TDR Targets

Basic information

Technical information

TDR Targets ID: 268101
Name: N,2,5,5-tetramethyl-N-(naphthalen-1-ylmethyl) hex-3-yn-1-amine
MW: 293.446 | Formula: C21H27N
H donors: 0 H acceptors: 0 LogP: 5.73 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: CN(Cc1cccc2c1cccc2)CC(C#CC(C)(C)C)C
InChi: 1S/C21H27N/c1-17(13-14-21(2,3)4)15-22(5)16-19-11-8-10-18-9-6-7-12-20(18)19/h6-12,17H,15-16H2,1-5H3
InChiKey: QTQZYJWLJNLMGH-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N,2,5,5-tetramethyl-N-(1-naphthylmethyl)hex-3-yn-1-amine
N,2,5,5-tetramethyl-N-(1-naphthalenylmethyl)-3-hexyn-1-amine
methyl-(1-naphthylmethyl)-(2,5,5-trimethylhex-3-ynyl)amine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	celfurPC protein	0.0136	0.095	0.2815
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.006	0.0305	0.0305
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0035	0.0091	0.0553
Toxoplasma gondii	hypothetical protein	0.0035	0.0093	0.0007
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0073	0.0444
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.004	0.0134	0.0814
Loa Loa (eye worm)	proprotein convertase 2	0.004	0.0134	0.0315
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0035	0.0091	0.0913
Echinococcus multilocularis	cysteine protease	0.0035	0.0091	0.021
Toxoplasma gondii	cathepsin B	0.0142	0.1001	0.3691
Toxoplasma gondii	PAN domain-containing protein	0.0326	0.2556	1
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0103	0.0666	0.4032
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0078	0.0454	0.1043
Schistosoma mansoni	hypothetical protein	0.0061	0.0311	0.0311
Onchocerca volvulus		0.0035	0.0091	0.0844
Onchocerca volvulus		0.0035	0.0093	0.0866
Brugia malayi	Protein kinase domain containing protein	0.0063	0.033	0.0977
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0035	0.0091	0.0913
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0035	0.0091	0.0913
Trichomonas vaginalis	neuroendocrine convertase 2 precursor, putative	0.0033	0.0073	0.0444
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0103	0.0666	0.4032
Toxoplasma gondii	PAN/Apple domain-containing protein	0.0035	0.0093	0.0007
Echinococcus granulosus	cathepsin l1	0.0035	0.0091	0.021
Giardia lamblia	Cathepsin B precursor	0.0142	0.1001	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0142	0.1001	0.2965
Loa Loa (eye worm)	TK/ROR protein kinase	0.0063	0.033	0.0898
Toxoplasma gondii	microneme protein, putative	0.0035	0.0093	0.0007
Schistosoma mansoni	tyrosine kinase	0.0078	0.0454	0.0454
Echinococcus granulosus	tissue type plasminogen activator	0.0061	0.0311	0.0714
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0078	0.0454	0.1043
Trichomonas vaginalis	leucine-rich repeat protein, BspA family	0.0033	0.0073	0.0444
Toxoplasma gondii	microneme protein MIC17C	0.0035	0.0093	0.0007
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0115	0.0768	0.0768
Plasmodium vivax	cysteine repeat modular protein 1, putative	0.0061	0.0311	1
Brugia malayi	SRC-1	0.0078	0.0454	0.1346
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0078	0.0454	0.1043
Brugia malayi	PAN domain containing protein	0.0035	0.0093	0.0276
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0035	0.0091	0.0553
Brugia malayi	Kringle domain containing protein	0.0061	0.0311	0.0922
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0035	0.0091	0.0913
Echinococcus multilocularis	calpain family protein 1, d	0.0042	0.0155	0.0355
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0228	0.0593
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0033	0.0072	0.0129
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0073	0.0444
Echinococcus multilocularis	cysteine protease	0.0035	0.0091	0.021
Loa Loa (eye worm)	endoprotease bli-4	0.0169	0.1227	0.3579
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0073	0.0444
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0035	0.0091	0.0913
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0035	0.0091	0.0553
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0078	0.0454	0.1043
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0029	0.0176
Brugia malayi	endoprotease bli-4 precursor	0.0169	0.1227	0.3635
Plasmodium vivax	vivapain-2	0.0035	0.0091	0.2936
Echinococcus multilocularis	proprotein convertase subtilisin:kexin type 5	0.0103	0.0666	0.1528
