TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 890.107 | Formula: C48H75NO14
H donors: 3 H acceptors: 8 LogP: 4.92 Rotable bonds: 10
Rule of 5 violations (Lipinski): 2
SMILES: CCOC(=O)/C(=C/C[C@@H]1/C=C(\C)/C[C@H](C)C[C@H](OC)[C@H]2O[C@](O)([C@@H](C[C@@H]2OC)C)C(=O)C(=O)N2[C@H](C(=O)O[C@@H]([C@@H]([C@H](CC1=O)O)C)/C(=C/[C@@H]1CC[C@H]([C@@H](C1)OC)O)/C)CCCC2)/C
InChi: 1S/C48H75NO14/c1-11-61-46(55)29(4)15-17-34-21-27(2)20-28(3)22-40(59-9)43-41(60-10)24-31(6)48(57,63-43)44(53)45(54)49-19-13-12-14-35(49)47(56)62-42(32(7)37(51)26-38(34)52)30(5)23-33-16-18-36(50)39(25-33)58-8/h15,21,23,28,31-37,39-43,50-51,57H,11-14,16-20,22,24-26H2,1-10H3/b27-21+,29-15+,30-23+/t28-,31+,32+,33-,34+,35-,36+,37-,39+,40-,41-,42+,43+,48+/m0/s1
InChiKey: FHTUGPWEXLBGCZ-UIJNDAPBSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium vivax	kinesin-5	0.0025	0.0123	0.0279
Brugia malayi	neuropeptide F receptor	0.0012	0.0043	0.005
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0012	0.0043	0.0062
Echinococcus granulosus	heat shock protein 90	0.0013	0.0049	0.007
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0094	0.0751
Schistosoma mansoni	hypothetical protein	0.0021	0.0094	0.0134
Plasmodium falciparum	heat shock protein 90	0.0013	0.0049	0.012
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0075	0.0433	0.0619
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0075	0.0433	0.0619
Trypanosoma cruzi	PAB1-binding protein , putative	0.0032	0.0166	0.0564
Schistosoma mansoni	hypothetical protein	0.0012	0.0043	0.0062
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0075	0.0433	0.0619
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0012	0.0043	0.0312
Schistosoma mansoni	cpg binding protein	0.0019	0.0086	0.0123
Echinococcus multilocularis	G protein coupled receptor 139	0.0012	0.0043	0.0062
Echinococcus granulosus	hypothetical protein	0.0012	0.0043	0.0062
Brugia malayi	hypothetical protein	0.0012	0.0043	0.005
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0012	0.0043	0.0062
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0012	0.0043	0.0062
Brugia malayi	larval opioid receptor	0.0012	0.0043	0.005
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0043	0.0312
Onchocerca volvulus		0.016	0.0965	0.0926
Brugia malayi	putative neuropeptide receptor	0.0012	0.0043	0.005
Toxoplasma gondii	kinesin motor domain-containing protein	0.0025	0.0123	0.0279
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0012	0.0043	0.0062
Schistosoma mansoni	amine GPCR	0.0012	0.0043	0.0062
Echinococcus multilocularis	dro:myosuppressin receptor	0.0012	0.0043	0.0062
Schistosoma mansoni	heat shock protein	0.0013	0.0049	0.007
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0012	0.0043	0.0062
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0043	0.0312
Brugia malayi	latrophilin 2 splice variant baaae	0.0021	0.0094	0.012
Leishmania major	heat shock protein 83-1	0.0013	0.0049	0.0064
Trypanosoma cruzi	heat shock protein 85, putative	0.0013	0.0049	0.0127
Schistosoma mansoni	myosin xvIII	0.0012	0.0043	0.0062
Echinococcus granulosus	GPCR family 2	0.001	0.0025	0.0035
Echinococcus multilocularis	g-protein coupled receptor	0.0012	0.0043	0.0062
Echinococcus granulosus	7TM GPCR rhodopsin	0.0012	0.0043	0.0062
Plasmodium falciparum	ataxin-2 like protein, putative	0.0032	0.0166	0.0557
Echinococcus granulosus	geminin	0.0102	0.0604	0.0864
Plasmodium vivax	telomerase reverse transcriptase, putative	0.044	0.2706	1
Giardia lamblia	Kinesin-5	0.0025	0.0123	0.0341
Echinococcus multilocularis	heat shock protein 90	0.0013	0.0049	0.007
Schistosoma mansoni	hypothetical protein	0.001	0.0025	0.0035
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0012	0.0043	0.0062
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0012	0.0043	0.0062
Leishmania major	heat shock protein 83-1	0.0013	0.0049	0.0064
Echinococcus granulosus	rhodopsin orphan GPCR	0.0012	0.0043	0.0062
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0075	0.0433	0.0619
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0012	0.0043	0.0062
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0043	0.0312
