Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.0932 | 1 |
Brugia malayi | Matrixin family protein | 0.0052 | 0.032 | 0.343 |
Onchocerca volvulus | 0.0046 | 0.0233 | 0.9112 | |
Brugia malayi | Hypothetical zinc metalloproteinase T16A9.4 | 0.0093 | 0.0932 | 1 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0267 | 0.3535 | 0.5 |
Mycobacterium leprae | PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) | 0.0699 | 1 | 1 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0047 | 0.0246 | 0.2636 |
Loa Loa (eye worm) | matrixin family protein | 0.0052 | 0.032 | 0.124 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0595 | 0.5172 |
Loa Loa (eye worm) | matrixin family protein | 0.0047 | 0.0256 | 0.0325 |
Schistosoma mansoni | family M13 non-peptidase homologue (M13 family) | 0.0047 | 0.0246 | 0.2636 |
Echinococcus granulosus | endothelin converting enzyme 1 | 0.0093 | 0.0932 | 1 |
Brugia malayi | Peptidase family M13 containing protein | 0.0093 | 0.0932 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0595 | 0.5172 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.0571 | 0.4828 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0047 | 0.0256 | 1 |
Plasmodium vivax | peptide deformylase, putative | 0.0699 | 1 | 0.5 |
Onchocerca volvulus | Matrilysin homolog | 0.0047 | 0.0256 | 1 |
Plasmodium falciparum | peptide deformylase | 0.0699 | 1 | 0.5 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0068 | 0.0571 | 0.4828 |
Toxoplasma gondii | hypothetical protein | 0.0699 | 1 | 1 |
Treponema pallidum | polypeptide deformylase (def) | 0.0699 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) | 0.0699 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | peptide deformylase | 0.0699 | 1 | 0.5 |
Schistosoma mansoni | neprilysin-2 (M13 family) | 0.0047 | 0.0246 | 0.2636 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0595 | 0.5172 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0093 | 0.0932 | 1 |
Trypanosoma brucei | Peptide deformylase 2 | 0.0267 | 0.3535 | 0.5 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0267 | 0.3535 | 0.5 |
Leishmania major | polypeptide deformylase-like protein, putative | 0.0267 | 0.3535 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0595 | 0.5172 |
Trypanosoma brucei | Polypeptide deformylase 1 | 0.0267 | 0.3535 | 0.5 |
Mycobacterium ulcerans | peptide deformylase | 0.0699 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0595 | 0.5172 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.0571 | 0.4828 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.0932 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.0571 | 0.4828 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0267 | 0.3535 | 0.5 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0068 | 0.0571 | 0.4828 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.0571 | 0.4828 |
Schistosoma mansoni | Nep2 peptidase (M13 family) | 0.0047 | 0.0246 | 0.2636 |
Echinococcus multilocularis | endothelin converting enzyme 1 | 0.0093 | 0.0932 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.0932 | 1 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0047 | 0.0246 | 0.2636 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0595 | 0.5172 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0267 | 0.3535 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Change (functional) | = -13 % | Percent change in the mean time to first Ouabain-induced arrhythmia was determined in Guinea pig at a dose of 10 mg/kg | ChEMBL. | 2299628 |
Delta APD95 (functional) | = 12 % | Duration of action potential was determined in vitro in Canine Purkinje fibers at 0.1 uM concentration. | ChEMBL. | 2299628 |
Delta APD95 (functional) | = 40 % | Duration of action potential of the compound in vitro against Canine Purkinje fibers; at 1 microM concentration | ChEMBL. | 2299628 |
Delta APD95 (functional) | = 46 % | Duration of action potential of the compound in vitro against Canine Purkinje fibers, at 10 uM concentration. | ChEMBL. | 2299628 |
Delta APD95 (functional) | = 52 % | Duration of action potential of the compound in vitro against Canine Purkinje fibers, at 30 uM concentration. | ChEMBL. | 2299628 |
Delta Vmax (ADMET) | = -15 % | Percent change from control value for Vmax at 30 uM of the compound. | ChEMBL. | 2299628 |
Delta Vmax (ADMET) | = -12 % | Percent change from control value for Vmax at 10 uM of the compound. | ChEMBL. | 2299628 |
Delta Vmax (ADMET) | = -4 % | Percent change from control value for Vmax at 0.1 uM of the compound. | ChEMBL. | 2299628 |
Delta Vmax (ADMET) | = -4 % | Percent change from control value for Vmax at 1 uM of the compound. | ChEMBL. | 2299628 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.