Echinococcus granulosus	tyrosine kinase	0.007	0.039	0.0895
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0035	0.0091	0.0913
Brugia malayi	PAN domain containing protein	0.0035	0.0093	0.0276
Loa Loa (eye worm)	PAN domain-containing protein	0.0035	0.0093	0.0191
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0035	0.0091	0.0186
Schistosoma mansoni	microsomal glutathione s-transferase	0.0276	0.2135	0.2135
Echinococcus granulosus	Furin 1	0.004	0.0134	0.0308
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0073	0.0444
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0093	0.0191
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.004	0.0134	0.0814
Onchocerca volvulus		0.0035	0.0091	0.0844
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0093	0.0191
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0035	0.0091	0.0553
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0033	0.0072	0.0072
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0035	0.0091	0.0553
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0035	0.0091	0.0553
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0078	0.0454	0.1043
Echinococcus granulosus	tyrosine protein kinase Blk	0.007	0.039	0.0895
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0539	0.4359	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0035	0.0091	0.0913
Schistosoma mansoni	hypothetical protein	0.0033	0.0073	0.0073
Echinococcus granulosus	tm gpcr rhodopsin	0.0539	0.4359	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0035	0.0091	0.0553
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0035	0.0091	0.021
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0093	0.0191
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0115	0.0768	0.0768
Entamoeba histolytica	protein kinase, putative	0.0062	0.0325	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0093	0.0191
Trypanosoma cruzi	cysteine peptidase, putative	0.0035	0.0091	0.0271
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0035	0.0091	0.021
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0078	0.0454	0.1043
Loa Loa (eye worm)	TK protein kinase	0.007	0.039	0.1079
Leishmania major	hypothetical protein, conserved	0.0061	0.0311	0.2417
Toxoplasma gondii	microneme protein MIC4	0.0035	0.0093	0.0007
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0142	0.1001	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0033	0.0072	0.0165
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0142	0.1001	0.6061
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0073	0.0444
Echinococcus multilocularis	cathepsin b	0.0423	0.3376	0.7744
Schistosoma mansoni	tyrosine kinase	0.0078	0.0454	0.0454
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.004	0.0134	0.0814
Onchocerca volvulus		0.0035	0.0093	0.0866
Toxoplasma gondii	MAPEG family protein	0.0276	0.2135	0.8291
Toxoplasma gondii	PAN domain-containing protein	0.0035	0.0093	0.0007
Echinococcus granulosus	calpain A	0.006	0.0305	0.0699
Onchocerca volvulus		0.0035	0.0093	0.0866
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0035	0.0091	0.0553
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0033	0.0072	0.0165
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0033	0.0072	0.0165
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.004	0.0134	0.0814
Plasmodium falciparum	cysteine repeat modular protein 1	0.0061	0.0311	1
Entamoeba histolytica	cysteine proteinase, putative	0.0027	0.0029	0.0896
Toxoplasma gondii	PAN domain-containing protein	0.0035	0.0093	0.0007
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0078	0.0454	0.1043
Echinococcus granulosus	family C2 unassigned peptidase C02 family	0.006	0.0305	0.0699
Loa Loa (eye worm)	PAN domain-containing protein	0.0035	0.0093	0.0191
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0035	0.0091	0.2936
Trypanosoma cruzi	cysteine peptidase, putative	0.0035	0.0091	0.0271
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0078	0.0454	0.1043
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0035	0.0091	0.2936
Brugia malayi	Cathepsin L-like precursor	0.0027	0.0029	0.0086
Echinococcus granulosus	cathepsin b	0.0423	0.3376	0.7744
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0358	0.0982
Onchocerca volvulus		0.0035	0.0093	0.0866
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0073	0.0444
Echinococcus multilocularis	tyrosine protein kinase Blk	0.007	0.039	0.0895