Echinococcus granulosus	ferritin	0.0006	0.0001	0.0001
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0012	0.0043	0.0062
Leishmania major	heat shock protein 83-1	0.0013	0.0049	0.0064
Leishmania major	heat shock protein 83-1	0.0013	0.0049	0.0064
Echinococcus multilocularis	fmrfamide receptor	0.0012	0.0043	0.0062
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0012	0.0043	0.0062
Schistosoma mansoni	amine GPCR	0.0012	0.0043	0.0062
Echinococcus granulosus	sex peptide receptor	0.0012	0.0043	0.0062
Brugia malayi	CXXC zinc finger family protein	0.0019	0.0086	0.0109
Echinococcus granulosus	neuropeptide FF receptor 2	0.0012	0.0043	0.0062
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0012	0.0043	0.005
Brugia malayi	hypothetical protein	0.0012	0.0043	0.005
Echinococcus granulosus	neuropeptide Y receptor	0.0012	0.0043	0.0062
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0012	0.0043	0.0312
Schistosoma mansoni	opsin-like receptor	0.0012	0.0043	0.0062
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0043	0.0312
Leishmania major	heat shock protein 83-1	0.0013	0.0049	0.0064
Schistosoma mansoni	apoferritin-2	0.0006	0.0001	0.0001
Schistosoma mansoni	adenoreceptor	0.0012	0.0043	0.0062
Schistosoma mansoni	hypothetical protein	0.001	0.0025	0.0035
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0012	0.0043	0.0062
Schistosoma mansoni	amine GPCR	0.0012	0.0043	0.0062
Brugia malayi	ORL1-like opioid receptor	0.0012	0.0043	0.005
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0043	0.0312
Echinococcus multilocularis	endoplasmin	0.0011	0.0032	0.0046
Echinococcus multilocularis	neuropeptide receptor	0.0012	0.0043	0.0062
Echinococcus granulosus	G protein coupled receptor 139	0.0012	0.0043	0.0062
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0043	0.0312
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0012	0.0043	0.0062
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0021	0.0094	0.0134
Brugia malayi	Telomerase reverse transcriptase	0.117	0.7259	1
Brugia malayi	Pre-SET motif family protein	0.0021	0.0094	0.012
Schistosoma mansoni	opsin-like receptor	0.0012	0.0043	0.0062
Echinococcus granulosus	tm gpcr rhodopsin	0.0012	0.0043	0.0062
Schistosoma mansoni	P2X receptor subunit	0.1126	0.6989	1
Brugia malayi	Latrophilin receptor protein 2	0.001	0.0025	0.0025
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0021	0.0094	0.0134
Plasmodium falciparum	ataxin-2 like protein, putative	0.0032	0.0166	0.0557
Echinococcus granulosus	heat shock protein heat shock protein 90 alpha	0.0011	0.0032	0.0046
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0012	0.0043	0.0062
Schistosoma mansoni	neuropeptide receptor	0.0012	0.0043	0.0062
Schistosoma mansoni	hypothetical protein	0.0169	0.1022	0.1462
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0012	0.0043	0.0062
Echinococcus granulosus	dro:myosuppressin receptor	0.0012	0.0043	0.0062
Brugia malayi	heat shock protein 90	0.0013	0.0049	0.0058
Echinococcus multilocularis	ferritin	0.0006	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0043	0.0312
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0043	0.0312
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0012	0.0043	0.0062
Trypanosoma brucei	telomerase reverse transcriptase	0.044	0.2706	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0012	0.0043	0.0312
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0043	0.0312
Plasmodium falciparum	kinesin-5	0.0025	0.0123	0.0396
Echinococcus granulosus	biogenic amine 5HT receptor	0.0012	0.0043	0.0062
Loa Loa (eye worm)	endoplasmin	0.0013	0.0049	0.0361
Trichomonas vaginalis	heat shock protein, putative	0.0011	0.0032	0.032
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0043	0.0312
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0012	0.0043	0.0062
Echinococcus multilocularis	neuropeptides capa receptor	0.0012	0.0043	0.0062
Loa Loa (eye worm)	latrophilin receptor protein 2	0.001	0.0025	0.0151
Schistosoma mansoni	endoplasmin	0.0013	0.0049	0.007
Schistosoma mansoni	opsin-like receptor	0.0012	0.0043	0.0062
Leishmania major	heat shock protein 83-1	0.0013	0.0049	0.0064
