Detailed information for compound 264899

Basic information

Technical information
  • TDR Targets ID: 264899
  • Name: 2-[2-[3-(4-methylphenyl)-3-phenylpropyl]-1H-i midazol-5-yl]ethanamine
  • MW: 319.443 | Formula: C21H25N3
  • H donors: 2 H acceptors: 1 LogP: 3.84 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: NCCc1c[nH]c(n1)CCC(c1ccc(cc1)C)c1ccccc1
  • InChi: 1S/C21H25N3/c1-16-7-9-18(10-8-16)20(17-5-3-2-4-6-17)11-12-21-23-15-19(24-21)13-14-22/h2-10,15,20H,11-14,22H2,1H3,(H,23,24)
  • InChiKey: QZYRMAITXZSSGA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[2-[3-phenyl-3-(p-tolyl)propyl]-1H-imidazol-5-yl]ethanamine
  • 2-[2-[3-(4-methylphenyl)-3-phenyl-propyl]-1H-imidazol-5-yl]ethanamine
  • 2-[2-[3-phenyl-3-(p-tolyl)propyl]-1H-imidazol-5-yl]ethylamine
  • 2-[2-[3-(4-methylphenyl)-3-phenylpropyl]-3H-imidazol-4-yl]ethanamine
  • 2-[2-[3-(4-methylphenyl)-3-phenyl-propyl]-3H-imidazol-4-yl]ethanamine
  • 2-[2-[3-(4-methylphenyl)-3-phenyl-propyl]-3H-imidazol-4-yl]ethylamine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.007 0.1931 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0024 0.0277 0.0216
Echinococcus multilocularis neuropeptides capa receptor 0.0024 0.0277 0.0216
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0024 0.0277 0.0216
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0024 0.0277 0.0216
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0318 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0024 0.0277 0.0097
Plasmodium falciparum LCCL domain-containing protein 0.0021 0.0183 0.3638
Echinococcus granulosus orexin receptor type 2 0.0024 0.0277 0.0216
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0024 0.0277 0.0174
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0024 0.0277 0.0097
Schistosoma mansoni amine GPCR 0.0024 0.0277 0.0097
Echinococcus multilocularis G protein coupled receptor 139 0.0024 0.0277 0.0216
Brugia malayi Doublecortin family protein 0.0021 0.0183 0.0183
Echinococcus multilocularis CREB binding protein 0.0074 0.2105 0.2055
Echinococcus granulosus neuropeptide Y receptor 0.0024 0.0277 0.0216
Echinococcus multilocularis orexin receptor type 2 0.0024 0.0277 0.0216
Schistosoma mansoni adenoreceptor 0.0024 0.0277 0.0097
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0337 0.0118
Loa Loa (eye worm) PDE1B protein 0.0204 0.6775 0.6741
Brugia malayi putative neuropeptide receptor 0.0024 0.0277 0.0277
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0024 0.0277 0.0097
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0277 0.0216
Brugia malayi TAZ zinc finger family protein 0.0108 0.3335 0.3335
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0337 1
Loa Loa (eye worm) neuropeptide F receptor 0.0024 0.0277 0.0174
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0024 0.0277 0.0216
Loa Loa (eye worm) hypothetical protein 0.0024 0.0277 0.0174
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0277 0.0216
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0337 1
Brugia malayi Dopamine receptor protein 1 0.0024 0.0277 0.0277
Echinococcus multilocularis RUN 0.0021 0.0183 0.012
Loa Loa (eye worm) G-protein coupled receptor 0.0024 0.0277 0.0174
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0024 0.0277 0.0216
Echinococcus granulosus neuropeptides capa receptor 0.0024 0.0277 0.0216
Schistosoma mansoni amine GPCR 0.0024 0.0277 0.0097
Echinococcus granulosus neuropeptide receptor A26 0.0024 0.0277 0.0216
Loa Loa (eye worm) hypothetical protein 0.0024 0.0277 0.0174
Onchocerca volvulus 0.0024 0.0277 0.0097
Loa Loa (eye worm) hypothetical protein 0.0024 0.0277 0.0174
Echinococcus granulosus neuropeptide Y receptor 0.0024 0.0277 0.0216
Echinococcus granulosus peptide allatostatin:somatostatin 0.0024 0.0277 0.0216
Echinococcus granulosus RUN 0.0021 0.0183 0.012
Echinococcus granulosus tm gpcr rhodopsin 0.0024 0.0277 0.0216
Schistosoma mansoni neuropeptide receptor 0.0024 0.0277 0.0097
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0277 0.0216
