Detailed information for compound 271485

Basic information

Technical information
  • TDR Targets ID: 271485
  • Name: N-ethyl-5,5-dimethyl-N-(naphthalen-1-ylmethyl )hex-3-yn-1-amine
  • MW: 293.446 | Formula: C21H27N
  • H donors: 0 H acceptors: 0 LogP: 5.77 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(Cc1cccc2c1cccc2)CCC#CC(C)(C)C
  • InChi: 1S/C21H27N/c1-5-22(16-9-8-15-21(2,3)4)17-19-13-10-12-18-11-6-7-14-20(18)19/h6-7,10-14H,5,9,16-17H2,1-4H3
  • InChiKey: YDVYBDQVROJWGB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-ethyl-5,5-dimethyl-N-(1-naphthylmethyl)hex-3-yn-1-amine
  • N-ethyl-5,5-dimethyl-N-(1-naphthalenylmethyl)-3-hexyn-1-amine
  • 5,5-dimethylhex-3-ynyl-ethyl-(1-naphthylmethyl)amine
  • 105418-57-3

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica cysteine proteinase, putative 0.0027 0.0029 0.0896
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0078 0.0454 0.1043
Toxoplasma gondii PAN domain-containing protein 0.0035 0.0093 0.0007
Plasmodium falciparum cysteine repeat modular protein 1 0.0061 0.0311 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.004 0.0134 0.0814
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0033 0.0072 0.0165
Brugia malayi Cathepsin L-like precursor 0.0027 0.0029 0.0086
Plasmodium falciparum cysteine proteinase falcipain 3 0.0035 0.0091 0.2936
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0035 0.0091 0.2936
Trypanosoma cruzi cysteine peptidase, putative 0.0035 0.0091 0.0271
Echinococcus granulosus tyrosine protein kinase Fyn 0.0078 0.0454 0.1043
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.006 0.0305 0.0699
Loa Loa (eye worm) PAN domain-containing protein 0.0035 0.0093 0.0191
Brugia malayi PAN domain containing protein 0.0035 0.0093 0.0276
Echinococcus multilocularis tyrosine protein kinase Blk 0.007 0.039 0.0895
Loa Loa (eye worm) glutaminase 0.0219 0.1651 0.4848
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0073 0.0444
Onchocerca volvulus 0.0035 0.0093 0.0866
Loa Loa (eye worm) hypothetical protein 0.0066 0.0358 0.0982
Echinococcus granulosus cathepsin b 0.0423 0.3376 0.7744
Loa Loa (eye worm) ctsf protein 0.0035 0.0091 0.0186
Echinococcus granulosus neuroendocrine convertase 2 0.0106 0.0695 0.1595
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.0091 0.0553
Toxoplasma gondii microneme protein MIC4 0.0035 0.0093 0.0007
Leishmania major hypothetical protein, conserved 0.0061 0.0311 0.2417
Loa Loa (eye worm) TK protein kinase 0.007 0.039 0.1079
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0115 0.0768 0.0768
Echinococcus granulosus cathepsin L cysteine proteinase 0.0035 0.0091 0.021
Trypanosoma cruzi cysteine peptidase, putative 0.0035 0.0091 0.0271
Loa Loa (eye worm) hypothetical protein 0.0035 0.0093 0.0191
Echinococcus granulosus tyrosine protein kinase Src42A 0.0078 0.0454 0.1043
Entamoeba histolytica protein kinase, putative 0.0062 0.0325 1
Echinococcus multilocularis cathepsin b 0.0423 0.3376 0.7744
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0073 0.0444
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0142 0.1001 0.6061
Trypanosoma brucei cysteine peptidase C (CPC) 0.0142 0.1001 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0033 0.0072 0.0165
Toxoplasma gondii PAN domain-containing protein 0.0035 0.0093 0.0007
Onchocerca volvulus 0.0035 0.0093 0.0866
Toxoplasma gondii MAPEG family protein 0.0276 0.2135 0.8291
Schistosoma mansoni tyrosine kinase 0.0078 0.0454 0.0454
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.004 0.0134 0.0814
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0033 0.0072 0.0165
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0091 0.0553
Onchocerca volvulus 0.0035 0.0093 0.0866
Echinococcus granulosus calpain A 0.006 0.0305 0.0699
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0035 0.0091 0.0913
Loa Loa (eye worm) hypothetical protein 0.0423 0.3376 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0035 0.0091 0.021
Schistosoma mansoni cathepsin F (C01 family) 0.0035 0.0091 0.0091
Onchocerca volvulus 0.0035 0.0093 0.0866
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0091 0.0553
Trypanosoma cruzi cysteine peptidase, putative 0.0035 0.0091 0.0271
Echinococcus granulosus tyrosine protein kinase Src64B 0.0078 0.0454 0.1043
