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0017 | 0.0579 | 0.0579 |
Schistosoma mansoni | hypothetical protein | 0.0012 | 0.005 | 0.0133 |
Onchocerca volvulus | Cathepsin L homolog | 0.0017 | 0.0579 | 1 |
Onchocerca volvulus | 0.0017 | 0.0579 | 1 | |
Entamoeba histolytica | cysteine protease, putative | 0.0017 | 0.0579 | 0.0579 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0012 | 0.005 | 0.005 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0017 | 0.0579 | 0.0579 |
Giardia lamblia | 1,4-alpha-glucan branching enzyme | 0.0049 | 0.3789 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0017 | 0.0579 | 0.0579 |
Onchocerca volvulus | 0.0017 | 0.0579 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0017 | 0.0579 | 0.0579 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0017 | 0.0579 | 0.0579 |
Entamoeba histolytica | alpha-amylase, putative | 0.0012 | 0.005 | 0.005 |
Echinococcus multilocularis | cysteine protease | 0.0017 | 0.0579 | 0.1413 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0012 | 0.005 | 0.005 |
Entamoeba histolytica | alpha-amylase, putative | 0.0012 | 0.005 | 0.005 |
Trichomonas vaginalis | alpha-amylase, putative | 0.011 | 1 | 1 |
Trichomonas vaginalis | alpha-amylase, putative | 0.0012 | 0.005 | 0.005 |
Leishmania major | cathepsin L-like protease | 0.0066 | 0.5497 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 1.5 uM | In vitro cytotoxicity of the compound against mouse TLX5 lymphoma cells | ChEMBL. | 12459014 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.