Loa Loa (eye worm) hypothetical protein 0.0024 0.0277 0.0174
Brugia malayi hypothetical protein 0.0024 0.0277 0.0277
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0337 0.5
Brugia malayi RE15519p 0.0024 0.0277 0.0277
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0337 0.0337
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0277 0.0216
Schistosoma mansoni biogenic amine receptor 0.0024 0.0277 0.0097
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0277 0.0097
Loa Loa (eye worm) hypothetical protein 0.0024 0.0277 0.0174
Echinococcus granulosus tachykinin peptides receptor 99D 0.0024 0.0277 0.0216
Brugia malayi Serotonin receptor 0.0024 0.0277 0.0277
Loa Loa (eye worm) hypothetical protein 0.0024 0.0277 0.0174
Loa Loa (eye worm) hypothetical protein 0.0024 0.0277 0.0174
Loa Loa (eye worm) hypothetical protein 0.0024 0.0277 0.0174
Echinococcus granulosus CREB binding protein 0.0067 0.1835 0.1783
Echinococcus granulosus g protein coupled receptor 0.0024 0.0277 0.0216
Schistosoma mansoni biogenic amine (5HT) receptor 0.0024 0.0277 0.0097
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0277 0.0097
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0337 0.0118
Echinococcus granulosus tm gpcr rhodopsin 0.0024 0.0277 0.0216
Echinococcus granulosus serotonin receptor 0.0024 0.0277 0.0216
Brugia malayi Serotonin receptor 0.0024 0.0277 0.0277
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.007 0.1931 0.188
Loa Loa (eye worm) hypothetical protein 0.0051 0.1259 0.1166
Onchocerca volvulus 0.0025 0.0337 0.0157
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0293 1 1
Onchocerca volvulus 0.0024 0.0277 0.0097
Brugia malayi GnHR receptor homolog 0.0024 0.0277 0.0277
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0277 0.0097
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.007 0.1931 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0277 0.0216
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0024 0.0277 0.0097
Echinococcus multilocularis neuropeptide receptor 0.0024 0.0277 0.0216
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0024 0.0277 0.0216
Loa Loa (eye worm) hypothetical protein 0.0024 0.0277 0.0174
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0024 0.0277 0.0216
Echinococcus granulosus neuropeptide receptor 0.0024 0.0277 0.0216
Onchocerca volvulus 0.0024 0.0277 0.0097
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0318 1
Schistosoma mansoni opsin-like receptor 0.0024 0.0277 0.0097
Schistosoma mansoni myosin xvIII 0.0024 0.0277 0.0097
Echinococcus granulosus allatostatin A receptor 0.0024 0.0277 0.0216
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0183 0.012
Loa Loa (eye worm) hypothetical protein 0.0024 0.0277 0.0174
Brugia malayi putative neuropeptide receptor NPR1 0.0024 0.0277 0.0277
Loa Loa (eye worm) melatonin receptor type 1A 0.0024 0.0277 0.0174
Onchocerca volvulus 0.0024 0.0277 0.0097
Plasmodium vivax multidomain scavenger receptor, putative 0.0021 0.0183 0.0423
Loa Loa (eye worm) hypothetical protein 0.0024 0.0277 0.0174
Schistosoma mansoni biogenic amine (5HT) receptor 0.0024 0.0277 0.0097
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0024 0.0277 0.0097
Onchocerca volvulus 0.0024 0.0277 0.0097
Schistosoma mansoni neuropeptide F-like receptor 0.0024 0.0277 0.0097
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0024 0.0277 0.0097
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0337 1
Echinococcus multilocularis neuropeptide receptor 0.0024 0.0277 0.0216
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0337 0.5
Onchocerca volvulus 0.0024 0.0277 0.0097
Loa Loa (eye worm) doublecortin family protein 0.0021 0.0183 0.0078
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0024 0.0277 0.0216
Echinococcus granulosus g protein coupled receptor 0.0024 0.0277 0.0216
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0277 0.0216
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0024 0.0277 0.0174
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0024 0.0277 0.0174
