TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 486.63 | Formula: C24H34N6O3S
H donors: 1 H acceptors: 4 LogP: 1.65 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: OC(Cn1cnc2c1c(=O)n(C)c(=O)n2C)CN1CCN(CC1)CCCCSc1ccccc1
InChi: 1S/C24H34N6O3S/c1-26-22-21(23(32)27(2)24(26)33)30(18-25-22)17-19(31)16-29-13-11-28(12-14-29)10-6-7-15-34-20-8-4-3-5-9-20/h3-5,8-9,18-19,31H,6-7,10-17H2,1-2H3
InChiKey: OAMGCJZVRSAYLH-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	mitogen activated protein kinase 11	0.0516	0.8118	1
Entamoeba histolytica	alcohol dehydrogenase, putative	0.0107	0.1259	0.2206
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0369	0.5661	1
Onchocerca volvulus		0.0565	0.8949	0.9606
Brugia malayi	SH2 domain containing protein	0.0043	0.0185	0.0082
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0369	0.5661	0.6934
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0043	0.0185	0.0304
Schistosoma mansoni	defective proboscis extension response (dpr)-related	0.0038	0.0103	0.0114
Echinococcus granulosus	aldo keto reductase	0.0369	0.5661	0.6934
Trichomonas vaginalis	aldo-keto reductase, putative	0.0369	0.5661	1
Echinococcus multilocularis	aldo keto reductase	0.0369	0.5661	0.6934
Loa Loa (eye worm)	TK/FER protein kinase	0.0043	0.0185	0.0082
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0043	0.0185	0.0101
Echinococcus multilocularis	roundabout 2	0.006	0.0475	0.0464
Loa Loa (eye worm)	TK/FER protein kinase	0.0043	0.0185	0.0082
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0192	0.2693	0.3231
Schistosoma mansoni	tyrosine kinase	0.0043	0.0185	0.0259
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	0.0516	0.8118	1
Leishmania major	aldehyde reductase, putative,oxidoreductase, putative	0.0369	0.5661	0.6418
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0369	0.5661	0.6934
Brugia malayi	Variant SH3 domain containing protein	0.0061	0.0486	0.0386
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0061	0.0486	0.0795
Echinococcus multilocularis	aldo keto reductase	0.0369	0.5661	0.6934
Schistosoma mansoni	growth factor receptor-bound protein	0.0061	0.0486	0.0795
Echinococcus multilocularis	NCK adaptor protein	0.0061	0.0486	0.0477
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0073	0.0689	0.1156
Mycobacterium tuberculosis	Probable oxidoreductase	0.0369	0.5661	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0369	0.5661	0.6934
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0369	0.5661	0.6934
Brugia malayi	Protein kinase domain containing protein	0.0043	0.0185	0.0082
Schistosoma mansoni	aldo-keto reductase	0.0369	0.5661	1
Brugia malayi	hypothetical protein	0.0043	0.0185	0.0082
Schistosoma mansoni	tyrosine kinase	0.0073	0.0689	0.1156
Brugia malayi	protein-tyrosine kinase	0.0162	0.2188	0.2107
Trichomonas vaginalis	aldo/keto reductase, putative	0.0369	0.5661	1
Loa Loa (eye worm)	oxidoreductase	0.0369	0.5661	0.5616
Plasmodium falciparum	aldehyde reductase, putative	0.0107	0.1259	0.5
Echinococcus granulosus	mitogen activated protein kinase 14	0.0516	0.8118	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0369	0.5661	0.6934
Loa Loa (eye worm)	oxidoreductase	0.0369	0.5661	0.5616
Mycobacterium leprae	Conserved hypothetical protein	0.0262	0.3866	0.5922
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0369	0.5661	0.6934
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0043	0.0185	0.0101
Echinococcus granulosus	tyrosine protein kinase Blk	0.0162	0.2188	0.2602
Brugia malayi	Sex muscle abnormal protein 5	0.0061	0.0486	0.0386
Schistosoma mansoni	pol-related	0.0369	0.5661	1
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0192	0.2693	0.3231
Schistosoma mansoni	aldo-keto reductase	0.0369	0.5661	1
Plasmodium falciparum	aldo-keto reductase, putative	0.0107	0.1259	0.5
Echinococcus granulosus	roundabout 2	0.006	0.0475	0.0464
Trypanosoma brucei	mitogen-activated protein kinase 3, putative	0.0516	0.8118	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0043	0.0185	0.0082
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0312	0.0211
Trypanosoma brucei	aldo-keto reductase, putative	0.0369	0.5661	0.6418
Brugia malayi	glutamate-cysteine ligase modifier subunit	0.0107	0.1259	0.1168
