Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | CMGC family protein kinase | 0.01 | 1 | 1 |
Chlamydia trachomatis | thymidylate kinase | 0.0087 | 0.8037 | 0.5 |
Toxoplasma gondii | cell-cycle-associated protein kinase GSK, putative | 0.01 | 1 | 1 |
Leishmania major | thymidylate kinase-like protein | 0.0087 | 0.8037 | 0.8037 |
Schistosoma mansoni | glycogen synthase kinase 3-related (gsk3) (cmgc group III) | 0.01 | 1 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.01 | 1 | 1 |
Trypanosoma brucei | protein kinase, putative | 0.01 | 1 | 1 |
Plasmodium falciparum | glycogen synthase kinase 3 | 0.01 | 1 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.01 | 1 | 1 |
Echinococcus multilocularis | glycogen synthase kinase 3 beta | 0.01 | 1 | 1 |
Trypanosoma cruzi | glycogen synthase kinase 3, putative | 0.01 | 1 | 1 |
Trypanosoma cruzi | thymidylate kinase, putative | 0.0087 | 0.8037 | 0.8037 |
Giardia lamblia | Kinase, CMGC GSK | 0.01 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | thymidylate kinase | 0.0087 | 0.8037 | 0.5 |
Echinococcus multilocularis | protein kinase shaggy | 0.01 | 1 | 1 |
Loa Loa (eye worm) | CMGC/GSK protein kinase | 0.01 | 1 | 1 |
Leishmania major | glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 | 0.01 | 1 | 1 |
Mycobacterium leprae | probable thymidylate kinase Tmk (dTMP KINASE) (THYMIDYLIC ACID KINASE) (TMPK) | 0.0087 | 0.8037 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.01 | 1 | 1 |
Mycobacterium tuberculosis | Thymidylate kinase Tmk (dTMP kinase) (thymidylic acid kinase) (TMPK) | 0.0087 | 0.8037 | 0.5 |
Echinococcus granulosus | protein kinase shaggy | 0.01 | 1 | 1 |
Mycobacterium ulcerans | thymidylate kinase | 0.0087 | 0.8037 | 0.5 |
Onchocerca volvulus | 0.01 | 1 | 1 | |
Loa Loa (eye worm) | CMGC/GSK protein kinase | 0.01 | 1 | 1 |
Trypanosoma cruzi | thymidylate kinase, putative | 0.0087 | 0.8037 | 0.8037 |
Treponema pallidum | thymidylate kinase (tmk) | 0.0087 | 0.8037 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.01 | 1 | 1 |
Plasmodium vivax | glycogen synthase kinase 3, putative | 0.01 | 1 | 1 |
Echinococcus granulosus | glycogen synthase kinase 3 beta | 0.01 | 1 | 1 |
Giardia lamblia | Kinase, CMGC GSK | 0.01 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 8.6 uM | Antiviral activity against HIV I strain (LAV) in human peripheral blood mononuclear (PBM) cells | ChEMBL. | 2918508 |
IC50 (ADMET) | > 100 uM | Cytotoxic effect in uninfected human peripheral blood mononuclear (PBM) cells | ChEMBL. | 2918508 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.