Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Escherichia coli | methionyl-tRNA synthetase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | cyclin dependent kinase | 0.0236 | 1 | 1 |
Plasmodium vivax | protein kinase Crk2 | 0.0236 | 1 | 0.5 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0236 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0236 | 1 | 1 |
Leishmania major | cell division protein kinase 2,cdc2-related kinase | 0.0236 | 1 | 0.5 |
Treponema pallidum | methionyl-tRNA synthetase | 0.0124 | 0.4437 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0233 | 0.9875 | 0.9806 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0236 | 1 | 1 |
Echinococcus multilocularis | cyclin dependent kinase 5 | 0.0236 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0236 | 1 | 1 |
Echinococcus granulosus | cyclin dependent kinase 5 | 0.0236 | 1 | 1 |
Leishmania major | cell division related protein kinase 2,cdc2-related kinase | 0.0236 | 1 | 0.5 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0236 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0236 | 1 | 0.5 |
Echinococcus granulosus | 5'partial|cyclin dependent kinase 1 | 0.0236 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0236 | 1 | 1 |
Echinococcus multilocularis | cyclin dependent kinase | 0.0236 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0236 | 1 | 0.5 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0236 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0236 | 1 | 0.5 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.0236 | 1 | 1 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0236 | 1 | 1 |
Giardia lamblia | Kinase, CMGC CDK | 0.0236 | 1 | 0.5 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0236 | 1 | 1 |
Loa Loa (eye worm) | multisynthetase complex auxiliary component p43 | 0.0107 | 0.3597 | 0.005 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0236 | 1 | 0.5 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.0236 | 1 | 0.5 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.0236 | 1 | 0.5 |
Toxoplasma gondii | cell-cycle-associated protein kinase CDK, putative | 0.0236 | 1 | 1 |
Echinococcus granulosus | cyclin dependent kinase 1 | 0.0236 | 1 | 1 |
Plasmodium falciparum | protein kinase 5 | 0.0236 | 1 | 0.5 |
Loa Loa (eye worm) | CMGC/CDK/CDK5 protein kinase | 0.0236 | 1 | 1 |
Trypanosoma brucei | cdc2-related kinase 3 | 0.0236 | 1 | 0.5 |
Trypanosoma brucei | cdc2-related kinase 1 | 0.0236 | 1 | 0.5 |
Chlamydia trachomatis | methionine--tRNA ligase | 0.0106 | 0.3564 | 0.5 |
Giardia lamblia | Kinase, CMGC CDK | 0.0236 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 4.7 nM | Compound tested for inhibition of Staphylococcus aureus MRS(methionyl tRNA synthetase) in aminoacylation assay | ChEMBL. | 12639554 |
IC50 (binding) | = 4.7 nM | Compound tested for inhibition of Staphylococcus aureus MRS(methionyl tRNA synthetase) in aminoacylation assay | ChEMBL. | 12639554 |
MIC (functional) | < 0.06 ug ml-1 | In vitro Antibacterial activity of compound against Staphylococcus aureus Oxford | ChEMBL. | 12639554 |
MIC (functional) | < 0.06 ug ml-1 | In vitro Antibacterial activity of compound against Enterococcus faecalis 1 | ChEMBL. | 12639554 |
MIC90 (functional) | = 0.25 ug ml-1 | In vitro Antibacterial activity of compound against Staphylococcus aureus | ChEMBL. | 12639554 |
MIC90 (functional) | = 0.25 ug ml-1 | In vitro Antibacterial activity of compound against Staphylococcus epidermidis | ChEMBL. | 12639554 |
MIC90 (functional) | = 0.25 ug ml-1 | In vitro Antibacterial activity of compound against Staphylococcus aureus | ChEMBL. | 12639554 |
MIC90 (functional) | = 0.25 ug ml-1 | In vitro Antibacterial activity of compound against Staphylococcus epidermidis | ChEMBL. | 12639554 |
MIC90 (functional) | = 0.5 ug ml-1 | In vitro Antibacterial activity of compound against Enterococcus faecalis | ChEMBL. | 12639554 |
MIC90 (functional) | = 0.5 ug ml-1 | In vitro Antibacterial activity of compound against Enterococcus faecium | ChEMBL. | 12639554 |
MIC90 (functional) | = 0.5 ug ml-1 | In vitro Antibacterial activity of compound against Enterococcus faecalis | ChEMBL. | 12639554 |
MIC90 (functional) | = 0.5 ug ml-1 | In vitro Antibacterial activity of compound against Enterococcus faecium | ChEMBL. | 12639554 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.