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0024 0.0277 0.0216
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0277 0.0216
Loa Loa (eye worm) hypothetical protein 0.0024 0.0277 0.0174
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0337 0.0337
Brugia malayi Melatonin receptor type 1A 0.0024 0.0277 0.0277
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0024 0.0277 0.0097
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0337 1
Echinococcus granulosus Polycystic kidney disease protein 0.0021 0.0183 0.012
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0337 0.5
Loa Loa (eye worm) hypothetical protein 0.0024 0.0277 0.0174
Brugia malayi AKH receptor 0.0024 0.0277 0.0277
Loa Loa (eye worm) hypothetical protein 0.0024 0.0277 0.0174
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0337 1
Echinococcus multilocularis fmrfamide receptor 0.0024 0.0277 0.0216
Echinococcus granulosus g-protein coupled receptor 0.0024 0.0277 0.0216
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.007 0.1931 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0277 0.0097
Loa Loa (eye worm) G-protein coupled receptor 0.0024 0.0277 0.0174
Brugia malayi RNA recognition motif domain containing protein 0.0068 0.1867 0.1867
Loa Loa (eye worm) hypothetical protein 0.0024 0.0277 0.0174
Echinococcus granulosus sex peptide receptor 0.0024 0.0277 0.0216
Loa Loa (eye worm) hypothetical protein 0.0024 0.0277 0.0174
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.007 0.1931 0.188
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0204 0.6775 0.6715
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0024 0.0277 0.0216
Loa Loa (eye worm) hypothetical protein 0.0024 0.0277 0.0174
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0204 0.6775 0.6755
Schistosoma mansoni alpha-1 adrenergic receptor 0.0024 0.0277 0.0097
Echinococcus multilocularis somatostatin receptor 0.0024 0.0277 0.0216
Schistosoma mansoni amine GPCR 0.0024 0.0277 0.0097
Echinococcus granulosus g protein coupled receptor 0.0024 0.0277 0.0216
Echinococcus granulosus neuropeptide receptor 0.0024 0.0277 0.0216
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0337 1
Echinococcus multilocularis g protein coupled receptor 0.0024 0.0277 0.0216
Loa Loa (eye worm) hypothetical protein 0.0024 0.0277 0.0174
Echinococcus multilocularis G-protein coupled receptor, putative 0.0024 0.0277 0.0216
Brugia malayi hypothetical protein 0.0024 0.0277 0.0277
Echinococcus granulosus neuropeptides capa receptor 0.0024 0.0277 0.0216
Echinococcus granulosus alpha 1A adrenergic receptor 0.0024 0.0277 0.0216
Loa Loa (eye worm) hypothetical protein 0.0025 0.0318 0.0215
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0277 0.0216
Echinococcus multilocularis g protein coupled receptor 0.0024 0.0277 0.0216
Schistosoma mansoni growth hormone secretagogue receptor 0.0024 0.0277 0.0097
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0277 0.0216
Loa Loa (eye worm) hypothetical protein 0.0024 0.0277 0.0174
Onchocerca volvulus 0.0024 0.0277 0.0097
Brugia malayi G-protein coupled receptor 0.0024 0.0277 0.0277
Brugia malayi larval opioid receptor 0.0024 0.0277 0.0277
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0204 0.6775 0.6775
Echinococcus multilocularis neuropeptide Y receptor 0.0024 0.0277 0.0216
Loa Loa (eye worm) hypothetical protein 0.0024 0.0277 0.0174
Loa Loa (eye worm) TAR-binding protein 0.0068 0.1867 0.178
Loa Loa (eye worm) hypothetical protein 0.0024 0.0277 0.0174
Echinococcus multilocularis fmrfamide receptor 0.0024 0.0277 0.0216
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0277 0.0216
Onchocerca volvulus 0.0024 0.0277 0.0097
Loa Loa (eye worm) hypothetical protein 0.0021 0.0183 0.0078
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0024 0.0277 0.0216
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0024 0.0277 0.0174
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0019 0.0105 0.5
Schistosoma mansoni histamine h1 receptor 0.0024 0.0277 0.0097
