Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | glutaminyl peptide cyclotransferase | 0.0865 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0138 | 0 | 0.5 |
Trichomonas vaginalis | glutaminase, putative | 0.0289 | 0.2078 | 1 |
Loa Loa (eye worm) | glutaminase | 0.0289 | 0.2078 | 0.2078 |
Loa Loa (eye worm) | hypothetical protein | 0.0865 | 1 | 1 |
Schistosoma mansoni | glutaminase | 0.0289 | 0.2078 | 0.2078 |
Loa Loa (eye worm) | hypothetical protein | 0.0245 | 0.1477 | 0.1477 |
Brugia malayi | hypothetical protein | 0.0245 | 0.1477 | 0.1477 |
Loa Loa (eye worm) | glutaminase 2 | 0.0289 | 0.2078 | 0.2078 |
Toxoplasma gondii | peptidase, M28 family protein | 0.0138 | 0 | 0.5 |
Trypanosoma brucei | glutaminyl cyclase, putative | 0.0138 | 0 | 0.5 |
Echinococcus multilocularis | glutaminyl peptide cyclotransferase | 0.0865 | 1 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0138 | 0 | 0.5 |
Mycobacterium ulcerans | glutaminase | 0.0289 | 0.2078 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0138 | 0 | 0.5 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0245 | 0.1477 | 0.1477 |
Brugia malayi | glutaminase DH11.1 | 0.0289 | 0.2078 | 0.2078 |
Leishmania major | glutaminyl cyclase, putative | 0.0138 | 0 | 0.5 |
Onchocerca volvulus | Glutaminyl cyclase homolog | 0.0865 | 1 | 1 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0245 | 0.1477 | 0.1477 |
Mycobacterium tuberculosis | Probable lipoprotein aminopeptidase LpqL | 0.0138 | 0 | 0.5 |
Schistosoma mansoni | glutaminyl cyclase (M28 family) | 0.0865 | 1 | 1 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0138 | 0 | 0.5 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0138 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 3 nM | In vitro cytotoxicity of compound against human A431 (epidermoid) cancer cell line after 72 hr of drug exposure | ChEMBL. | 12477344 |
IC50 (functional) | > 3 nM | In vitro cytotoxicity of compound against human A549 (non small cell lung) cancer cell line after 72 hr of drug exposure | ChEMBL. | 12477344 |
IC50 (functional) | > 3 nM | Cytotoxic effect on A431 cell proliferation after 72 hr | ChEMBL. | 15225730 |
IC50 (functional) | > 3 nM | Compound was tested for its cytotoxicity by inhibiting the growth of A-549 cell line after 72 h | ChEMBL. | 15225730 |
IC50 (functional) | > 3 nM | In vitro cytotoxicity of compound against human A431 (epidermoid) cancer cell line after 72 hr of drug exposure | ChEMBL. | 12477344 |
IC50 (functional) | > 3 nM | In vitro cytotoxicity of compound against human A549 (non small cell lung) cancer cell line after 72 hr of drug exposure | ChEMBL. | 12477344 |
IC50 (functional) | > 3 nM | Cytotoxic effect on A431 cell proliferation after 72 hr | ChEMBL. | 15225730 |
IC50 (functional) | > 3 nM | Compound was tested for its cytotoxicity by inhibiting the growth of A-549 cell line after 72 h | ChEMBL. | 15225730 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 12477344 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.