Brugia malayi	PAN domain containing protein	0.0035	0.0093	0.0276
Loa Loa (eye worm)	glutaminase	0.0219	0.1651	0.4848
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0035	0.0091	0.0553
Echinococcus granulosus	neuroendocrine convertase 2	0.0106	0.0695	0.1595
Loa Loa (eye worm)	ctsf protein	0.0035	0.0091	0.0186
Echinococcus granulosus	proprotein convertase subtilisin:kexin type 5	0.0103	0.0666	0.1528
Loa Loa (eye worm)	SRC-1	0.0078	0.0454	0.1271
Onchocerca volvulus		0.0061	0.0311	0.3821
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0073	0.0444
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0423	0.3376	1
Loa Loa (eye worm)	hypothetical protein	0.0169	0.1227	0.3579
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0035	0.0091	0.0186
Echinococcus granulosus	tyrosine protein kinase HCK	0.0062	0.0325	0.0745
Brugia malayi	PAN domain containing protein	0.0035	0.0093	0.0276
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0078	0.0454	0.1043
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0035	0.0091	0.0553
Echinococcus multilocularis	tyrosine protein kinase Srms	0.007	0.039	0.0895
Echinococcus multilocularis	neuroendocrine convertase 2	0.0106	0.0695	0.1595
Onchocerca volvulus	Cathepsin F homolog	0.0035	0.0091	0.0844
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0078	0.0454	0.1043
Trypanosoma cruzi	cruzipain precursor, putative	0.0035	0.0091	0.0271
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0035	0.0091	0.0553
Loa Loa (eye worm)	PAN domain-containing protein	0.0035	0.0093	0.0191
Onchocerca volvulus		0.0035	0.0091	0.0844
Brugia malayi	Cathepsin L-like precursor	0.0035	0.0091	0.0271
Toxoplasma gondii	microneme protein MIC17B	0.0035	0.0093	0.0007
Echinococcus granulosus	microsomal glutathione S transferase 3	0.0276	0.2135	0.4897
Trypanosoma cruzi	cysteine peptidase, putative	0.0035	0.0091	0.0271
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0078	0.0454	0.1043
Schistosoma mansoni	cathepsin F (C01 family)	0.0035	0.0091	0.0091
Onchocerca volvulus		0.0035	0.0093	0.0866
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0035	0.0091	0.0553
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0035	0.0091	0.0913
Loa Loa (eye worm)	hypothetical protein	0.0423	0.3376	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0035	0.0091	0.021
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0311	0.0843
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0423	0.3376	0.3376
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0099	0.021
Onchocerca volvulus	Cathepsin L homolog	0.0035	0.0091	0.0844
Trichomonas vaginalis	proprotein convertase subtilisin/kexin type, putative	0.0033	0.0073	0.0444
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0093	0.0191
Echinococcus multilocularis	Furin 1	0.004	0.0134	0.0308
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0078	0.0454	0.1043
Brugia malayi	PAN domain containing protein	0.0035	0.0093	0.0276
Loa Loa (eye worm)	fibroinase	0.0035	0.0091	0.0186
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0423	0.3376	0.3376
Loa Loa (eye worm)	calpain family protein 1	0.0057	0.0283	0.0758
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0027	0.0029	0.0086
Brugia malayi	Cathepsin L-like precursor	0.0035	0.0091	0.0271
Loa Loa (eye worm)	glutaminase 2	0.0219	0.1651	0.4848
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0078	0.0454	0.1043
Loa Loa (eye worm)	cysteine protease	0.0035	0.0091	0.0186
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0035	0.0091	0.0553
Onchocerca volvulus		0.0093	0.0583	0.7494
Brugia malayi	Cathepsin L-like precursor	0.0035	0.0091	0.0271
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0093	0.0191
Echinococcus granulosus	cathepsin l1	0.0027	0.0029	0.0067
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0068	0.0372	0.0853
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0035	0.0091	0.021
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0078	0.0454	0.1043
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0142	0.1001	0.1001
Onchocerca volvulus		0.0035	0.0093	0.0866
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0035	0.0091	0.0553
Brugia malayi	Papain family cysteine protease containing protein	0.0035	0.0091	0.0271
Brugia malayi	PAN domain containing protein	0.0035	0.0093	0.0276
Brugia malayi	neuroendocrine convertase 1 precursor	0.0106	0.0695	0.206
