Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Escherichia coli | methionyl-tRNA synthetase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Chlamydia trachomatis | methionine--tRNA ligase | 0.0106 | 0.8034 | 0.5 |
Echinococcus multilocularis | methionyl tRNA synthetase, cytoplasmic | 0.0106 | 0.8034 | 0.5 |
Brugia malayi | LBP / BPI / CETP family, N-terminal domain containing protein | 0.0075 | 0.4506 | 0.3939 |
Treponema pallidum | methionyl-tRNA synthetase | 0.0124 | 1 | 0.5 |
Schistosoma mansoni | methionine-tRNA synthetase | 0.0106 | 0.8034 | 0.5 |
Onchocerca volvulus | 0.0075 | 0.4506 | 1 | |
Onchocerca volvulus | 0.0075 | 0.4506 | 1 | |
Onchocerca volvulus | 0.0075 | 0.4506 | 1 | |
Onchocerca volvulus | 0.0075 | 0.4506 | 1 | |
Brugia malayi | LBP / BPI / CETP family, N-terminal domain containing protein | 0.0075 | 0.4506 | 0.3939 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.4506 | 0.4979 |
Echinococcus granulosus | methionyl tRNA synthetase cytoplasmic | 0.0106 | 0.8034 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.8034 | 0.9899 |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0075 | 0.4506 | 0.4979 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0075 | 0.4506 | 0.3939 |
Onchocerca volvulus | 0.0075 | 0.4506 | 1 | |
Onchocerca volvulus | 0.0075 | 0.4506 | 1 | |
Onchocerca volvulus | 0.0075 | 0.4506 | 1 | |
Entamoeba histolytica | methionyl-tRNA synthetase, putative | 0.0124 | 1 | 0.5 |
Onchocerca volvulus | 0.0075 | 0.4506 | 1 | |
Toxoplasma gondii | methionyl-tRNA synthetase | 0.0034 | 0 | 0.5 |
Loa Loa (eye worm) | multisynthetase complex auxiliary component p43 | 0.0107 | 0.8106 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 15 nM | Compound tested for inhibition of Staphylococcus aureus MRS(methionyl tRNA synthetase) in aminoacylation assay | ChEMBL. | 12639554 |
IC50 (binding) | = 15 nM | Compound tested for inhibition of Staphylococcus aureus MRS(methionyl tRNA synthetase) in aminoacylation assay | ChEMBL. | 12639554 |
MIC (functional) | = 4 ug ml-1 | In vitro Antibacterial activity of compound against Staphylococcus aureus Oxford | ChEMBL. | 12639554 |
MIC (functional) | = 4 ug ml-1 | In vitro Antibacterial activity of compound against Enterococcus faecalis 7 | ChEMBL. | 12639554 |
MIC (functional) | = 4 ug ml-1 | In vitro Antibacterial activity of compound against Enterococcus faecalis 7 | ChEMBL. | 12639554 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.