Onchocerca volvulus Cathepsin L homolog 0.0035 0.0091 0.0844
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.0033 0.0073 0.0444
Loa Loa (eye worm) hypothetical protein 0.0061 0.0311 0.0843
Loa Loa (eye worm) hypothetical protein 0.0036 0.0099 0.021
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0423 0.3376 0.3376
Loa Loa (eye worm) fibroinase 0.0035 0.0091 0.0186
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0423 0.3376 0.3376
Brugia malayi PAN domain containing protein 0.0035 0.0093 0.0276
Echinococcus multilocularis Furin 1 0.004 0.0134 0.0308
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0078 0.0454 0.1043
Loa Loa (eye worm) hypothetical protein 0.0035 0.0093 0.0191
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0078 0.0454 0.1043
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.0091 0.0553
Loa Loa (eye worm) cysteine protease 0.0035 0.0091 0.0186
Loa Loa (eye worm) glutaminase 2 0.0219 0.1651 0.4848
Brugia malayi Cathepsin L-like precursor 0.0035 0.0091 0.0271
Brugia malayi Cathepsin L-like cysteine proteinase 0.0027 0.0029 0.0086
Loa Loa (eye worm) calpain family protein 1 0.0057 0.0283 0.0758
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0423 0.3376 1
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0073 0.0444
Loa Loa (eye worm) SRC-1 0.0078 0.0454 0.1271
Onchocerca volvulus 0.0061 0.0311 0.3821
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0103 0.0666 0.1528
Brugia malayi PAN domain containing protein 0.0035 0.0093 0.0276
Echinococcus granulosus tyrosine protein kinase HCK 0.0062 0.0325 0.0745
Loa Loa (eye worm) hypothetical protein 0.0169 0.1227 0.3579
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0035 0.0091 0.0186
Echinococcus multilocularis neuroendocrine convertase 2 0.0106 0.0695 0.1595
Onchocerca volvulus Cathepsin F homolog 0.0035 0.0091 0.0844
Echinococcus multilocularis tyrosine protein kinase Srms 0.007 0.039 0.0895
Echinococcus granulosus tyrosine protein kinase Lyn 0.0078 0.0454 0.1043
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.0091 0.0553
Toxoplasma gondii microneme protein MIC17B 0.0035 0.0093 0.0007
Echinococcus granulosus microsomal glutathione S transferase 3 0.0276 0.2135 0.4897
Onchocerca volvulus 0.0035 0.0091 0.0844
Brugia malayi Cathepsin L-like precursor 0.0035 0.0091 0.0271
Trypanosoma cruzi cruzipain precursor, putative 0.0035 0.0091 0.0271
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.0091 0.0553
Loa Loa (eye worm) PAN domain-containing protein 0.0035 0.0093 0.0191
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0078 0.0454 0.1043
Loa Loa (eye worm) TK/ROR protein kinase 0.0063 0.033 0.0898
Toxoplasma gondii microneme protein, putative 0.0035 0.0093 0.0007
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0142 0.1001 0.2965
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0103 0.0666 0.4032
Toxoplasma gondii PAN/Apple domain-containing protein 0.0035 0.0093 0.0007
Echinococcus granulosus cathepsin l1 0.0035 0.0091 0.021
Giardia lamblia Cathepsin B precursor 0.0142 0.1001 1
Brugia malayi SRC-1 0.0078 0.0454 0.1346
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0061 0.0311 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0115 0.0768 0.0768
Echinococcus granulosus tyrosine protein kinase Fyn 0.0078 0.0454 0.1043
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.0033 0.0073 0.0444
Toxoplasma gondii microneme protein MIC17C 0.0035 0.0093 0.0007
Echinococcus granulosus tissue type plasminogen activator 0.0061 0.0311 0.0714
Schistosoma mansoni tyrosine kinase 0.0078 0.0454 0.0454
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0033 0.0072 0.0129
Loa Loa (eye worm) hypothetical protein 0.0051 0.0228 0.0593
Echinococcus multilocularis calpain family protein 1, d 0.0042 0.0155 0.0355
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0035 0.0091 0.0913
Brugia malayi Kringle domain containing protein 0.0061 0.0311 0.0922
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0091 0.0553
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0078 0.0454 0.1043
Brugia malayi PAN domain containing protein 0.0035 0.0093 0.0276
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0091 0.0553
Echinococcus granulosus tyrosine protein kinase Fyn 0.0078 0.0454 0.1043