Echinococcus multilocularis neuropeptide Y receptor 0.0024 0.0277 0.0216
Echinococcus multilocularis neuropeptide receptor A26 0.0024 0.0277 0.0216
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0204 0.6775 0.6755
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0024 0.0277 0.0216
Schistosoma mansoni tar DNA-binding protein 0.0068 0.1867 0.1716
Echinococcus multilocularis allatostatin A receptor 0.0024 0.0277 0.0216
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0277 0.0216
Brugia malayi hypothetical protein 0.0024 0.0277 0.0277
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0024 0.0277 0.0097
Brugia malayi Dopamine receptor 0.0024 0.0277 0.0277
Loa Loa (eye worm) hypothetical protein 0.0024 0.0277 0.0174
Brugia malayi G-protein coupled receptor 0.0024 0.0277 0.0277
Echinococcus granulosus dro:myosuppressin receptor 0.0024 0.0277 0.0216
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0277 0.0216
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0277 0.0097
Schistosoma mansoni amine GPCR 0.0024 0.0277 0.0097
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0024 0.0277 0.0216
Schistosoma mansoni biogenic amine receptor 0.0024 0.0277 0.0097
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0024 0.0277 0.0216
Onchocerca volvulus Neuropeptide F receptor homolog 0.0024 0.0277 0.0097
Loa Loa (eye worm) neuropeptide F receptor 0.0024 0.0277 0.0174
Loa Loa (eye worm) hypothetical protein 0.0024 0.0277 0.0174
Onchocerca volvulus 0.0024 0.0277 0.0097
Loa Loa (eye worm) hypothetical protein 0.0024 0.0277 0.0174
Loa Loa (eye worm) hypothetical protein 0.0024 0.0277 0.0174
Brugia malayi Tachykinin-like peptides receptor 99D 0.0024 0.0277 0.0277
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.007 0.1931 1
Brugia malayi neuropeptide F receptor 0.0024 0.0277 0.0277
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0024 0.0277 0.0097
Echinococcus multilocularis serotonin receptor 0.0024 0.0277 0.0216
Brugia malayi hypothetical protein 0.0024 0.0277 0.0277
Loa Loa (eye worm) hypothetical protein 0.0024 0.0277 0.0174
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0068 0.1867 0.178
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0059 0.1553 0.1499
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0293 1 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0183 0.012
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0024 0.0277 0.0277
Loa Loa (eye worm) RNA binding protein 0.0068 0.1867 0.178
Echinococcus multilocularis serotonin receptor 0.0024 0.0277 0.0216
Echinococcus granulosus 7TM GPCR rhodopsin 0.0024 0.0277 0.0216
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0059 0.1553 0.1499
Echinococcus granulosus tar DNA binding protein 0.0068 0.1867 0.1816
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.007 0.1931 1
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0293 1 1
Echinococcus granulosus somatostatin receptor 0.0024 0.0277 0.0216
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0337 1
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0293 1 1
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0293 1 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.027 0.9158 0.9149
Brugia malayi hypothetical protein 0.0024 0.0277 0.0277
Echinococcus granulosus biogenic amine 5HT receptor 0.0024 0.0277 0.0216
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0024 0.0277 0.0097
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0277 0.0097
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0024 0.0277 0.0277
Loa Loa (eye worm) hypothetical protein 0.0024 0.0277 0.0174
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0105 0.139
Brugia malayi follicle stimulating hormone receptor 0.027 0.9158 0.9158
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0024 0.0277 0.0277
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0024 0.0277 0.0216
Echinococcus granulosus hypothetical protein 0.0024 0.0277 0.0216
Echinococcus granulosus fmrfamide receptor 0.0024 0.0277 0.0216
