Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | carbonic anhydrase | 0.2 | 0.4623 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.0021 | 0.0021 |
Entamoeba histolytica | carbonic anhydrase, putative | 0.146 | 0.3358 | 1 |
Mycobacterium ulcerans | transferase | 0.0066 | 0.0093 | 0.0157 |
Mycobacterium ulcerans | hypothetical protein | 0.0039 | 0.0031 | 0.0022 |
Onchocerca volvulus | 0.0035 | 0.0021 | 0.2222 | |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.4296 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase | 0.146 | 0.3358 | 0.3358 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.4296 | 1 | 1 |
Schistosoma mansoni | single-minded | 0.0047 | 0.005 | 0.005 |
Echinococcus granulosus | carbonic anhydrase | 0.1622 | 0.3737 | 0.3737 |
Echinococcus granulosus | carbonic anhydrase | 0.1622 | 0.3737 | 0.3737 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.1622 | 0.3737 | 0.3737 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase | 0.1423 | 0.3272 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.0021 | 0.0021 |
Entamoeba histolytica | acetyltransferase, putative | 0.0069 | 0.0099 | 0.0235 |
Mycobacterium ulcerans | carbonic anhydrase | 0.146 | 0.3358 | 0.7253 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0021 | 0.0021 |
Schistosoma mansoni | carbonic anhydrase | 0.1622 | 0.3737 | 0.3737 |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 0.0311 | 0.0311 |
Echinococcus multilocularis | transfer RNA-Lys | 0.0035 | 0.0021 | 0.0021 |
Echinococcus granulosus | carbonic anhydrase II | 0.4296 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1622 | 0.3737 | 0.3737 |
Brugia malayi | hypothetical protein | 0.0159 | 0.0311 | 0.0311 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.0883 | 0.2007 | 0.6099 |
Onchocerca volvulus | 0.0066 | 0.0093 | 1 | |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.1622 | 0.3737 | 0.3737 |
Loa Loa (eye worm) | hypothetical protein | 0.2776 | 0.6439 | 0.6439 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.0047 | 0.005 | 0.005 |
Echinococcus multilocularis | carbonic anhydrase | 0.1622 | 0.3737 | 0.3737 |
Brugia malayi | hypothetical protein | 0.0035 | 0.0021 | 0.0021 |
Echinococcus multilocularis | carbonic anhydrase | 0.1622 | 0.3737 | 0.3737 |
Plasmodium falciparum | carbonic anhydrase | 0.1622 | 0.3737 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.2 | 0.4623 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.2 | 0.4623 | 1 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.4296 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase | 0.0069 | 0.0099 | 1 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.1622 | 0.3737 | 0.3737 |
Schistosoma mansoni | carbonic anhydrase-related | 0.1622 | 0.3737 | 0.3737 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.4296 | 1 | 1 |
Entamoeba histolytica | bacterial transferase hexapeptide family protein | 0.0039 | 0.0031 | 0.003 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.4296 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.4296 | 1 | 1 |
Echinococcus granulosus | dynactin 5 p25 | 0.0069 | 0.0099 | 0.0099 |
Echinococcus multilocularis | carbonic anhydrase | 0.1622 | 0.3737 | 0.3737 |
Brugia malayi | PAS domain containing protein | 0.0047 | 0.005 | 0.005 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.0021 | 0.0021 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0791 | 0.1791 | 0.1791 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.1622 | 0.3737 | 0.3737 |
Echinococcus granulosus | carbonic anhydrase | 0.1622 | 0.3737 | 0.3737 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.4296 | 1 | 1 |
Toxoplasma gondii | hypothetical protein | 0.1622 | 0.3737 | 0.5 |
Mycobacterium tuberculosis | Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) | 0.0577 | 0.1289 | 0.3884 |
Echinococcus multilocularis | carbonic anhydrase II | 0.4296 | 1 | 1 |
Leishmania major | carbonic anhydrase family protein, putative | 0.146 | 0.3358 | 0.3338 |
Brugia malayi | bHLH-PAS transcription factor | 0.0035 | 0.0021 | 0.0021 |
Leishmania major | carbonic anhydrase-like protein | 0.4296 | 1 | 1 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.1622 | 0.3737 | 0.3737 |