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0029 0.0176
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0073 0.0444
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0035 0.0091 0.0913
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0073 0.0444
Echinococcus multilocularis cysteine protease 0.0035 0.0091 0.021
Loa Loa (eye worm) endoprotease bli-4 0.0169 0.1227 0.3579
Echinococcus multilocularis cysteine protease 0.0035 0.0091 0.021
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0035 0.0091 0.0913
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0073 0.0444
Loa Loa (eye worm) proprotein convertase 2 0.004 0.0134 0.0315
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.004 0.0134 0.0814
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0035 0.0091 0.0553
Toxoplasma gondii hypothetical protein 0.0035 0.0093 0.0007
Brugia malayi celfurPC protein 0.0136 0.095 0.2815
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.006 0.0305 0.0305
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0078 0.0454 0.1043
Schistosoma mansoni hypothetical protein 0.0061 0.0311 0.0311
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0103 0.0666 0.4032
Toxoplasma gondii cathepsin B 0.0142 0.1001 0.3691
Toxoplasma gondii PAN domain-containing protein 0.0326 0.2556 1
Brugia malayi Protein kinase domain containing protein 0.0063 0.033 0.0977
Onchocerca volvulus 0.0035 0.0093 0.0866
Onchocerca volvulus 0.0035 0.0091 0.0844
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.0033 0.0073 0.0444
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0035 0.0091 0.0913
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0035 0.0091 0.0913
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0033 0.0072 0.0072
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.0091 0.0553
Onchocerca volvulus 0.0035 0.0091 0.0844
Loa Loa (eye worm) hypothetical protein 0.0035 0.0093 0.0191
Loa Loa (eye worm) hypothetical protein 0.0035 0.0093 0.0191
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.004 0.0134 0.0814
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0073 0.0444
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0091 0.0553
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0091 0.0553
Schistosoma mansoni hypothetical protein 0.0033 0.0073 0.0073
Echinococcus granulosus tm gpcr rhodopsin 0.0539 0.4359 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0035 0.0091 0.0913
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0078 0.0454 0.1043
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0539 0.4359 1
Echinococcus granulosus tyrosine protein kinase Blk 0.007 0.039 0.0895
Loa Loa (eye worm) hypothetical protein 0.0035 0.0093 0.0191
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0035 0.0091 0.021
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.0091 0.0553
Plasmodium vivax vivapain-2 0.0035 0.0091 0.2936
Brugia malayi endoprotease bli-4 precursor 0.0169 0.1227 0.3635
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0035 0.0091 0.0913
Echinococcus granulosus tyrosine kinase 0.007 0.039 0.0895
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0103 0.0666 0.1528
Schistosoma mansoni microsomal glutathione s-transferase 0.0276 0.2135 0.2135
Loa Loa (eye worm) PAN domain-containing protein 0.0035 0.0093 0.0191
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0035 0.0091 0.0186
Brugia malayi PAN domain containing protein 0.0035 0.0093 0.0276
Echinococcus granulosus Furin 1 0.004 0.0134 0.0308
Schistosoma mansoni furin-1 (S08 family) 0.0074 0.0419 0.0419
Brugia malayi calpain family protein 1 0.0057 0.0283 0.0838
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0035 0.0091 0.0913
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.004 0.0134 0.0134
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0091 0.0553
Echinococcus granulosus cathepsin b 0.0423 0.3376 0.7744
Onchocerca volvulus 0.0035 0.0093 0.0866
Entamoeba histolytica cysteine protease, putative 0.0035 0.0091 0.2816
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.0091 0.0553
Brugia malayi PAN domain containing protein 0.0035 0.0093 0.0276
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0035 0.0091 0.021
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0057 0.0283 0.0283
Onchocerca volvulus 0.0035 0.0091 0.0844
