Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0051 | 0.0371 | 0.9112 | |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.0947 | 0.5172 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.019 | 0.337 | 0.5 |
Echinococcus granulosus | endothelin converting enzyme 1 | 0.0102 | 0.1484 | 1 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0102 | 0.1484 | 1 |
Trypanosoma brucei | Polypeptide deformylase 1 | 0.019 | 0.337 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0908 | 0.4828 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.1484 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.0947 | 0.5172 |
Plasmodium falciparum | peptide deformylase | 0.0497 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | peptide deformylase | 0.0497 | 1 | 0.5 |
Brugia malayi | Matrixin family protein | 0.0057 | 0.0509 | 0.343 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0908 | 0.4828 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.0947 | 0.5172 |
Brugia malayi | Hypothetical zinc metalloproteinase T16A9.4 | 0.0102 | 0.1484 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0908 | 0.4828 |
Loa Loa (eye worm) | matrixin family protein | 0.0052 | 0.0407 | 0.0325 |
Onchocerca volvulus | Matrilysin homolog | 0.0052 | 0.0407 | 1 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0052 | 0.0391 | 0.2636 |
Leishmania major | polypeptide deformylase-like protein, putative | 0.019 | 0.337 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.0947 | 0.5172 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.1484 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.1484 | 1 |
Mycobacterium tuberculosis | Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) | 0.0497 | 1 | 1 |
Schistosoma mansoni | family M13 non-peptidase homologue (M13 family) | 0.0052 | 0.0391 | 0.2636 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.0947 | 0.5172 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.019 | 0.337 | 0.5 |
Brugia malayi | Peptidase family M13 containing protein | 0.0102 | 0.1484 | 1 |
Echinococcus multilocularis | endothelin converting enzyme 1 | 0.0102 | 0.1484 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0497 | 1 | 1 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0076 | 0.0908 | 0.4828 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.019 | 0.337 | 0.5 |
Schistosoma mansoni | Nep2 peptidase (M13 family) | 0.0052 | 0.0391 | 0.2636 |
Plasmodium vivax | peptide deformylase, putative | 0.0497 | 1 | 0.5 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0076 | 0.0908 | 0.4828 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0908 | 0.4828 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.0947 | 0.5172 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0052 | 0.0391 | 0.2636 |
Treponema pallidum | polypeptide deformylase (def) | 0.0497 | 1 | 0.5 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0052 | 0.0407 | 1 |
Loa Loa (eye worm) | matrixin family protein | 0.0057 | 0.0509 | 0.124 |
Trypanosoma brucei | Peptide deformylase 2 | 0.019 | 0.337 | 0.5 |
Schistosoma mansoni | neprilysin-2 (M13 family) | 0.0052 | 0.0391 | 0.2636 |
Mycobacterium leprae | PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) | 0.0497 | 1 | 1 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.019 | 0.337 | 0.5 |
Mycobacterium ulcerans | peptide deformylase | 0.0497 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 96 % | Inhibition of tumor promoter (TPA) -induced mouse epidermal ornithine decarboxylase (ODC) activity at 17 nmol dose level | ChEMBL. | 7241516 |
Inhibition (functional) | = 96 % | Inhibition of tumor promoter (TPA) -induced mouse epidermal ornithine decarboxylase (ODC) activity at 17 nmol dose level | ChEMBL. | 7241516 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.