Brugia malayi	PAN domain containing protein	0.0035	0.0093	0.0276
Echinococcus multilocularis	microsomal glutathione S transferase 3	0.0276	0.2135	0.4897
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0035	0.0091	0.0913
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0283	0.0758
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.004	0.0134	0.0814
Schistosoma mansoni	cathepsin F (C01 family)	0.0035	0.0091	0.0091
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0062	0.0325	0.0745
Onchocerca volvulus		0.0035	0.0093	0.0866
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0035	0.0091	0.0553
Loa Loa (eye worm)	cathepsin B	0.0142	0.1001	0.2904
Trypanosoma cruzi	cysteine peptidase, putative	0.0035	0.0091	0.0271
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0073	0.0444
Plasmodium vivax	vivapain-2	0.0035	0.0091	0.2936
Toxoplasma gondii	subtilisin SUB12	0.0042	0.0154	0.0255
Echinococcus granulosus	furin	0.0169	0.1227	0.2815
Onchocerca volvulus		0.0035	0.0093	0.0866
Onchocerca volvulus		0.0035	0.0091	0.0844
Onchocerca volvulus	Cathepsin L homolog	0.0035	0.0091	0.0844
Giardia lamblia	Cathepsin B precursor	0.0142	0.1001	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0033	0.0072	0.0165
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.006	0.0305	0.0305
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0035	0.0091	0.0553
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.007	0.039	0.0895
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0029	0.0176
Onchocerca volvulus		0.0035	0.0091	0.0844
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.007	0.039	0.0895
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0155	0.0375
Onchocerca volvulus		0.0115	0.0768	1
Giardia lamblia	High cysteine membrane protein Group 2	0.0063	0.0328	0.2747
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0073	0.0444
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0078	0.0454	0.1043
Onchocerca volvulus		0.0035	0.0093	0.0866
Echinococcus multilocularis	cathepsin L cysteine protease	0.0035	0.0091	0.021
Brugia malayi	calpain family protein 1	0.0057	0.0283	0.0838
Toxoplasma gondii	PAN domain-containing protein	0.0035	0.0093	0.0007
Brugia malayi	cathepsin L-like precursor	0.0027	0.0029	0.0086
Schistosoma mansoni	subfamily S8B unassigned peptidase (S08 family)	0.0169	0.1227	0.1227
Loa Loa (eye worm)	TK protein kinase	0.0062	0.0325	0.0883
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0033	0.0072	0.0072
Loa Loa (eye worm)	hypothetical protein	0.0115	0.0768	0.2207
Giardia lamblia	Cathepsin B precursor	0.0142	0.1001	1
Mycobacterium ulcerans	glutaminase	0.0219	0.1651	0.5
Echinococcus multilocularis	tissue type plasminogen activator	0.0061	0.0311	0.0714
Onchocerca volvulus		0.0036	0.0099	0.0952
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0035	0.0091	0.0553
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0423	0.3376	0.3376
Echinococcus multilocularis	cathepsin b	0.0423	0.3376	0.7744
Brugia malayi	Cathepsin L-like precursor	0.0035	0.0091	0.0271
Loa Loa (eye worm)	PAN domain-containing protein	0.0035	0.0093	0.0191
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0073	0.0444
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0035	0.0091	0.2936
Toxoplasma gondii	1,3(4)-beta-glucanase	0.0035	0.0093	0.0007
Brugia malayi	glutaminase DH11.1	0.0219	0.1651	0.4892
Toxoplasma gondii	PAN domain-containing protein	0.0326	0.2556	1
Brugia malayi	PAN domain containing protein	0.0035	0.0093	0.0276
Loa Loa (eye worm)	calpain family protein 1	0.0042	0.0155	0.0375
Brugia malayi	protein-tyrosine kinase	0.007	0.039	0.1156
Toxoplasma gondii	microneme protein MIC17A	0.0035	0.0093	0.0007
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0078	0.0454	0.1043
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0035	0.0091	0.0553
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0091	0.0186
Schistosoma mansoni	cathepsin F (C01 family)	0.0027	0.0029	0.0029
Schistosoma mansoni	glutaminase	0.0219	0.1651	0.1651
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0035	0.0091	0.0913
Entamoeba histolytica	cysteine proteinase, putative	0.0035	0.0091	0.2816
Loa Loa (eye worm)	PAN domain-containing protein	0.0035	0.0093	0.0191
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.004	0.0134	0.0814
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0033	0.0072	0.0072
