Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | alanyl (membrane) aminopeptidase | Starlite/ChEMBL | References |
Homo sapiens | dipeptidyl-peptidase 4 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | puromycin sensitive aminopeptidase | alanyl (membrane) aminopeptidase | 967 aa | 976 aa | 28.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | calcium:calmodulin dependent 3'5' cyclic | 0.0196 | 0.9149 | 0.907 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.007 | 0.1067 | 1 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.0209 | 1 | 1 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.0209 | 1 | 1 |
Echinococcus multilocularis | calcium:calmodulin dependent 3',5' cyclic | 0.0196 | 0.9149 | 0.907 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.007 | 0.1067 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.3039 | 0.3039 |
Echinococcus granulosus | aminopeptidase N | 0.0143 | 0.5749 | 0.5357 |
Brugia malayi | Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative | 0.0196 | 0.9149 | 0.9149 |
Schistosoma mansoni | calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase | 0.0196 | 0.9149 | 0.9047 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.0116 | 0.3992 | 0.3992 |
Brugia malayi | prolyl oligopeptidase family protein | 0.007 | 0.1067 | 0.1067 |
Echinococcus multilocularis | aminopeptidase N | 0.0143 | 0.5749 | 0.5357 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.4796 | 0.4796 |
Plasmodium vivax | 3',5'-cyclic nucleotide phosphodiesterase, putative | 0.0067 | 0.0844 | 0.5 |
Echinococcus multilocularis | Dipeptidyl peptidase 9 | 0.007 | 0.1067 | 0.0243 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.007 | 0.1067 | 1 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.0209 | 1 | 1 |
Toxoplasma gondii | dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein | 0.007 | 0.1067 | 1 |
Loa Loa (eye worm) | PDE1B protein | 0.0196 | 0.9149 | 0.9149 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0209 | 1 | 1 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.007 | 0.1067 | 1 |
Echinococcus granulosus | Dipeptidyl peptidase 9 | 0.007 | 0.1067 | 0.0243 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.007 | 0.1067 | 1 |
Brugia malayi | Peptidase family M1 containing protein | 0.0143 | 0.5749 | 0.5749 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.0209 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 11.4 ug ml-1 | Inhibitory activity against aminopeptidase N (APN) in human acute lymphoblastic leukemia MOLT-4 cell line | ChEMBL. | 10098663 |
IC50 (binding) | = 11.4 ug ml-1 | Inhibitory activity against aminopeptidase N (APN) in human acute lymphoblastic leukemia MOLT-4 cell line | ChEMBL. | 10098663 |
IC50 (binding) | = 12 ug ml-1 | Inhibitory activity against Dipeptidyl-peptidase IV (DPP IV) in human acute lymphoblastic leukemia MOLT-4 cell line | ChEMBL. | 10098663 |
IC50 (binding) | = 12 ug ml-1 | Inhibitory activity against Dipeptidyl-peptidase IV (DPP IV) in human acute lymphoblastic leukemia MOLT-4 cell line | ChEMBL. | 10098663 |
IC50 (functional) | > 100 ug ml-1 | Cytotoxicity in human embryonic lung flbroblast Wl-38 cells using WST-1 viability assay | ChEMBL. | 10098663 |
IC50 (binding) | = 28.8 uM | Inhibitory activity against aminopeptidase N (APN) in human acute lymphoblastic leukemia MOLT-4 cell line | ChEMBL. | 10098663 |
IC50 (binding) | = 28.8 uM | Inhibitory activity against aminopeptidase N (APN) in human acute lymphoblastic leukemia MOLT-4 cell line | ChEMBL. | 10098663 |
IC50 (binding) | = 30.4 uM | Inhibitory activity against Dipeptidyl-peptidase IV (DPP IV) in human acute lymphoblastic leukemia MOLT-4 cell line | ChEMBL. | 10098663 |
IC50 (binding) | = 30.4 uM | Inhibitory activity against Dipeptidyl-peptidase IV (DPP IV) in human acute lymphoblastic leukemia MOLT-4 cell line | ChEMBL. | 10098663 |
IC50 (functional) | > 252.9 uM | Cytotoxicity in human embryonic lung flbroblast Wl-38 cells using WST-1 viability assay | ChEMBL. | 10098663 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.