Onchocerca volvulus 0.0035 0.0093 0.0866
Loa Loa (eye worm) hypothetical protein 0.0035 0.0093 0.0191
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0033 0.0072 0.0214
Toxoplasma gondii microneme protein MIC17A 0.0035 0.0093 0.0007
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0078 0.0454 0.1043
Brugia malayi protein-tyrosine kinase 0.007 0.039 0.1156
Loa Loa (eye worm) hypothetical protein 0.0035 0.0091 0.0186
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0091 0.0553
Entamoeba histolytica cysteine proteinase, putative 0.0035 0.0091 0.2816
Loa Loa (eye worm) PAN domain-containing protein 0.0035 0.0093 0.0191
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0035 0.0091 0.0913
Schistosoma mansoni glutaminase 0.0219 0.1651 0.1651
Schistosoma mansoni cathepsin F (C01 family) 0.0027 0.0029 0.0029
Echinococcus multilocularis 0.0136 0.095 0.218
Echinococcus multilocularis calpain A 0.006 0.0305 0.0699
Brugia malayi proprotein convertase 2 0.0106 0.0695 0.206
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0068 0.0372 0.0853
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0423 0.3376 0.3376
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.004 0.0134 0.0814
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0033 0.0072 0.0072
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0091 0.0553
Trichomonas vaginalis glutaminase, putative 0.0219 0.1651 1
Toxoplasma gondii kringle domain-containing protein 0.0061 0.0311 0.0892
Onchocerca volvulus 0.0035 0.0091 0.0844
Brugia malayi cathepsin B-like cysteine proteinase 0.0423 0.3376 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0035 0.0091 0.0553
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0142 0.1001 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.0091 0.0553
Toxoplasma gondii PAN domain-containing protein 0.0035 0.0093 0.0007
Entamoeba histolytica cysteine proteinase, putative 0.0035 0.0091 0.2816
Toxoplasma gondii hypothetical protein 0.0035 0.0093 0.0007
Brugia malayi Cathepsin L-like precursor 0.0035 0.0091 0.0271
Trichomonas vaginalis hypothetical protein 0.0033 0.0073 0.0444
Brugia malayi Cathepsin L-like precursor 0.0035 0.0091 0.0271
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0091 0.0553
Brugia malayi Cathepsin L-like precursor 0.0027 0.0029 0.0086
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0073 0.0444
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0027 0.0029 0.0086
Brugia malayi Trypsin family protein 0.0115 0.0768 0.2274
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0091 0.0553
Loa Loa (eye worm) hypothetical protein 0.0115 0.0768 0.2207
Brugia malayi PAN domain containing protein 0.0035 0.0093 0.0276
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0078 0.0454 0.1043
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.006 0.0305 0.0699
Trypanosoma cruzi hypothetical protein, conserved 0.0061 0.0311 0.0922
Onchocerca volvulus 0.0035 0.0093 0.0866
Echinococcus multilocularis tyrosine protein kinase HCK 0.0062 0.0325 0.0745
Schistosoma mansoni cathepsin F (C01 family) 0.0035 0.0091 0.0091
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.004 0.0134 0.0814
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0073 0.0444
Trypanosoma cruzi cysteine peptidase, putative 0.0035 0.0091 0.0271
Loa Loa (eye worm) cathepsin B 0.0142 0.1001 0.2904
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0091 0.0553
Toxoplasma gondii subtilisin SUB12 0.0042 0.0154 0.0255
Echinococcus granulosus furin 0.0169 0.1227 0.2815
Plasmodium vivax vivapain-2 0.0035 0.0091 0.2936
Brugia malayi Cathepsin L-like precursor 0.0035 0.0091 0.0271
Echinococcus granulosus cathepsin l1 0.0027 0.0029 0.0067
Loa Loa (eye worm) hypothetical protein 0.0035 0.0093 0.0191
Onchocerca volvulus 0.0093 0.0583 0.7494
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0142 0.1001 0.1001
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0078 0.0454 0.1043
Echinococcus granulosus tyrosine protein kinase Src42A 0.0068 0.0372 0.0853
Echinococcus granulosus cathepsin l cysteine peptidase 0.0035 0.0091 0.021
Brugia malayi Papain family cysteine protease containing protein 0.0035 0.0091 0.0271
Brugia malayi PAN domain containing protein 0.0035 0.0093 0.0276
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0091 0.0553
