Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | purine nucleoside phosphorylase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | methylthioadenosine phosphorylase, putative | purine nucleoside phosphorylase | 289 aa | 255 aa | 23.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0154 | 1 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0154 | 1 | 1 |
Mycobacterium leprae | Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP) | 0.0154 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0122 | 0 | 0.5 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0154 | 1 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0154 | 1 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0154 | 1 | 1 |
Giardia lamblia | Purine nucleoside phosphorylase lateral transfer candidate | 0.0154 | 1 | 0.5 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0154 | 1 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0154 | 1 | 1 |
Schistosoma mansoni | purine nucleoside phosphorylase | 0.0154 | 1 | 0.5 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0154 | 1 | 1 |
Mycobacterium tuberculosis | Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP) | 0.0154 | 1 | 0.5 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0154 | 1 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0154 | 1 | 1 |
Trichomonas vaginalis | purine nucleoside phosphorylase I, putative | 0.0154 | 1 | 0.5 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0154 | 1 | 1 |
Mycobacterium ulcerans | purine nucleoside phosphorylase | 0.0154 | 1 | 0.5 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0154 | 1 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0154 | 1 | 1 |
Schistosoma mansoni | purine nucleoside phosphorylase | 0.0154 | 1 | 0.5 |
Onchocerca volvulus | Purine nucleoside phosphorylase homolog | 0.0154 | 1 | 0.5 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0154 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 4.05 nM | Inhibition of Purine nucleoside phosphorylase was evaluated against the enzyme from Human erythrocytic in 50 mM phosphate | ChEMBL. | 8421291 |
IC50 (binding) | = 4.05 nM | Inhibition of Purine nucleoside phosphorylase was evaluated against the enzyme from Human erythrocytic in 50 mM phosphate | ChEMBL. | 8421291 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.