Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | carbonic anhydrase | 0.0619 | 0.3001 | 0.4437 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0619 | 0.3001 | 0.4437 |
Brugia malayi | hypothetical protein | 0.0158 | 0.0631 | 0.0934 |
Leishmania major | carbonic anhydrase family protein, putative | 0.1446 | 0.7253 | 1 |
Mycobacterium ulcerans | thymidine phosphorylase | 0.1256 | 0.6272 | 0.6272 |
Echinococcus multilocularis | carbonic anhydrase II | 0.1351 | 0.6764 | 1 |
Mycobacterium ulcerans | anthranilate phosphoribosyltransferase | 0.0354 | 0.1642 | 0.1642 |
Mycobacterium tuberculosis | Probable anthranilate phosphoribosyltransferase TrpD | 0.0354 | 0.1642 | 0.2301 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0619 | 0.3001 | 0.2929 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.1351 | 0.6764 | 1 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.1351 | 0.6764 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0619 | 0.3001 | 0.4138 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.1351 | 0.6764 | 1 |
Mycobacterium tuberculosis | Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) | 0.0571 | 0.2757 | 0.3884 |
Loa Loa (eye worm) | hypothetical protein | 0.0619 | 0.3001 | 0.2929 |
Wolbachia endosymbiont of Brugia malayi | 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase | 0.0068 | 0.017 | 1 |
Schistosoma mansoni | carbonic anhydrase | 0.0619 | 0.3001 | 0.4138 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0619 | 0.3001 | 0.4437 |
Echinococcus multilocularis | thymidine phosphorylase | 0.1256 | 0.6272 | 0.9274 |
Loa Loa (eye worm) | hypothetical protein | 0.1762 | 0.8873 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.0619 | 0.3001 | 0.4437 |
Schistosoma mansoni | carbonic anhydrase | 0.1446 | 0.7253 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.0619 | 0.3001 | 0.4437 |
Mycobacterium ulcerans | transferase | 0.0065 | 0.0157 | 0.0157 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0619 | 0.3001 | 0.4437 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.1351 | 0.6764 | 1 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase | 0.141 | 0.7064 | 1 |
Mycobacterium leprae | Probable anthranilate phosphoribosyltransferase TrpD | 0.0354 | 0.1642 | 0.2093 |
Echinococcus multilocularis | carbonic anhydrase | 0.0619 | 0.3001 | 0.4437 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.1351 | 0.6764 | 1 |
Onchocerca volvulus | 0.0065 | 0.0157 | 1 | |
Mycobacterium ulcerans | carbonic anhydrase | 0.1446 | 0.7253 | 0.7253 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1981 | 1 | 1 |
Entamoeba histolytica | carbonic anhydrase, putative | 0.1446 | 0.7253 | 1 |
Brugia malayi | hypoxia-induced factor 1 | 0.0145 | 0.0569 | 0.0841 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.1351 | 0.6764 | 0.9326 |
Echinococcus multilocularis | carbonic anhydrase | 0.0619 | 0.3001 | 0.4437 |
Entamoeba histolytica | ankyrin, putative | 0.0068 | 0.017 | 0.0235 |
Loa Loa (eye worm) | hypothetical protein | 0.0619 | 0.3001 | 0.2929 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.0875 | 0.4317 | 0.6099 |
Echinococcus granulosus | carbonic anhydrase II | 0.1351 | 0.6764 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0619 | 0.3001 | 0.4138 |
Wolbachia endosymbiont of Brugia malayi | N-acetylglucosamine-1-phosphate uridyltransferase | 0.0068 | 0.017 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.0619 | 0.3001 | 0.4437 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1981 | 1 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0619 | 0.3001 | 0.5 |
Echinococcus granulosus | dynactin 5 p25 | 0.0068 | 0.017 | 0.0252 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0783 | 0.3846 | 0.5687 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.1351 | 0.6764 | 0.9326 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0619 | 0.3001 | 0.4138 |
Echinococcus granulosus | thymidine phosphorylase | 0.1256 | 0.6272 | 0.9274 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.0631 | 0.0076 |
Entamoeba histolytica | bacterial transferase hexapeptide family protein | 0.0039 | 0.0022 | 0.003 |
Schistosoma mansoni | hypothetical protein | 0.0619 | 0.3001 | 0.4138 |
Schistosoma mansoni | single-minded | 0.0047 | 0.0063 | 0.0087 |
Leishmania major | carbonic anhydrase-like protein | 0.1351 | 0.6764 | 0.9324 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0619 | 0.3001 | 0.4437 |
Mycobacterium tuberculosis | Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase) | 0.1256 | 0.6272 | 0.8876 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.1351 | 0.6764 | 0.746 |
Plasmodium falciparum | carbonic anhydrase | 0.0619 | 0.3001 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0039 | 0.0022 | 0.0022 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.1351 | 0.6764 | 0.746 |
Brugia malayi | PAS domain containing protein | 0.0047 | 0.0063 | 0.0093 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0619 | 0.3001 | 0.4437 |
Mycobacterium tuberculosis | Probable serine acetyltransferase CysE (sat) | 0.0068 | 0.017 | 0.0211 |
Entamoeba histolytica | acetyltransferase, putative | 0.0068 | 0.017 | 0.0235 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.0047 | 0.0063 | 0.0087 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.1446 | 0.7253 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED100 (functional) | = 14 mg kg-1 | Anti-inflammatory activity was assessed by estimating threshold pain response after oral administration to rats | ChEMBL. | 3494124 |
ED30 (functional) | = 20 mg kg-1 | Anti-inflammatory activity was assessed by estimating kaolin-induced edema in rat hind paw, by administering orally | ChEMBL. | 3494124 |
ED50 (functional) | = 2.2 mg kg-1 | Ulcerogenic potential was assessed in a rat model by the enhancement of stress-induced gastric mucosal lesions after oral administration | ChEMBL. | 3494124 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.