Echinococcus granulosus	rhodopsin orphan GPCR	0.0012	0.0043	0.0062
Schistosoma mansoni	neuropeptide f receptor 76f	0.0012	0.0043	0.0062
Echinococcus multilocularis	neuropeptide Y receptor	0.0012	0.0043	0.0062
Brugia malayi	hypothetical protein	0.0021	0.0095	0.0122
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0043	0.0312
Brugia malayi	Dopamine receptor protein 1	0.0012	0.0043	0.005
Leishmania major	hypothetical protein, conserved	0.0032	0.0166	0.0503
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0012	0.0043	0.005
Leishmania major	telomerase reverse transcriptase, putative	0.044	0.2706	1
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0019	0.0086	0.0686
Echinococcus multilocularis	orexin receptor type 2	0.0012	0.0043	0.0062
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0021	0.0094	0.0134
Echinococcus multilocularis	kinesin family 1	0.0195	0.1179	0.1688
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0012	0.0043	0.0062
Echinococcus multilocularis	geminin	0.0102	0.0604	0.0864
Schistosoma mansoni	hypothetical protein	0.0102	0.0604	0.0864
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0012	0.0043	0.0062
Echinococcus granulosus	p2X purinoceptor 4	0.1126	0.6989	1
Brugia malayi	hypothetical protein	0.0012	0.0043	0.005
Echinococcus granulosus	expressed protein	0.0006	0.0001	0.0001
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0021	0.0094	0.0134
Trypanosoma cruzi	PAB1-binding protein , putative	0.0032	0.0166	0.0564
Echinococcus granulosus	somatostatin receptor	0.0012	0.0043	0.0062
Brugia malayi	hypothetical protein	0.0012	0.0043	0.005
Loa Loa (eye worm)	hypothetical protein	0.003	0.0153	0.1268
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0043	0.0312
Echinococcus granulosus	rhodopsin orphan GPCR	0.0012	0.0043	0.0062
Onchocerca volvulus		0.0019	0.0086	0.0043
Echinococcus multilocularis	neuropeptide receptor A26	0.0012	0.0043	0.0062
Echinococcus multilocularis	heat shock protein	0.0013	0.0049	0.007
Leishmania major	heat shock protein 83-1	0.0013	0.0049	0.0064
Brugia malayi	putative neuropeptide receptor NPR1	0.0012	0.0043	0.005
Echinococcus granulosus	rhodopsin orphan GPCR	0.0012	0.0043	0.0062
Loa Loa (eye worm)	TYRA-2 protein	0.0012	0.0043	0.0312
Loa Loa (eye worm)	neuropeptide F receptor	0.0012	0.0043	0.0312
Trypanosoma cruzi	telomerase reverse transcriptase, putative	0.044	0.2706	1
Leishmania major	heat shock protein 83-1	0.0013	0.0049	0.0064
Entamoeba histolytica	kinesin, putative	0.0025	0.0123	1
Mycobacterium leprae	PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G)	0.0011	0.0032	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0012	0.0043	0.0062
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0012	0.0043	0.0062
Echinococcus granulosus	heat shock protein	0.0013	0.0049	0.007
Schistosoma mansoni	ferritin	0.0006	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0043	0.0312
Echinococcus granulosus	p2X purinoceptor 4	0.1126	0.6989	1
Brugia malayi	G-protein coupled receptor	0.0012	0.0043	0.005
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0012	0.0043	0.0062
Echinococcus granulosus	neuropeptides capa receptor	0.0012	0.0043	0.0062
Schistosoma mansoni	biogenic amine receptor	0.0012	0.0043	0.0062
Brugia malayi	RE15519p	0.0012	0.0043	0.005
Echinococcus multilocularis	allatostatin A receptor	0.0012	0.0043	0.0062
Brugia malayi	Calcitonin receptor-like protein seb-1	0.003	0.0153	0.0202
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0012	0.0043	0.0312
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0043	0.0312
Schistosoma mansoni	P2X receptor subunit	0.0622	0.3842	0.5498
Echinococcus granulosus	tm gpcr rhodopsin	0.0012	0.0043	0.0062
Brugia malayi	hypothetical protein	0.0012	0.0043	0.005
Echinococcus multilocularis	neuropeptide Y receptor	0.0012	0.0043	0.0062
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0043	0.0312
Trichomonas vaginalis	heat shock protein, putative	0.0011	0.0032	0.032
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0043	0.0312
Echinococcus granulosus	fmrfamide receptor	0.0012	0.0043	0.0062
Brugia malayi	Endoplasmin precursor	0.0013	0.0049	0.0058