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0486	0.0386
Entamoeba histolytica	aldose reductase, putative	0.0369	0.5661	1
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0192	0.2693	0.3231
Brugia malayi	Protein kinase domain containing protein	0.0043	0.0185	0.0082
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0192	0.2693	0.3231
Trypanosoma cruzi	aldo-keto reductase	0.0369	0.5661	0.6418
Leishmania major	prostaglandin f2-alpha synthase/D-arabinose dehydrogenase	0.0369	0.5661	0.6418
Trichomonas vaginalis	aldo-keto reductase, putative	0.0369	0.5661	1
Trypanosoma cruzi	aldo/keto reductase, putative	0.0369	0.5661	0.6418
Loa Loa (eye worm)	CMGC/MAPK/P38 protein kinase	0.0516	0.8118	0.8099
Loa Loa (eye worm)	TK protein kinase	0.0162	0.2188	0.2107
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0369	0.5661	0.6934
Onchocerca volvulus	Tyrosine kinase homolog	0.0587	0.9315	1
Leishmania major	prostaglandin f synthase, putative	0.0369	0.5661	0.6418
Trichomonas vaginalis	aldo-keto reductase, putative	0.0369	0.5661	1
Onchocerca volvulus		0.0043	0.0185	0.0198
Schistosoma mansoni	Neurotrimin precursor (hNT)	0.0038	0.0103	0.0114
Loa Loa (eye worm)	SRC-1	0.0192	0.2693	0.2617
Loa Loa (eye worm)	TK/FER protein kinase	0.0043	0.0185	0.0082
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0369	0.5661	0.6934
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0194	0.2725	0.3271
Entamoeba histolytica	aldose reductase, putative	0.0369	0.5661	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0369	0.5661	0.6934
Onchocerca volvulus		0.0369	0.5661	0.6077
Onchocerca volvulus		0.0369	0.5661	0.6077
Mycobacterium leprae	PROBABLE OXIDOREDUCTASE	0.0369	0.5661	1
Echinococcus granulosus	tyrosine kinase	0.0162	0.2188	0.2602
Leishmania major	mitogen-activated protein kinase 3, putative,map kinase 3, putative	0.0516	0.8118	1
Loa Loa (eye worm)	oxidoreductase	0.0369	0.5661	0.5616
Trichomonas vaginalis	aldo/keto reductase, putative	0.0369	0.5661	1
Echinococcus multilocularis	tyrosine protein kinase shark	0.0043	0.0185	0.0101
Schistosoma mansoni	growth factor receptor-bound protein	0.0061	0.0486	0.0795
Onchocerca volvulus		0.0043	0.0185	0.0198
Schistosoma mansoni	tyrosine kinase	0.0192	0.2693	0.4721
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0369	0.5661	1
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0061	0.0486	0.0386
Leishmania major	aldo-keto reductase-like protein	0.0369	0.5661	0.6418
Schistosoma mansoni	adapter molecule crk	0.0061	0.0486	0.0795
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0192	0.2693	0.3231
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0162	0.2188	0.2602
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0192	0.2693	0.3231
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0192	0.2693	0.3231
Echinococcus granulosus	tyrosine protein kinase HCK	0.0131	0.1671	0.1956
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0369	0.5661	1
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0192	0.2693	0.3231
Loa Loa (eye worm)	glutamate-cysteine ligase modifier subunit	0.0107	0.1259	0.1168
Echinococcus multilocularis	mitogen activated protein kinase 14	0.0516	0.8118	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0369	0.5661	1
Entamoeba histolytica	aldose reductase, putative	0.0369	0.5661	1
Brugia malayi	SH2 domain containing protein	0.0043	0.0185	0.0082
Schistosoma mansoni	nephrin	0.0048	0.0267	0.0405
Loa Loa (eye worm)	oxidoreductase	0.0369	0.5661	0.5616
Schistosoma mansoni	tyrosine kinase	0.0192	0.2693	0.4721
Brugia malayi	Tyrosine-protein kinase abl-1	0.0073	0.0689	0.0592
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0192	0.2693	0.3231
Echinococcus multilocularis	neuroglian	0.0048	0.0267	0.0204
Echinococcus multilocularis	c src tyrosine kinase	0.0073	0.0689	0.0731
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0369	0.5661	0.6934
Giardia lamblia	Aldose reductase	0.0369	0.5661	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0043	0.0185	0.0082
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0043	0.0185	0.0101
Loa Loa (eye worm)	TK/FER protein kinase	0.0043	0.0185	0.0082
Echinococcus granulosus	voltage gated potassium channel subunit	0.0107	0.1259	0.1442
