Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | kelch ECH associated protein 1 | 0.0232 | 0.4854 | 0.4854 |
Echinococcus granulosus | kelch protein 12 | 0.0001 | 0.0001 | 0.0001 |
Brugia malayi | Kelch-like protein X | 0.0001 | 0.0001 | 0.0001 |
Onchocerca volvulus | 0.0001 | 0 | 0.5 | |
Echinococcus granulosus | kelch protein 3 | 0.0001 | 0.0001 | 0.0001 |
Loa Loa (eye worm) | Klhl5 protein | 0.0001 | 0.0001 | 1 |
Brugia malayi | BTB/POZ domain containing protein | 0.0001 | 0.0001 | 0.0001 |
Echinococcus granulosus | kelch ECH associated protein 1 | 0.0232 | 0.4854 | 0.4854 |
Schistosoma mansoni | hypothetical protein | 0.0001 | 0.0001 | 0.0001 |
Schistosoma mansoni | hypothetical protein | 0.0001 | 0.0001 | 0.0001 |
Echinococcus multilocularis | ectoderm neural cortex protein 1 | 0.0001 | 0.0001 | 0.0001 |
Entamoeba histolytica | hypothetical protein | 0.0476 | 1 | 0.5 |
Onchocerca volvulus | 0.0001 | 0 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.0001 | 0.0001 | 0.0001 |
Echinococcus multilocularis | Kelch repeat type 1 | 0.0232 | 0.4868 | 0.4868 |
Echinococcus multilocularis | kelch protein 12 | 0.0001 | 0.0001 | 0.0001 |
Schistosoma mansoni | hypothetical protein | 0.0232 | 0.4868 | 0.4868 |
Echinococcus granulosus | kelch ECH associated protein 1 like | 0.0232 | 0.4854 | 0.4854 |
Echinococcus granulosus | kelch ECH associated protein 1 like | 0.0232 | 0.4854 | 0.4854 |
Brugia malayi | Kelch motif family protein | 0.0001 | 0.0001 | 0.0001 |
Echinococcus granulosus | kelch protein 18 | 0.0001 | 0.0001 | 0.0001 |
Onchocerca volvulus | 0.0001 | 0 | 0.5 | |
Entamoeba histolytica | hypothetical protein | 0.0476 | 1 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0476 | 1 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0476 | 1 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0476 | 1 | 1 |
Brugia malayi | Kelch motif family protein | 0.0001 | 0.0001 | 0.0001 |
Schistosoma mansoni | hypothetical protein | 0.0476 | 1 | 1 |
Echinococcus granulosus | kelch protein 10 | 0.0001 | 0.0001 | 0.0001 |
Loa Loa (eye worm) | ring canal kelch protein | 0.0001 | 0.0001 | 1 |
Onchocerca volvulus | 0.0001 | 0 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.0001 | 0.0001 | 0.0001 |
Echinococcus multilocularis | kelch protein 3 | 0.0001 | 0.0001 | 0.0001 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0476 | 1 | 1 |
Echinococcus granulosus | ectoderm neural cortex protein 1 | 0.0001 | 0.0001 | 0.0001 |
Schistosoma mansoni | hypothetical protein | 0.0001 | 0.0001 | 0.0001 |
Echinococcus multilocularis | kelch protein 10 | 0.0001 | 0.0001 | 0.0001 |
Schistosoma mansoni | hypothetical protein | 0.0001 | 0.0001 | 0.0001 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0476 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0001 | 0.0001 | 0.0001 |
Loa Loa (eye worm) | kelch domain-containing protein family protein | 0.0001 | 0.0001 | 1 |
Echinococcus multilocularis | kelch ECH associated protein 1 | 0.0232 | 0.4854 | 0.4854 |
Echinococcus multilocularis | kelch protein 18 | 0.0001 | 0.0001 | 0.0001 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Concentration (functional) | = 100 uM | Minimum concentration producing complete lysis of all trypanosomes within 30 min at 37 degrees C in vitro in the presence of bovine serum albumin. | ChEMBL. | 7097719 |
Max dose (functional) | = 100 mg kg-1 | Maximum tolerated (nonfatal) intraperitoneal dose tested in mice infected with Trypanosoma brucei. | ChEMBL. | 7097719 |
Min lytic concentration (functional) | = 100 uM | Minimum concentration producing complete lysis of all trypanosomes within 30 min at 37 degrees C in vitro | ChEMBL. | 7097719 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.