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0012	0.0043	0.0062
Schistosoma mansoni	kinesin eg-5	0.0025	0.0123	0.0176
Treponema pallidum	heat shock protein 90	0.0011	0.0032	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0012	0.0043	0.0312
Echinococcus multilocularis	fmrfamide receptor	0.0012	0.0043	0.0062
Echinococcus multilocularis	muscleblind protein	0.0191	0.1157	0.1656
Trypanosoma cruzi	Heat shock protein 83, putative	0.0013	0.0049	0.0127
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.003	0.0153	0.0202
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0043	0.0312
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0043	0.0312
Echinococcus multilocularis	p2X purinoceptor 4	0.1126	0.6989	1
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0012	0.0043	0.0312
Trichomonas vaginalis	set domain proteins, putative	0.016	0.0965	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0043	0.0312
Schistosoma mansoni	ferritin	0.0006	0.0001	0.0001
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0012	0.0043	0.0062
Echinococcus granulosus	tm gpcr rhodopsin	0.0012	0.0043	0.0062
Schistosoma mansoni	hypothetical protein	0.0014	0.0056	0.0079
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0012	0.0043	0.0062
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0166	0.1383
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0012	0.0043	0.0062
Echinococcus granulosus	neuropeptide receptor A26	0.0012	0.0043	0.0062
Schistosoma mansoni	P2X receptor subunit	0.1126	0.6989	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0012	0.0043	0.0062
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0012	0.0043	0.0062
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.001	0.0025	0.0035
Schistosoma mansoni	endoplasmin	0.0013	0.0049	0.007
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0021	0.0094	0.0169
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0043	0.0312
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0012	0.0043	0.0062
Brugia malayi	GnHR receptor homolog	0.0012	0.0043	0.005
Brugia malayi	sulfakinin receptor protein	0.0012	0.0043	0.005
Brugia malayi	Kinesin motor domain containing protein	0.0025	0.0123	0.016
Schistosoma mansoni	neuropeptide receptor	0.0012	0.0043	0.0062
Echinococcus multilocularis	neuropeptide receptor	0.0012	0.0043	0.0062
Trypanosoma cruzi	telomerase reverse transcriptase, putative	0.044	0.2706	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0043	0.0312
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0043	0.0312
Onchocerca volvulus		0.0021	0.0094	0.0051
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.001	0.0025	0.0035
Echinococcus granulosus	histone lysine methyltransferase setb	0.0021	0.0094	0.0134
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0012	0.0043	0.0062
Plasmodium vivax	ataxin-2 like protein, putative	0.0032	0.0166	0.0442
Wolbachia endosymbiont of Brugia malayi	heat shock protein 90	0.0011	0.0032	1
Brugia malayi	G-protein coupled receptor	0.0012	0.0043	0.005
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0043	0.0312
Leishmania major	heat shock protein 83-1	0.0013	0.0049	0.0064
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0043	0.0312
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0014	0.0056	0.0079
Echinococcus granulosus	g protein coupled receptor	0.0012	0.0043	0.0062
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0012	0.0043	0.0062
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.001	0.0025	0.0025
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0012	0.0043	0.0062
Echinococcus multilocularis	g protein coupled receptor	0.0012	0.0043	0.0062
Schistosoma mansoni	biogenic amine receptor	0.0012	0.0043	0.0062
Echinococcus granulosus	g protein coupled receptor	0.0012	0.0043	0.0062
Trypanosoma cruzi	heat shock protein 85, putative	0.0013	0.0049	0.0127
Loa Loa (eye worm)	hypothetical protein	0.0191	0.1157	1
Brugia malayi	Pre-SET motif family protein	0.0141	0.0844	0.1155
Echinococcus granulosus	orexin receptor type 2	0.0012	0.0043	0.0062
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.001	0.0025	0.0035
Echinococcus multilocularis	somatostatin receptor	0.0012	0.0043	0.0062