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0369	0.5661	0.5616
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0061	0.0486	0.0386
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0073	0.0689	0.0731
Echinococcus granulosus	aldo keto reductase	0.0369	0.5661	0.6934
Echinococcus granulosus	hypothetical protein	0.0369	0.5661	0.6934
Trichomonas vaginalis	aldo/keto reductase, putative	0.0369	0.5661	1
Entamoeba histolytica	alcohol dehydrogenase, putative	0.0107	0.1259	0.2206
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0369	0.5661	0.6934
Toxoplasma gondii	aldose reductase, putative	0.0369	0.5661	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0369	0.5661	0.6934
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0369	0.5661	0.6934
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0051	0.0312	0.026
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0192	0.2693	0.3231
Echinococcus multilocularis	tyrosine kinase	0.0043	0.0185	0.0101
Schistosoma mansoni	tyrosine kinase	0.0073	0.0689	0.1156
Echinococcus granulosus	aldo keto reductase	0.0369	0.5661	0.6934
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0061	0.0486	0.0477
Loa Loa (eye worm)	hypothetical protein	0.006	0.0475	0.0376
Trypanosoma brucei	prostaglandin f synthase	0.0369	0.5661	0.6418
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0369	0.5661	0.5616
Loa Loa (eye worm)	TK protein kinase	0.0131	0.1671	0.1584
Trichomonas vaginalis	aldo-keto reductase, putative	0.0369	0.5661	1
Brugia malayi	NADH-dependent xylose reductase	0.0107	0.1259	0.1168
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0192	0.2693	0.3231
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0369	0.5661	0.6934
Echinococcus granulosus	growth factor receptor bound protein 2	0.0061	0.0486	0.0477
Loa Loa (eye worm)	TK/ABL protein kinase	0.0043	0.0185	0.0082
Loa Loa (eye worm)	TK/FER protein kinase	0.0043	0.0185	0.0082
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0162	0.2188	0.2602
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0369	0.5661	0.5616
Echinococcus granulosus	twitchin	0.005	0.0298	0.0243
Onchocerca volvulus		0.0043	0.0185	0.0198
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0043	0.0185	0.0101
Echinococcus granulosus	neuroglian	0.0048	0.0267	0.0204
Trichomonas vaginalis	aldo-keto reductase, putative	0.0369	0.5661	1
Echinococcus granulosus	tyrosine kinase	0.0043	0.0185	0.0101
Schistosoma mansoni	vesicular amine transporter	0.0038	0.0103	0.0114
Plasmodium vivax	aldehyde reductase, putative	0.0107	0.1259	0.5
Onchocerca volvulus		0.0369	0.5661	0.6077
Schistosoma mansoni	nck2/grb4	0.0061	0.0486	0.0795
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0369	0.5661	0.6934
Schistosoma mansoni	potassium channel beta	0.0107	0.1259	0.217
Echinococcus multilocularis	aldehyde reductase	0.0262	0.3866	0.4695
Loa Loa (eye worm)	hypothetical protein	0.006	0.0475	0.0376
Trichomonas vaginalis	aldo-keto reductase, putative	0.0369	0.5661	1
Onchocerca volvulus		0.0043	0.0185	0.0198
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0369	0.5661	0.5616
Giardia lamblia	Aldose reductase	0.0369	0.5661	0.5
Echinococcus multilocularis	mitogen activated protein kinase 11	0.0516	0.8118	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0369	0.5661	0.6934
Loa Loa (eye worm)	hypothetical protein	0.0369	0.5661	0.5616
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0073	0.0689	0.0731
Echinococcus multilocularis	aldo keto reductase	0.0369	0.5661	0.6934
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0192	0.2693	0.3231
Echinococcus multilocularis	voltage gated potassium channel subunit	0.0107	0.1259	0.1442
Plasmodium vivax	oxidoreductase, aldo/keto reductase domain containing protein	0.0107	0.1259	0.5
Trichomonas vaginalis	aldo-keto reductase, putative	0.0369	0.5661	1
Onchocerca volvulus		0.0043	0.0185	0.0198
Echinococcus granulosus	c src tyrosine kinase	0.0073	0.0689	0.0731
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0192	0.2693	0.3231
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0369	0.5661	0.6934
Onchocerca volvulus		0.0369	0.5661	0.6077
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0131	0.1671	0.1956
