Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | arachidonate 5-lipoxygenase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | IPR001024,Lipoxygenase, LH2;IPR013819,Lipoxygenase, C-terminal,domain-containing | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma mansoni | lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma japonicum | ko:K00461 arachidonate 5-lipoxygenase [EC1.13.11.34], putative | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma mansoni | lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Fibulin-1 precursor | 0.0032 | 0.0287 | 1 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0032 | 0.0287 | 0.5 |
Loa Loa (eye worm) | AStacin protease | 0.0063 | 0.2957 | 0.4721 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1035 | 0.1652 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0032 | 0.0287 | 1 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.01 | 0.6263 | 0.6263 |
Echinococcus granulosus | Tolloid protein 1 | 0.01 | 0.6263 | 0.6153 |
Schistosoma mansoni | lipoxygenase | 0.0142 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.5904 | 0.9427 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.01 | 0.6263 | 1 |
Loa Loa (eye worm) | multiple epidermal growth factor-like domains 6 | 0.0032 | 0.0287 | 0.0458 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0142 | 1 | 1 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0032 | 0.0287 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0287 | 0.0458 |
Echinococcus multilocularis | Tolloid protein 1 | 0.01 | 0.6263 | 0.6153 |
Schistosoma mansoni | lipoxygenase | 0.01 | 0.6221 | 0.6221 |
Onchocerca volvulus | Arrow homolog | 0.0029 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 18 nM | Inhibition of calcium ionophore (A-23187)-stimulated LTB4 formation in human neutrophil assay | ChEMBL. | 10691695 |
IC50 (functional) | = 18 nM | Inhibition of calcium ionophore (A-23187)-stimulated LTB4 formation in human neutrophil assay | ChEMBL. | 10691695 |
NT (functional) | 0 | Effective dose for in vivo ionophore-induced rat pleurisy. | ChEMBL. | 10691695 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.