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0012	0.0043	0.0062
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0007	0.0007	0.0011
Echinococcus granulosus	neuropeptide s receptor	0.0012	0.0043	0.0062
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.001	0.0025	0.0035
Echinococcus multilocularis	g protein coupled receptor	0.0012	0.0043	0.0062
Echinococcus granulosus	neuropeptide receptor	0.0012	0.0043	0.0062
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0012	0.0043	0.0062
Schistosoma mansoni	cpg binding protein	0.002	0.0093	0.0133
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0141	0.0844	0.728
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0094	0.0751
Loa Loa (eye worm)	G-protein coupled receptor	0.0012	0.0043	0.0312
Schistosoma mansoni	hypothetical protein	0.0012	0.0043	0.0062
Brugia malayi	hypothetical protein	0.0012	0.0043	0.005
Trypanosoma brucei	PAB1-binding protein , putative	0.0032	0.0166	0.0442
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0007	0.0007	0.0011
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0012	0.0043	0.0062
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0012	0.0043	0.0062
Leishmania major	heat shock protein 83-1	0.0013	0.0049	0.0064
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0012	0.0043	0.0062
Toxoplasma gondii	LsmAD domain-containing protein	0.0032	0.0166	0.0442
Giardia lamblia	Telomerase catalytic subunit	0.044	0.2706	1
Echinococcus multilocularis	serotonin receptor	0.0012	0.0043	0.0062
Echinococcus granulosus	serotonin receptor	0.0012	0.0043	0.0062
Trichomonas vaginalis	heat shock protein, putative	0.0011	0.0032	0.032
Echinococcus multilocularis	serotonin receptor	0.0012	0.0043	0.0062
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0043	0.0312
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0012	0.0043	0.005
Echinococcus multilocularis	g protein coupled receptor	0.0012	0.0043	0.0062
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0012	0.0043	0.0062
Echinococcus multilocularis	p2X purinoceptor 4	0.1126	0.6989	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0043	0.0312
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0012	0.0043	0.0062
Schistosoma mansoni	hypothetical protein	0.0012	0.0043	0.0062
Echinococcus multilocularis	p2X purinoceptor 4	0.1126	0.6989	1
Schistosoma mansoni	hypothetical protein	0.0012	0.0043	0.0062
Echinococcus granulosus	muscleblind protein	0.0191	0.1157	0.1656
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0075	0.0433	0.0587
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0014	0.0056	0.0079
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0075	0.0433	0.0619
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0043	0.0312
Leishmania major	heat shock protein 83-1	0.0013	0.0049	0.0064
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0012	0.0043	0.0062
Echinococcus granulosus	kinesin family 1	0.0195	0.1179	0.1688
Trichomonas vaginalis	heat shock protein, putative	0.0013	0.0049	0.0496
Loa Loa (eye worm)	hypothetical protein	0.001	0.0025	0.0151
Schistosoma mansoni	biogenic amine receptor	0.0012	0.0043	0.0062
Toxoplasma gondii	RNA-directed DNA polymerase	0.044	0.2706	1
Leishmania major	heat shock protein 83-1	0.0013	0.0049	0.0064
Brugia malayi	hypothetical protein	0.0012	0.0043	0.005
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0012	0.0043	0.0062
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0043	0.0312
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0043	0.0312
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0043	0.0312
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0012	0.0043	0.0062
Loa Loa (eye worm)	hypothetical protein	0.0191	0.1157	1
Echinococcus multilocularis	neuropeptides capa receptor	0.0012	0.0043	0.0062
Schistosoma mansoni	heat shock protein	0.0013	0.0049	0.007
Schistosoma mansoni	growth hormone secretagogue receptor	0.0012	0.0043	0.0062
Brugia malayi	Dopamine receptor	0.0012	0.0043	0.005
Schistosoma mansoni	cpg binding protein	0.002	0.0093	0.0133
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0043	0.0312