Trichomonas vaginalis	glutaminase, putative	0.0219	0.1651	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0035	0.0091	0.0553
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0068	0.0372	0.0853
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0423	0.3376	0.3376
Brugia malayi	proprotein convertase 2	0.0106	0.0695	0.206
Echinococcus multilocularis	calpain A	0.006	0.0305	0.0699
Echinococcus multilocularis		0.0136	0.095	0.218
Echinococcus granulosus	cathepsin b	0.0423	0.3376	0.7744
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0035	0.0091	0.0553
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0035	0.0091	0.0913
Schistosoma mansoni	subfamily S8B non-peptidase homologue (S08 family)	0.004	0.0134	0.0134
Schistosoma mansoni	furin-1 (S08 family)	0.0074	0.0419	0.0419
Brugia malayi	calpain family protein 1	0.0057	0.0283	0.0838
Onchocerca volvulus		0.0035	0.0093	0.0866
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0035	0.0091	0.021
Entamoeba histolytica	cysteine protease, putative	0.0035	0.0091	0.2816
Brugia malayi	PAN domain containing protein	0.0035	0.0093	0.0276
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0035	0.0091	0.0553
Onchocerca volvulus		0.0035	0.0093	0.0866
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0093	0.0191
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0033	0.0072	0.0214
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0057	0.0283	0.0283
Onchocerca volvulus		0.0035	0.0091	0.0844
Toxoplasma gondii	PAN domain-containing protein	0.0035	0.0093	0.0007
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0035	0.0091	0.0553
Toxoplasma gondii	hypothetical protein	0.0035	0.0093	0.0007
Brugia malayi	Cathepsin L-like precursor	0.0035	0.0091	0.0271
Entamoeba histolytica	cysteine proteinase, putative	0.0035	0.0091	0.2816
Brugia malayi	Cathepsin L-like precursor	0.0027	0.0029	0.0086
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0073	0.0444
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0027	0.0029	0.0086
Brugia malayi	Trypsin family protein	0.0115	0.0768	0.2274
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0035	0.0091	0.0553
Brugia malayi	Cathepsin L-like precursor	0.0035	0.0091	0.0271
Trichomonas vaginalis	hypothetical protein	0.0033	0.0073	0.0444
Trypanosoma cruzi	hypothetical protein, conserved	0.0061	0.0311	0.0922
Brugia malayi	PAN domain containing protein	0.0035	0.0093	0.0276
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0078	0.0454	0.1043
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	0.006	0.0305	0.0699
Loa Loa (eye worm)	hypothetical protein	0.0115	0.0768	0.2207
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0035	0.0091	0.0553
Onchocerca volvulus		0.0035	0.0091	0.0844
Toxoplasma gondii	kringle domain-containing protein	0.0061	0.0311	0.0892
Brugia malayi	cathepsin B-like cysteine proteinase	0.0423	0.3376	1
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0142	0.1001	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0035	0.0091	0.0553

Activities

Activity type	Activity value	Assay description	Source	Reference
MIC (functional)	= 0.8 mg l-1	Tested in vitro for minimum inhibitory concentration against trichophyton mentagrophytes	ChEMBL.	8126700
MIC (functional)	= 0.8 mg l-1	Tested in vitro for minimum inhibitory concentration against microsporum canis	ChEMBL.	8126700
MIC (functional)	= 12.5 mg l-1	Tested in vitro for minimum inhibitory concentration against sporothrix schenck ii	ChEMBL.	8126700
MIC (functional)	> 200 mg l-1	Tested in vitro for minimum inhibitory concentration against Aspergillus fumigatus	ChEMBL.	8126700
MIC (functional)	> 200 mg l-1	Tested in vitro for minimum inhibitory concentration against candida albicans 124	ChEMBL.	8126700
MIC (functional)	> 200 mg l-1	Tested in vitro for minimum inhibitory concentration against candida albicans 9	ChEMBL.	8126700
MIC (functional)	= 200 mg l-1	Tested in vitro for minimum inhibitory concentration against candida parapsilosis 39	ChEMBL.	8126700
MIC (functional)	> 200 mg l-1	Tested in vitro for minimum inhibitory concentration against candida albicans 124	ChEMBL.	8126700
MIC (functional)	> 200 mg l-1	Tested in vitro for minimum inhibitory concentration against candida albicans 9	ChEMBL.	8126700

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL154761
PubChem: 10266419

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 268101