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0024 0.0277 0.0216
Echinococcus granulosus CREB binding protein 0.0108 0.3335 0.3292
Schistosoma mansoni biogenic amine receptor 0.0024 0.0277 0.0097
Brugia malayi hypothetical protein 0.0024 0.0277 0.0277
Echinococcus granulosus neuropeptide FF receptor 2 0.0024 0.0277 0.0216
Loa Loa (eye worm) hypothetical protein 0.0024 0.0277 0.0174
Brugia malayi hypothetical protein 0.0024 0.0277 0.0277
Brugia malayi TAR-binding protein 0.0068 0.1867 0.1867
Schistosoma mansoni neuropeptide F-like receptor 0.0024 0.0277 0.0097
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0024 0.0277 0.0097
Schistosoma mansoni tar DNA-binding protein 0.0068 0.1867 0.1716
Loa Loa (eye worm) hypothetical protein 0.0024 0.0277 0.0174
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0277 0.0216
Loa Loa (eye worm) hypothetical protein 0.0021 0.0183 0.0078
Loa Loa (eye worm) hypothetical protein 0.0024 0.0277 0.0174
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0337 0.5
Schistosoma mansoni neuropeptide receptor 0.0024 0.0277 0.0097
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0024 0.0277 0.0097
Loa Loa (eye worm) CBP-B 0.0075 0.2139 0.2055
Echinococcus granulosus biogenic amine 5HT receptor 0.0024 0.0277 0.0216
Schistosoma mansoni lipoxygenase 0.0059 0.1553 0.1396
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0024 0.0277 0.0216
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0277 0.0216
Loa Loa (eye worm) hypothetical protein 0.0025 0.0337 0.0234
Schistosoma mansoni tar DNA-binding protein 0.0068 0.1867 0.1716
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0277 0.0097
Onchocerca volvulus 0.0024 0.0277 0.0097
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.007 0.1931 1
Brugia malayi hypothetical protein 0.0025 0.0318 0.0318
Schistosoma mansoni amine GPCR 0.0024 0.0277 0.0097
Brugia malayi RNA binding protein 0.0068 0.1867 0.1867
Schistosoma mansoni serine/threonine protein kinase 0.0293 1 1
Brugia malayi neuropeptide F receptor 0.0024 0.0277 0.0277
Echinococcus granulosus G protein coupled receptor 139 0.0024 0.0277 0.0216
Echinococcus granulosus neuropeptide s receptor 0.0024 0.0277 0.0216
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0024 0.0277 0.0216
Brugia malayi ORL1-like opioid receptor 0.0024 0.0277 0.0277
Loa Loa (eye worm) hypothetical protein 0.0024 0.0277 0.0174
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0337 1
Mycobacterium ulcerans hypothetical protein 0.0025 0.0337 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0337 0.0234
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0293 1 1
Schistosoma mansoni neuropeptide f receptor 76f 0.0024 0.0277 0.0097
Schistosoma mansoni neuropeptide receptor 0.0024 0.0277 0.0097
Schistosoma mansoni CREB-binding protein 1 (SmCBP1) 0.0108 0.3335 0.3211
Schistosoma mansoni hypothetical protein 0.0024 0.0277 0.0097
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0024 0.0277 0.0216
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0337 0.0118
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0024 0.0277 0.0097
Loa Loa (eye worm) hypothetical protein 0.0024 0.0277 0.0174
Echinococcus multilocularis g-protein coupled receptor 0.0024 0.0277 0.0216
Brugia malayi hypothetical protein 0.0024 0.0277 0.0277
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0024 0.0277 0.0277
Schistosoma mansoni tar DNA-binding protein 0.0068 0.1867 0.1716
Brugia malayi hypothetical protein 0.0024 0.0277 0.0277
Schistosoma mansoni neuropeptide receptor 0.0024 0.0277 0.0097
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0337 0.0337
Loa Loa (eye worm) hypothetical protein 0.0025 0.0337 0.0234
Echinococcus multilocularis Polycystic kidney disease protein 0.0021 0.0183 0.012
Schistosoma mansoni tar DNA-binding protein 0.0068 0.1867 0.1716
Brugia malayi hypothetical protein 0.0024 0.0277 0.0277
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0277 0.0216
Onchocerca volvulus 0.0024 0.0277 0.0097