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0192	0.2693	0.3231
Echinococcus multilocularis	mitogen activated protein kinase 11	0.0516	0.8118	1
Schistosoma mansoni	serine/threonine protein kinase	0.0042	0.0172	0.0236
Trichomonas vaginalis	aldo-keto reductase, putative	0.0369	0.5661	1
Echinococcus granulosus	tyrosine protein kinase Srms	0.0043	0.0185	0.0101
Echinococcus granulosus	tyrosine protein kinase shark	0.0043	0.0185	0.0101
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	0.0516	0.8118	1
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0628	1	1
Brugia malayi	Protein kinase domain containing protein	0.0043	0.0185	0.0082
Brugia malayi	Variant SH3 domain containing protein	0.0061	0.0486	0.0386
Loa Loa (eye worm)	oxidoreductase	0.0369	0.5661	0.5616
Entamoeba histolytica	protein kinase, putative	0.0131	0.1671	0.2936
Echinococcus granulosus	tyrosine protein kinase Src42A	0.015	0.1985	0.2348
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0162	0.2188	0.2602
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0185	0.0082
Brugia malayi	P38 map kinase family protein 2	0.0516	0.8118	0.8099
Brugia malayi	Protein kinase domain containing protein	0.0043	0.0185	0.0082
Onchocerca volvulus		0.0369	0.5661	0.6077
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0162	0.2188	0.2602
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0369	0.5661	0.6934
Trichomonas vaginalis	aldo-keto reductase, putative	0.0369	0.5661	1
Onchocerca volvulus		0.0107	0.1259	0.1351
Onchocerca volvulus		0.0369	0.5661	0.6077
Loa Loa (eye worm)	TK/FER protein kinase	0.0043	0.0185	0.0082
Schistosoma mansoni	cell adhesion molecule	0.0051	0.0312	0.0485
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0073	0.0689	0.0731
Echinococcus multilocularis	mitogen activated protein kinase 14	0.0516	0.8118	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0369	0.5661	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0043	0.0185	0.0082
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0192	0.2693	0.3231
Brugia malayi	SRC-1	0.0192	0.2693	0.2617
Echinococcus multilocularis	aldo keto reductase	0.0369	0.5661	0.6934
Onchocerca volvulus		0.0043	0.0185	0.0198
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0369	0.5661	0.6934
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0369	0.5661	0.6934
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0192	0.2693	0.3231
Loa Loa (eye worm)	TK/FER protein kinase	0.0043	0.0185	0.0082
Echinococcus granulosus	NCK adaptor protein	0.0061	0.0486	0.0477
Echinococcus granulosus	aldo keto reductase family 1, member B4	0.0107	0.1259	0.1442
Brugia malayi	Protein kinase domain containing protein	0.0043	0.0185	0.0082
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.015	0.1985	0.2348
Trichomonas vaginalis	aldo-keto reductase, putative	0.0369	0.5661	1
Mycobacterium ulcerans	oxidoreductase	0.0369	0.5661	1
Schistosoma mansoni	tyrosine kinase	0.0043	0.0185	0.0259
Echinococcus granulosus	aldehyde reductase	0.0262	0.3866	0.4695

Activities

Activity type	Activity value	Assay description	Source	Reference
Decrease (functional)	= 0 %	Percent decrease in antiallergic activity by antigen/antibody reaction assay in rat by oral administration at a dose of 10 mg/kg	ChEMBL.	2859374
Decrease (functional)	= 0 %	Percentage decrease in antiallergic activity against cutaneous reaction to histamine in rat, by oral administration at a dose of 10 mg/kg	ChEMBL.	2859374
Decrease (functional)	= 0 %	Percentage decrease in bronchodilator activity against serotonin-induced bronchospasm reaction in guinea pig by intraveneous administration at dose 250 ug/kg	ChEMBL.	2859374
Decrease (functional)	= 13 %	Percent decrease in bronchodilator activity against histamine-induced bronchospasm reaction in guinea pig by intraveneous administration at dose 250 ug/kg	ChEMBL.	2859374
Decrease (functional)	= 34 %	Percent decrease in bronchodilator activity against acetylcholine-induced bronchospasm reaction in guinea pig by intraveneous administration at dose 250 ug/kg	ChEMBL.	2859374

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL158534

Bibliographic References

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Detailed information for compound 273076