Onchocerca volvulus 0.0035 0.0093 0.0866
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0035 0.0091 0.0913
Loa Loa (eye worm) hypothetical protein 0.0057 0.0283 0.0758
Brugia malayi neuroendocrine convertase 1 precursor 0.0106 0.0695 0.206
Brugia malayi PAN domain containing protein 0.0035 0.0093 0.0276
Echinococcus multilocularis microsomal glutathione S transferase 3 0.0276 0.2135 0.4897
Mycobacterium ulcerans glutaminase 0.0219 0.1651 0.5
Echinococcus multilocularis tissue type plasminogen activator 0.0061 0.0311 0.0714
Loa Loa (eye worm) TK protein kinase 0.0062 0.0325 0.0883
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0169 0.1227 0.1227
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0033 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0115 0.0768 0.2207
Giardia lamblia Cathepsin B precursor 0.0142 0.1001 1
Brugia malayi calpain family protein 1 0.0057 0.0283 0.0838
Toxoplasma gondii PAN domain-containing protein 0.0035 0.0093 0.0007
Brugia malayi cathepsin L-like precursor 0.0027 0.0029 0.0086
Echinococcus multilocularis cathepsin b 0.0423 0.3376 0.7744
Onchocerca volvulus 0.0036 0.0099 0.0952
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0035 0.0091 0.0553
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0423 0.3376 0.3376
Brugia malayi glutaminase DH11.1 0.0219 0.1651 0.4892
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0035 0.0093 0.0007
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0035 0.0091 0.2936
Loa Loa (eye worm) PAN domain-containing protein 0.0035 0.0093 0.0191
Brugia malayi Cathepsin L-like precursor 0.0035 0.0091 0.0271
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0073 0.0444
Loa Loa (eye worm) calpain family protein 1 0.0042 0.0155 0.0375
Brugia malayi PAN domain containing protein 0.0035 0.0093 0.0276
Toxoplasma gondii PAN domain-containing protein 0.0326 0.2556 1
Giardia lamblia Cathepsin B precursor 0.0142 0.1001 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0033 0.0072 0.0165
Onchocerca volvulus Cathepsin L homolog 0.0035 0.0091 0.0844
Onchocerca volvulus 0.0035 0.0091 0.0844
Onchocerca volvulus 0.0035 0.0093 0.0866
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0029 0.0176
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0035 0.0091 0.0553
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.007 0.039 0.0895
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.006 0.0305 0.0305
Loa Loa (eye worm) hypothetical protein 0.0042 0.0155 0.0375
Echinococcus multilocularis tyrosine protein kinase Fyn 0.007 0.039 0.0895
Onchocerca volvulus 0.0035 0.0091 0.0844
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0078 0.0454 0.1043
Onchocerca volvulus 0.0035 0.0093 0.0866
Echinococcus multilocularis cathepsin L cysteine protease 0.0035 0.0091 0.021
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0073 0.0444
Giardia lamblia High cysteine membrane protein Group 2 0.0063 0.0328 0.2747
Onchocerca volvulus 0.0115 0.0768 1

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) = 0.02 mg l-1 Tested in vitro for minimum inhibitory concentration against microsporum canis ChEMBL. 8126700
MIC (functional) = 0.05 mg l-1 Tested in vitro for minimum inhibitory concentration against trichophyton mentagrophytes ChEMBL. 8126700
MIC (functional) = 0.2 mg l-1 Tested in vitro for minimum inhibitory concentration against Aspergillus fumigatus ChEMBL. 8126700
MIC (functional) = 3.13 mg l-1 Tested in vitro for minimum inhibitory concentration against candida parapsilosis 39 ChEMBL. 8126700
MIC (functional) = 12.5 mg l-1 Tested in vitro for minimum inhibitory concentration against sporothrix schenck ii ChEMBL. 8126700
MIC (functional) = 50 mg l-1 Tested in vitro for minimum inhibitory concentration against candida albicans 9 ChEMBL. 8126700
MIC (functional) = 50 mg l-1 Tested in vitro for minimum inhibitory concentration against candida albicans 9 ChEMBL. 8126700
MIC (functional) = 200 mg l-1 Tested in vitro for minimum inhibitory concentration against candida albicans 124 ChEMBL. 8126700
MIC (functional) = 200 mg l-1 Tested in vitro for minimum inhibitory concentration against candida albicans 124 ChEMBL. 8126700

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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