Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Chlamydia trachomatis | dihydrofolate reductase | 0.0415 | 0.0749 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0159 | 0.0033 | 0.5 |
Leishmania major | carbonic anhydrase family protein, putative | 0.0495 | 0.0972 | 0.0972 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase | 0.0954 | 0.2251 | 1 |
Mycobacterium tuberculosis | Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) | 0.0473 | 0.091 | 0.3374 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1195 | 0.2924 | 0.5 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.3732 | 1 | 1 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.3732 | 1 | 1 |
Mycobacterium ulcerans | carbonic anhydrase | 0.1195 | 0.2924 | 1 |
Leishmania major | C-8 sterol isomerase-like protein | 0.3732 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0415 | 0.0749 | 0.2578 |
Onchocerca volvulus | Putative sulfate transporter | 0.02 | 0.0149 | 0.5 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0415 | 0.0749 | 0.6965 |
Brugia malayi | Dihydrofolate reductase | 0.0415 | 0.0749 | 0.0749 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0159 | 0.0033 | 0.0033 |
Loa Loa (eye worm) | hypothetical protein | 0.3732 | 1 | 1 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.0495 | 0.0972 | 1 |
Brugia malayi | dihydrofolate reductase family protein | 0.0415 | 0.0749 | 0.0749 |
Schistosoma mansoni | dihydrofolate reductase | 0.0415 | 0.0749 | 0.7701 |
Loa Loa (eye worm) | hypothetical protein | 0.1908 | 0.4911 | 0.4911 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0415 | 0.0749 | 1 |
Schistosoma mansoni | carbonic anhydrase | 0.0495 | 0.0972 | 1 |
Onchocerca volvulus | 0.02 | 0.0149 | 0.5 | |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0159 | 0.0033 | 0.5 |
Echinococcus granulosus | dihydrofolate reductase | 0.0415 | 0.0749 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0159 | 0.0033 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0159 | 0.0033 | 0.0033 |
Entamoeba histolytica | carbonic anhydrase, putative | 0.0495 | 0.0972 | 0.5 |
Mycobacterium ulcerans | carbonic anhydrase | 0.0495 | 0.0972 | 0.1027 |
Mycobacterium tuberculosis | Probable conserved transmembrane protein | 0.0231 | 0.0236 | 0.0044 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0415 | 0.0749 | 0.0749 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0159 | 0.0033 | 0.0033 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.0254 | 0.0298 | 0.0353 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1195 | 0.2924 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
-Delta G (binding) | = 12.2 kCal mol-1 | Binding energy of the compound to Streptococcus faecium dihydrofolate reductase | ChEMBL. | 7120278 |
-Delta G (binding) | = 12.2 kCal mol-1 | Binding energy of the compound to Streptococcus faecium dihydrofolate reductase | ChEMBL. | 7120278 |
Delta G (binding) | = -12.2 kCal | Binding energy against Streptococcus faecium dihydrofolate reductase | ChEMBL. | 7392027 |
Delta G (binding) | = -12.2 kCal | Binding energy against Streptococcus faecium dihydrofolate reductase | ChEMBL. | 7392027 |
log(1/I50) (binding) | = 8.21 | Inhibition of Streptococcus faecium dihydrofolate reductase using dihydrofolate as substrate | ChEMBL. | 319234 |
log(1/I50) (binding) | = 8.76 | Inhibition of dihydrofolate reductase in mouse L1210R cells | ChEMBL. | 110930 |
log(1/I50) (binding) | = 8.94 | Inhibition of dihydrofolate reductase in human acute lymphocytic leukemia cells | ChEMBL. | 110930 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
3 literature references were collected for this gene.