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0183 0.012
Loa Loa (eye worm) hypothetical protein 0.0024 0.0277 0.0174
Loa Loa (eye worm) hypothetical protein 0.0024 0.0277 0.0174
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0024 0.0277 0.0097
Loa Loa (eye worm) hypothetical protein 0.0024 0.0277 0.0174
Loa Loa (eye worm) hypothetical protein 0.0024 0.0277 0.0174
Echinococcus multilocularis tar DNA binding protein 0.0068 0.1867 0.1816
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0183 0.012
Echinococcus multilocularis neuropeptide FF receptor 2 0.0024 0.0277 0.0216
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0337 0.5
Echinococcus multilocularis neuropeptides capa receptor 0.0024 0.0277 0.0216
Echinococcus multilocularis g protein coupled receptor 0.0024 0.0277 0.0216
Brugia malayi G protein-coupled receptor 0.0024 0.0277 0.0277
Onchocerca volvulus 0.0024 0.0277 0.0097
Echinococcus granulosus 7tm_1 domain containing protein 0.0024 0.0277 0.0216
Echinococcus multilocularis sex peptide receptor 0.0024 0.0277 0.0216
Schistosoma mansoni CREB-binding protein 2 0.0108 0.3335 0.3211
Echinococcus granulosus tm gpcr rhodopsin 0.0024 0.0277 0.0216
Echinococcus multilocularis dro:myosuppressin receptor 0.0024 0.0277 0.0216
Brugia malayi hypothetical protein 0.0021 0.0183 0.0183
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0277 0.0097
Onchocerca volvulus 0.0024 0.0277 0.0097
Loa Loa (eye worm) hypothetical protein 0.0024 0.0277 0.0174
Loa Loa (eye worm) hypothetical protein 0.0024 0.0277 0.0174
Brugia malayi sulfakinin receptor protein 0.0024 0.0277 0.0277
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0024 0.0277 0.0216
Loa Loa (eye worm) hypothetical protein 0.0024 0.0277 0.0174
Loa Loa (eye worm) hypothetical protein 0.0024 0.0277 0.0174
Schistosoma mansoni opsin-like receptor 0.0024 0.0277 0.0097
Onchocerca volvulus 0.0024 0.0277 0.0097
Schistosoma mansoni opsin-like receptor 0.0024 0.0277 0.0097
Echinococcus multilocularis neuropeptide s receptor 0.0024 0.0277 0.0216
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0024 0.0277 0.0277
Brugia malayi Dopamine receptor protein 2 0.0024 0.0277 0.0277
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0337 1
Schistosoma mansoni hypothetical protein 0.0024 0.0277 0.0097
Onchocerca volvulus 0.0024 0.0277 0.0097
Schistosoma mansoni hypothetical protein 0.0024 0.0277 0.0097
Loa Loa (eye worm) hypothetical protein 0.0024 0.0277 0.0174
Brugia malayi hypothetical protein 0.0021 0.0183 0.0183
Loa Loa (eye worm) hypothetical protein 0.0024 0.0277 0.0174
Schistosoma mansoni hypothetical protein 0.0024 0.0277 0.0097
Onchocerca volvulus 0.0024 0.0277 0.0097
Onchocerca volvulus 0.0024 0.0277 0.0097
Loa Loa (eye worm) TYRA-2 protein 0.0024 0.0277 0.0174
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.007 0.1931 1
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0318 0.1163
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0277 0.0097
Loa Loa (eye worm) hypothetical protein 0.0024 0.0277 0.0174
Loa Loa (eye worm) hypothetical protein 0.0024 0.0277 0.0174
Brugia malayi G protein-coupled receptor F59B2.13 0.0024 0.0277 0.0277
Loa Loa (eye worm) hypothetical protein 0.0024 0.0277 0.0174

Activities

Activity type Activity value Assay description Source Reference
Alpha (binding) Intrinsic activity of the compound was determined ;Tested up to 10 microM: no effects up to 1 microM ChEMBL. 14667234
Alpha (binding) 0 Intrinsic activity of the compound was determined ;Tested up to 10 microM: no effects up to 1 microM ChEMBL. 14667234
Ki (binding) = 5.5 Inhibitory activity against human Histamine H1 receptor ChEMBL. 14667234
Log IC50 (binding) Inhibition of human histamine H1 receptor ChEMBL. 14667234
Log IC50 (binding) 0 Inhibition of human histamine H1 receptor ChEMBL. 14667234
Log Ki (binding) = 5.5 Inhibitory activity against human Histamine H1 receptor ChEMBL. 14667234

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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