Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | acetylcholinesterase (Yt blood group) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | acetylcholinesterase (Yt blood group) | 614 aa | 510 aa | 26.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | hypothetical protein | 0.6412 | 1 | 0.5 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.0434 | 0 | 0.5 |
Trypanosoma brucei | oxidoreductase-like protein | 0.0434 | 0 | 0.5 |
Leishmania major | oxidoreductase-like protein | 0.0434 | 0 | 0.5 |
Leishmania major | dehydrogenase/oxidoreductase-like protein | 0.0434 | 0 | 0.5 |
Leishmania major | pteridine reductase 1 | 0.0434 | 0 | 0.5 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.6412 | 1 | 1 |
Trypanosoma cruzi | oxidoreductase-like protein, putative | 0.0434 | 0 | 0.5 |
Entamoeba histolytica | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0434 | 0 | 0.5 |
Schistosoma mansoni | dihydropteridine reductase | 0.0434 | 0 | 0.5 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.6412 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0434 | 0 | 0.5 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0434 | 0 | 0.5 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0434 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0434 | 0 | 0.5 |
Leishmania major | dehydrogenase/oxidoreductase-like protein | 0.0434 | 0 | 0.5 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.6412 | 1 | 1 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.6412 | 1 | 1 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.6412 | 1 | 1 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.6412 | 1 | 1 |
Trypanosoma brucei | pteridine reductase 1 | 0.0434 | 0 | 0.5 |
Loa Loa (eye worm) | retinol dehydrogenase 12 | 0.0434 | 0 | 0.5 |
Trypanosoma brucei | beta-ketoacyl-ACP reductase | 0.0434 | 0 | 0.5 |
Onchocerca volvulus | 0.0434 | 0 | 0.5 | |
Echinococcus multilocularis | 3 oxoacyl acyl carrier protein reductase | 0.0434 | 0 | 0.5 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.0434 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.6412 | 1 | 1 |
Onchocerca volvulus | 0.0434 | 0 | 0.5 | |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0434 | 0 | 0.5 |
Echinococcus granulosus | 3 oxoacyl acyl carrier protein reductase | 0.0434 | 0 | 0.5 |
Leishmania major | 3-oxoacyl-ACP reductase, putative | 0.0434 | 0 | 0.5 |
Schistosoma mansoni | 3-oxoacyl-[ACP] reductase | 0.0434 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
-Log IC50 (binding) | = 8.15 | Inhibition of acetylcholinesterase. | ChEMBL. | 1738151 |
IC50 (binding) | = 8.15 | Inhibition of acetylcholinesterase. | ChEMBL. | 1738151 |
IC50 (binding) | = 380 nM | IC50 against acetylcholinesterase; value ranges from 1.3-380 nM. | ChEMBL. | 1738151 |
IC50 (binding) | = 380 nM | IC50 against acetylcholinesterase; value ranges from 1.3-380 nM. | ChEMBL. | 1738151 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.