Schistosoma mansoni | carbonic anhydrase-related | 0.1622 | 0.3737 | 0.3737 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.146 | 0.3358 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1622 | 0.3737 | 0.3737 |
Brugia malayi | hypoxia-induced factor 1 | 0.0147 | 0.0282 | 0.0282 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.1622 | 0.3737 | 0.3737 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0147 | 0.0282 | 0.0282 |
Echinococcus granulosus | single minded 2 | 0.0035 | 0.0021 | 0.0021 |
Entamoeba histolytica | ankyrin, putative | 0.0069 | 0.0099 | 0.0235 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.4296 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.1622 | 0.3737 | 0.3737 |
Wolbachia endosymbiont of Brugia malayi | N-acetylglucosamine-1-phosphate uridyltransferase | 0.0069 | 0.0099 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.1622 | 0.3737 | 0.3737 |
Mycobacterium tuberculosis | Probable serine acetyltransferase CysE (sat) | 0.0069 | 0.0099 | 0.0211 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Licking latency (functional) | = 13 s | Licking latency of the compound was measured after 30 min treatment (at dose=50 mg/kg) by using mouse hot plate test | ChEMBL. | 9513595 |
Licking latency (functional) | = 13 s | Licking latency of the compound was measured after 30 min treatment (at dose=50 mg/kg) by using mouse hot plate test | ChEMBL. | 9513595 |
Licking latency (functional) | = 14 s | Licking latency of the compound was measured after 45 min treatment (at dose=50 mg/kg) by using mouse hot plate test | ChEMBL. | 9513595 |
Licking latency (functional) | = 14 s | Licking latency of the compound was measured after 45 min treatment (at dose=50 mg/kg) by using mouse hot plate test | ChEMBL. | 9513595 |
Licking latency (functional) | = 14.6 s | Licking latency of the compound was measured before treatment (at dose=50 mg/kg) by using mouse hot plate test | ChEMBL. | 9513595 |
Licking latency (functional) | = 14.6 s | Licking latency of the compound was measured before treatment (at dose=50 mg/kg) by using mouse hot plate test | ChEMBL. | 9513595 |
Licking latency (functional) | = 15.8 s | Licking latency of the compound was measured before treatment (at dose=10 mg/kg) by using mouse hot plate test | ChEMBL. | 9513595 |
Licking latency (functional) | = 15.8 s | Licking latency of the compound was measured before treatment (at dose=10 mg/kg) by using mouse hot plate test | ChEMBL. | 9513595 |
Licking latency (functional) | = 16 s | Licking latency of the compound was measured after 15 min treatment (at dose=10 mg/kg) by using mouse hot plate test | ChEMBL. | 9513595 |
Licking latency (functional) | = 16 s | Licking latency of the compound was measured after 15 min treatment (at dose=10 mg/kg) by using mouse hot plate test | ChEMBL. | 9513595 |
Licking latency (functional) | = 16.1 s | Licking latency of the compound was measured after 45 min treatment (at dose=10 mg/kg) by using mouse hot plate test | ChEMBL. | 9513595 |
Licking latency (functional) | = 16.1 s | Licking latency of the compound was measured after 45 min treatment (at dose=10 mg/kg) by using mouse hot plate test | ChEMBL. | 9513595 |
Licking latency (functional) | = 16.7 s | Licking latency of the compound was measured after 30 min treatment (at dose=10 mg/kg) by using mouse hot plate test | ChEMBL. | 9513595 |
Licking latency (functional) | = 16.7 s | Licking latency of the compound was measured after 30 min treatment (at dose=10 mg/kg) by using mouse hot plate test | ChEMBL. | 9513595 |
Licking latency (functional) | = 17 s | Licking latency of the compound was measured after 15 min treatment (at dose=50 mg/kg) by using mouse hot plate test | ChEMBL. | 9513595 |
Licking latency (functional) | = 17 s | Licking latency of the compound was measured after 15 min treatment (at dose=50 mg/kg) by using mouse hot plate test | ChEMBL. | 9513595 |
MAD (functional) | 0 mg kg-1 | MAD: minimal dose able to induce a statistically significant increase of the pain threshold, done on mouse; sc ; IA = inactive | ChEMBL. | 9513595 |
MNTD (functional) | > 50 mg kg-1 | MNTD:Maximal nontoxic dose of the compound, done on mouse; sc | ChEMBL. | 9513595 |
MNTD (functional) | > 50 mg kg-1 | MNTD:Maximal nontoxic dose of the compound, done on mouse; sc | ChEMBL. | 9513595 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.