Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | histone deacetylase 4 5 | 0.0054 | 0.0147 | 0.2285 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.0395 | 0.5832 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0083 | 0.0395 | 0.5832 |
Mycobacterium ulcerans | peptide deformylase | 0.1212 | 1 | 1 |
Brugia malayi | Histone deacetylase 1 | 0.0042 | 0.0046 | 0.0718 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0057 | 0.017 | 0.2636 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0042 | 0.0046 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.0395 | 0.5832 |
Brugia malayi | histone deacetylase 3 (HD3) | 0.0042 | 0.0046 | 0.0718 |
Echinococcus multilocularis | endothelin converting enzyme 1 | 0.0113 | 0.0645 | 1 |
Wolbachia endosymbiont of Brugia malayi | peptide deformylase | 0.1212 | 1 | 0.5 |
Schistosoma mansoni | neprilysin-2 (M13 family) | 0.0057 | 0.017 | 0.2636 |
Echinococcus granulosus | histone deacetylase | 0.0054 | 0.0147 | 0.1688 |
Trypanosoma brucei | histone deacetylase, putative | 0.0054 | 0.0147 | 0.0283 |
Trypanosoma brucei | histone deacetylase 3 | 0.0054 | 0.0147 | 0.0283 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0042 | 0.0046 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.0411 | 0.611 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0054 | 0.0147 | 0.0283 |
Mycobacterium leprae | PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) | 0.1212 | 1 | 1 |
Plasmodium falciparum | peptide deformylase | 0.1212 | 1 | 1 |
Plasmodium falciparum | histone deacetylase 2 | 0.0054 | 0.0147 | 0.0102 |
Plasmodium vivax | peptide deformylase, putative | 0.1212 | 1 | 1 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0054 | 0.0147 | 0.2285 |
Brugia malayi | Hypothetical zinc metalloproteinase T16A9.4 | 0.0113 | 0.0645 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.0411 | 0.611 |
Trypanosoma brucei | Peptide deformylase 2 | 0.0462 | 0.3622 | 1 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0462 | 0.3622 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0161 | 0.1942 |
Entamoeba histolytica | histone deacetylase, putative | 0.0042 | 0.0046 | 0.5 |
Loa Loa (eye worm) | histone deacetylase | 0.0054 | 0.0147 | 0.1711 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0042 | 0.0046 | 0.5 |
Loa Loa (eye worm) | histone deacetylase 7A | 0.0054 | 0.0147 | 0.1711 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.0645 | 1 |
Mycobacterium tuberculosis | Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) | 0.1212 | 1 | 1 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0094 | 0.049 | 0.7422 |
Schistosoma mansoni | Nep2 peptidase (M13 family) | 0.0057 | 0.017 | 0.2636 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0054 | 0.0147 | 0.1688 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0054 | 0.0147 | 0.0283 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0042 | 0.0046 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.0395 | 0.5832 |
Onchocerca volvulus | 0.0056 | 0.0161 | 0.9112 | |
Plasmodium falciparum | histone deacetylase, putative | 0.0054 | 0.0147 | 0.0102 |
Echinococcus granulosus | endothelin converting enzyme 1 | 0.0113 | 0.0645 | 1 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0042 | 0.0046 | 0.5 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0054 | 0.0147 | 0.0283 |
Brugia malayi | Matrixin family protein | 0.0063 | 0.0221 | 0.343 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0113 | 0.0645 | 1 |
Echinococcus granulosus | histone deacetylase 6 | 0.0054 | 0.0147 | 0.1688 |
Brugia malayi | histone deacetylase 1 (HD1) | 0.0042 | 0.0046 | 0.0718 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0462 | 0.3622 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.0411 | 0.611 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0462 | 0.3622 | 1 |
Brugia malayi | Peptidase family M13 containing protein | 0.0113 | 0.0645 | 1 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0057 | 0.017 | 0.2636 |
Brugia malayi | Histone deacetylase family protein | 0.0054 | 0.0147 | 0.2285 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.0645 | 1 |
Schistosoma mansoni | family M13 non-peptidase homologue (M13 family) | 0.0057 | 0.017 | 0.2636 |
Plasmodium vivax | histone deacetylase, putative | 0.0054 | 0.0147 | 0.0102 |
Toxoplasma gondii | histone deacetylase HDAC1 | 0.0054 | 0.0147 | 0.0102 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0042 | 0.0046 | 0.5 |
Echinococcus multilocularis | histone deacetylase | 0.0054 | 0.0147 | 0.1688 |
Loa Loa (eye worm) | matrixin family protein | 0.0063 | 0.0221 | 0.2941 |
Toxoplasma gondii | peptidase family M13 protein | 0.0113 | 0.0645 | 0.0601 |
Echinococcus granulosus | histone deacetylase 7 | 0.0054 | 0.0147 | 0.1688 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.0411 | 0.611 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0058 | 0.0177 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.0645 | 1 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0054 | 0.0147 | 0.1688 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0083 | 0.0395 | 0.5832 |
Treponema pallidum | polypeptide deformylase (def) | 0.1212 | 1 | 0.5 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0042 | 0.0046 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.1212 | 1 | 1 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0054 | 0.0147 | 0.2285 |
Echinococcus granulosus | histone deacetylase 6 | 0.0054 | 0.0147 | 0.1688 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.0042 | 0.0046 | 0.0027 |
Loa Loa (eye worm) | matrixin family protein | 0.0058 | 0.0177 | 0.2204 |
Echinococcus multilocularis | histone deacetylase 7 | 0.0054 | 0.0147 | 0.1688 |
Plasmodium vivax | histone deacetylase 2, putative | 0.0054 | 0.0147 | 0.0102 |
Leishmania major | polypeptide deformylase-like protein, putative | 0.0462 | 0.3622 | 1 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0094 | 0.049 | 0.7422 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.0042 | 0.0046 | 0.0027 |
Trypanosoma brucei | Polypeptide deformylase 1 | 0.0462 | 0.3622 | 1 |
Schistosoma mansoni | histone deacetylase | 0.0042 | 0.0046 | 0.0718 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.0411 | 0.611 |
Echinococcus granulosus | histone deacetylase 6 | 0.0054 | 0.0147 | 0.1688 |
Brugia malayi | Histone deacetylase family protein | 0.0054 | 0.0147 | 0.2285 |
Trypanosoma brucei | histone deacetylase 4 | 0.0054 | 0.0147 | 0.0283 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.0395 | 0.5832 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0046 | 0.0027 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0462 | 0.3622 | 1 |
Giardia lamblia | Histone deacetylase | 0.0042 | 0.0046 | 0.5 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0042 | 0.0046 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.0411 | 0.611 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0042 | 0.0046 | 0.5 |
Schistosoma mansoni | histone deacetylase | 0.0042 | 0.0046 | 0.0718 |
Leishmania major | histone deacetylase, putative | 0.0054 | 0.0147 | 0.0283 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0054 | 0.0147 | 0.1688 |
Onchocerca volvulus | Matrilysin homolog | 0.0058 | 0.0177 | 1 |
Leishmania major | histone deacetylase, putative | 0.0054 | 0.0147 | 0.0283 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | < 10 % | Tested for the inhibition of Candida GGTase I in Candida albicans at concentration of 3 microM | ChEMBL. | 11844687 |
Inhibition (binding) | < 10 % | Tested for the inhibition of Candida GGTase I in Candida albicans at concentration of 3 microM | ChEMBL. | 11844687 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.