Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | arachidonate 5-lipoxygenase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | arachidonate 5 lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma japonicum | IPR001024,Lipoxygenase, LH2;IPR013819,Lipoxygenase, C-terminal,domain-containing | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma japonicum | ko:K00461 arachidonate 5-lipoxygenase [EC1.13.11.34], putative | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma mansoni | lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma mansoni | lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | integrin alpha | 0.1732 | 0.6289 | 1 |
Schistosoma mansoni | integrin alpha-ps | 0.0404 | 0.1036 | 0.1647 |
Echinococcus granulosus | integrin beta 2 | 0.0457 | 0.1246 | 0.2658 |
Brugia malayi | Integrin alpha cytoplasmic region family protein | 0.131 | 0.462 | 0.6215 |
Schistosoma mansoni | hypothetical protein | 0.0372 | 0.0909 | 0.1446 |
Brugia malayi | Integrin alpha pat-2 precursor | 0.1732 | 0.6289 | 1 |
Echinococcus granulosus | integrin alpha ps | 0.0372 | 0.0909 | 0.1939 |
Echinococcus multilocularis | integrin alpha ps | 0.0777 | 0.2509 | 0.5349 |
Echinococcus granulosus | integrin alpha 3 | 0.1328 | 0.469 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.131 | 0.462 | 0.4082 |
Loa Loa (eye worm) | integrin beta-2 | 0.0618 | 0.1879 | 0.1067 |
Schistosoma mansoni | integrin beta subunit | 0.0364 | 0.0875 | 0.1391 |
Loa Loa (eye worm) | hypothetical protein | 0.136 | 0.4817 | 0.4298 |
Echinococcus multilocularis | integrin alpha ps | 0.0372 | 0.0909 | 0.1939 |
Echinococcus granulosus | integrin alpha ps | 0.0777 | 0.2509 | 0.5349 |
Echinococcus multilocularis | integrin alpha ps | 0.0777 | 0.2509 | 0.5349 |
Loa Loa (eye worm) | hypothetical protein | 0.0956 | 0.3217 | 0.2539 |
Schistosoma mansoni | integrin alpha-ps | 0.0777 | 0.2509 | 0.3989 |
Echinococcus multilocularis | integrin beta 2 | 0.0457 | 0.1246 | 0.2658 |
Loa Loa (eye worm) | hypothetical protein | 0.0404 | 0.1036 | 0.014 |
Echinococcus multilocularis | integrin alpha 3 | 0.1328 | 0.469 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
I (functional) | = 6 % | Percent inhibition was determined for in vivo ionophore induced rat pleurisy at a dose of 3 mg/kg | ChEMBL. | 10691695 |
IC50 (functional) | = 33 nM | Inhibition of calcium ionophore (A-23187)-stimulated LTB4 formation in human neutrophil assay | ChEMBL. | 10691695 |
IC50 (functional) | = 33 nM | Inhibition of calcium ionophore (A-23187)-stimulated LTB4 formation in human neutrophil assay | ChEMBL. | 10691695 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.