Brugia malayi	hypothetical protein	0.0012	0.0043	0.005
Echinococcus granulosus	g protein coupled receptor	0.0012	0.0043	0.0062
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0075	0.0433	0.0619
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0012	0.0043	0.005
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0043	0.0312
Schistosoma mansoni	neuropeptide receptor	0.0012	0.0043	0.0062
Echinococcus granulosus	rhodopsin orphan GPCR	0.0012	0.0043	0.0062
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0019	0.0086	0.0124
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0012	0.0043	0.0062
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0042	0.0226	0.0324
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.003	0.0153	0.1268
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0043	0.0312
Loa Loa (eye worm)	melatonin receptor type 1A	0.0012	0.0043	0.0312
Echinococcus multilocularis	cpg binding protein	0.002	0.0093	0.0133
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0043	0.0312
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0012	0.0043	0.0062
Trypanosoma cruzi	heat shock protein 90, putative	0.0013	0.0049	0.0127
Brugia malayi	Serotonin receptor	0.0012	0.0043	0.005
Trypanosoma cruzi	heat shock protein 85, putative	0.0011	0.0032	0.0064
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0012	0.0043	0.005
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0012	0.0043	0.0062
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0043	0.0312
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0012	0.0043	0.0062
Plasmodium falciparum	telomerase reverse transcriptase	0.044	0.2706	1
Leishmania major	heat shock protein 83-1	0.0013	0.0049	0.0064
Plasmodium vivax	SET domain protein, putative	0.0021	0.0094	0.0169
Trypanosoma cruzi	heat shock protein 85, putative	0.0013	0.0049	0.0127
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0043	0.0312
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0043	0.0312
Brugia malayi	neuropeptide F receptor	0.0012	0.0043	0.005
Brugia malayi	hypothetical protein	0.0012	0.0043	0.005
Schistosoma mansoni	amine GPCR	0.0012	0.0043	0.0062
Leishmania major	heat shock protein 83-1	0.0013	0.0049	0.0064
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0012	0.0043	0.0312
Mycobacterium tuberculosis	Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G)	0.0011	0.0032	1
Echinococcus multilocularis	expressed protein	0.0006	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0043	0.0312
Brugia malayi	AKH receptor	0.0012	0.0043	0.005
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0012	0.0043	0.0062
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0043	0.0312
Mycobacterium ulcerans	heat shock protein 90	0.0011	0.0032	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0043	0.0312
Echinococcus granulosus	heat shock protein 90	0.0011	0.0032	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0043	0.0312
Echinococcus multilocularis	heat shock protein 90	0.0011	0.0032	0.0046
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0012	0.0043	0.0062
Schistosoma mansoni	ferritin	0.0006	0.0001	0.0001
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0021	0.0094	0.0134
Echinococcus granulosus	allatostatin A receptor	0.0012	0.0043	0.0062
Echinococcus granulosus	rhodopsin orphan GPCR	0.0012	0.0043	0.0062
Loa Loa (eye worm)	kinesin-like protein KLP2	0.0025	0.0123	0.1006
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0012	0.0043	0.0062
Schistosoma mansoni	ferritin light chain	0.0006	0.0001	0.0001
Echinococcus granulosus	cpg binding protein	0.002	0.0093	0.0133
Schistosoma mansoni	P2X receptor subunit	0.0622	0.3842	0.5498
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0012	0.0043	0.0062
Trichomonas vaginalis	heat shock protein, putative	0.0008	0.0017	0.0161
Leishmania major	heat shock protein 83-1	0.0013	0.0049	0.0064
Schistosoma mansoni	amine GPCR	0.0012	0.0043	0.0062
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0012	0.0043	0.0062
Brugia malayi	Muscleblind-like protein	0.0191	0.1157	0.1586
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0075	0.0433	0.37
Leishmania major	heat shock protein 83-1	0.0013	0.0049	0.0064
