Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Serotonin 2a (5-HT2a) receptor | Starlite/ChEMBL | References |
Rattus norvegicus | Adrenergic receptor alpha-1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma japonicum | ko:K04136 adrenergic receptor, alpha 1b, putative | Serotonin 2a (5-HT2a) receptor | 471 aa | 422 aa | 27.5 % |
Echinococcus multilocularis | g protein coupled receptor | Serotonin 2a (5-HT2a) receptor | 471 aa | 462 aa | 21.2 % |
Echinococcus multilocularis | g protein coupled receptor | Serotonin 2a (5-HT2a) receptor | 471 aa | 417 aa | 20.6 % |
Onchocerca volvulus | Ubiquinol-cytochrome-c reductase complex assembly factor 1 homolog | Serotonin 2a (5-HT2a) receptor | 471 aa | 435 aa | 23.0 % |
Echinococcus granulosus | g protein coupled receptor | Serotonin 2a (5-HT2a) receptor | 471 aa | 416 aa | 19.2 % |
Schistosoma japonicum | ko:K04209 neuropeptide Y receptor, invertebrate, putative | Serotonin 2a (5-HT2a) receptor | 471 aa | 405 aa | 25.4 % |
Echinococcus granulosus | g protein coupled receptor | Serotonin 2a (5-HT2a) receptor | 471 aa | 408 aa | 21.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | dual specificity mitogen activated protein | 0.0154 | 0.0751 | 0.0751 |
Trypanosoma brucei | mitogen-activated protein kinase kinase 5 | 0.0154 | 0.0751 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0238 | 0.1427 | 0.1465 |
Toxoplasma gondii | calcium-dependent protein kinase CDPK2A | 0.0062 | 0.0017 | 0.5 |
Trichomonas vaginalis | STE family protein kinase | 0.0154 | 0.0751 | 1 |
Trichomonas vaginalis | STE family protein kinase | 0.0154 | 0.0751 | 1 |
Leishmania major | mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860 | 0.0154 | 0.0751 | 1 |
Toxoplasma gondii | calcium-dependent protein kinase CDPK2B | 0.0062 | 0.0017 | 0.5 |
Schistosoma mansoni | protein kinase | 0.0503 | 0.3553 | 0.3541 |
Entamoeba histolytica | protein kinase, putative | 0.0062 | 0.0017 | 0.5 |
Loa Loa (eye worm) | TK/ALK protein kinase | 0.0238 | 0.1426 | 0.1419 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase type 1 | 0.0062 | 0.0017 | 0.0017 |
Echinococcus multilocularis | dual specificity mitogen activated protein | 0.0154 | 0.0751 | 0.0751 |
Brugia malayi | Dual specificity mitogen-activated protein kinase kinase mek-2 | 0.0154 | 0.0751 | 0.0763 |
Loa Loa (eye worm) | STE/STE7/MEK1 protein kinase | 0.0154 | 0.0751 | 0.0739 |
Entamoeba histolytica | protein kinase, putative | 0.0062 | 0.0017 | 0.5 |
Plasmodium falciparum | calcium-dependent protein kinase 1 | 0.0062 | 0.0017 | 0.5 |
Echinococcus multilocularis | calcium:calmodulin dependent protein kinase type | 0.0062 | 0.0017 | 0.0017 |
Trypanosoma cruzi | mitogen-activated protein kinase kinase 5 | 0.0154 | 0.0751 | 0.5 |
Schistosoma mansoni | protein kinase | 0.0154 | 0.0751 | 0.0735 |
Echinococcus multilocularis | raf serine:threonine protein kinase | 0.1307 | 1 | 1 |
Plasmodium vivax | calcium-dependent protein kinase 3, putative | 0.0062 | 0.0017 | 0.5 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase type | 0.0503 | 0.3553 | 0.3553 |
Echinococcus multilocularis | calcium:calmodulin dependent protein kinase type | 0.0062 | 0.0017 | 0.0017 |
Plasmodium falciparum | calcium-dependent protein kinase 3 | 0.0062 | 0.0017 | 0.5 |
Plasmodium falciparum | calcium-dependent protein kinase 4 | 0.0062 | 0.0017 | 0.5 |
Brugia malayi | Raf kinase | 0.1262 | 0.9635 | 1 |
Giardia lamblia | Kinase, STE STE20 | 0.0154 | 0.0751 | 0.5 |
Plasmodium falciparum | calcium-dependent protein kinase 5 | 0.0062 | 0.0017 | 0.5 |
Trichomonas vaginalis | STE family protein kinase | 0.0154 | 0.0751 | 1 |
Loa Loa (eye worm) | raf kinase | 0.13 | 0.9941 | 1 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase type | 0.0062 | 0.0017 | 0.0017 |
Loa Loa (eye worm) | calcium/calmodulin-dependent protein kinase subunit type II alpha | 0.0441 | 0.3055 | 0.3061 |
Plasmodium vivax | calcium-dependent protein kinase, putative | 0.0062 | 0.0017 | 0.5 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase type | 0.0062 | 0.0017 | 0.0017 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1307 | 1 | 1 |
Echinococcus multilocularis | calcium:calmodulin dependent protein kinase type | 0.0503 | 0.3553 | 0.3553 |
Schistosoma mansoni | protein kinase | 0.0503 | 0.3553 | 0.3541 |
Brugia malayi | Calcium/calmodulin-dependent protein kinase type II alpha chain | 0.0441 | 0.3055 | 0.3158 |
Plasmodium vivax | calcium-dependent protein kinase 1, putative | 0.0062 | 0.0017 | 0.5 |
Echinococcus multilocularis | calcium:calmodulin dependent protein kinase type | 0.0062 | 0.0017 | 0.0017 |
Loa Loa (eye worm) | TKL/RAF/RAF protein kinase | 0.0742 | 0.5465 | 0.549 |
Loa Loa (eye worm) | hypothetical protein | 0.0203 | 0.1145 | 0.1137 |
Plasmodium falciparum | calcium-dependent protein kinase 2 | 0.0062 | 0.0017 | 0.5 |
Schistosoma mansoni | protein kinase | 0.0503 | 0.3553 | 0.3541 |
Plasmodium vivax | calcium-dependent protein kinase 4, putative | 0.0062 | 0.0017 | 0.5 |
Toxoplasma gondii | calcium-dependent protein kinase CDPK3 | 0.0062 | 0.0017 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Kd (functional) | = 6 | Ability to block alpha-1 adrenergic receptor-mediated contractions of rat aorta. | ChEMBL. | 10052973 |
Kd (functional) | = 7.24 | Blocking 5-HT2A receptor-mediated contractions of rat tail artery | ChEMBL. | 10052973 |
pA2 (functional) | = 6 | Ability to block alpha-1 adrenergic receptor-mediated contractions of rat aorta. | ChEMBL. | 10052973 |
pA2 (functional) | = 7.24 | Blocking 5-HT2A receptor-mediated contractions of rat tail artery | ChEMBL. | 10052973 |
Specificity (functional) | = 17 | Specificity towards 5-HT2A receptor to that of alpha-1 adrenoceptor. | ChEMBL. | 10052973 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.