Brugia malayi	hypothetical protein	0.0032	0.0166	0.022
Echinococcus multilocularis	muscleblind protein 1	0.0191	0.1157	0.1656
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0012	0.0043	0.0062
Echinococcus granulosus	neuropeptide receptor	0.0012	0.0043	0.0062
Echinococcus granulosus	rhodopsin orphan GPCR	0.0012	0.0043	0.0062
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0012	0.0043	0.0062
Schistosoma mansoni	hypothetical protein	0.001	0.0025	0.0035
Echinococcus multilocularis	GPCR, family 2	0.001	0.0025	0.0035
Echinococcus granulosus	7tm_1 domain containing protein	0.0012	0.0043	0.0062
Schistosoma mansoni	neuropeptide receptor	0.0012	0.0043	0.0062
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0043	0.0312
Echinococcus multilocularis	sex peptide receptor	0.0012	0.0043	0.0062
Echinococcus granulosus	p2X purinoceptor 4	0.1126	0.6989	1
Echinococcus granulosus	g-protein coupled receptor	0.0012	0.0043	0.0062
Brugia malayi	hypothetical protein	0.0012	0.0043	0.005
Echinococcus granulosus	neuropeptide Y receptor	0.0012	0.0043	0.0062
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0043	0.0312
Schistosoma mansoni	hypothetical protein	0.001	0.0025	0.0035
Brugia malayi	G protein-coupled receptor F59B2.13	0.0012	0.0043	0.005
Echinococcus granulosus	biogenic amine 5HT receptor	0.0012	0.0043	0.0062
Giardia lamblia	Heat shock protein HSP 90-alpha	0.0013	0.0049	0.0064
Schistosoma mansoni	neuropeptide F-like receptor	0.0012	0.0043	0.0062
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0043	0.0312
Schistosoma mansoni	hypothetical protein	0.0102	0.0604	0.0864
Trypanosoma cruzi	heat shock protein 90, putative	0.0011	0.0032	0.0064
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0012	0.0043	0.0062
Brugia malayi	G protein-coupled receptor	0.0012	0.0043	0.005
Brugia malayi	Melatonin receptor type 1A	0.0012	0.0043	0.005
Brugia malayi	Serotonin receptor	0.0012	0.0043	0.005
Schistosoma mansoni	ferritin light chain	0.0006	0.0001	0.0001
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0012	0.0043	0.0062
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0012	0.0043	0.0062
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0012	0.0043	0.005
Echinococcus multilocularis	neuropeptide s receptor	0.0012	0.0043	0.0062
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0021	0.0094	0.0134
Leishmania major	heat shock protein 83-1	0.0013	0.0049	0.0064
Schistosoma mansoni	apoferritin-2	0.0006	0.0001	0.0001
Schistosoma mansoni	ferritin	0.0006	0.0001	0.0001
Loa Loa (eye worm)	heat shock protein 90	0.0013	0.0049	0.0361
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0012	0.0043	0.0062
Echinococcus granulosus	endoplasmin	0.0011	0.0032	0.0046
Brugia malayi	follicle stimulating hormone receptor	0.0012	0.0043	0.005
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0043	0.0312
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0075	0.0433	0.0619
Echinococcus granulosus	neuropeptides capa receptor	0.0012	0.0043	0.0062
Trichomonas vaginalis	endoplasmin, putative	0.0008	0.0017	0.0161
Schistosoma mansoni	neuropeptide F-like receptor	0.0012	0.0043	0.0062
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0037	0.0199	0.0565
Schistosoma mansoni	histamine h1 receptor	0.0012	0.0043	0.0062
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0012	0.0043	0.0062
Brugia malayi	Dopamine receptor protein 2	0.0012	0.0043	0.005
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0012	0.0043	0.0062

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (functional)	= 228 nM	Concentration required to reverse inhibition of T-cell proliferation, by measuring [3H]-thymidine uptake up to a concentration of 10 uM (Antagonistic activity, immunosuppression)	ChEMBL.	No reference
IC50 (functional)	= 10000 nM	Agonistic activity in a murine splenic T-cell proliferation assay was calculated by measurement of [3H]-thymidine uptake relative to control	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

No literature references available for this target.

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Detailed information for compound 272247