TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 314.42 | Formula: C16H30N2O4
H donors: 2 H acceptors: 3 LogP: 2.97 Rotable bonds: 11
Rule of 5 violations (Lipinski): 1
SMILES: CCCC[C@@H](C(=O)C(=O)NC(C)(C)C)NC(=O)OC(C)(C)C
InChi: 1S/C16H30N2O4/c1-8-9-10-11(17-14(21)22-16(5,6)7)12(19)13(20)18-15(2,3)4/h11H,8-10H2,1-7H3,(H,17,21)(H,18,20)/t11-/m0/s1
InChiKey: BETXPWDEENHWAI-NSHDSACASA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium vivax	vivapain-2	0.0027	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0253	0.6509
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0253	0.6509
Echinococcus multilocularis	g protein coupled receptor	0.0078	0.0253	0.0984
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0253	0.6509
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0253	0.6509
Schistosoma mansoni	hypothetical protein	0.0078	0.0253	0.0253
Echinococcus granulosus	tm gpcr rhodopsin	0.0078	0.0253	0.0984
Echinococcus granulosus	G protein coupled receptor 139	0.0078	0.0253	0.0984
Echinococcus multilocularis	G protein coupled receptor 139	0.0078	0.0253	0.0984
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0253	0.6509
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0105	0.0388	0.0388
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0388	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0078	0.0253	0.0253
Schistosoma mansoni	neuropeptide receptor	0.0078	0.0253	0.0253
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0078	0.0253	0.0253
Schistosoma mansoni	opsin-like receptor	0.0078	0.0253	0.0253
Schistosoma mansoni	phosphoglucomutase	0.0546	0.2569	0.2569
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0388	1
Brugia malayi	follicle stimulating hormone receptor	0.0078	0.0253	0.0984
Brugia malayi	hypothetical protein	0.0078	0.0253	0.0984
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0078	0.0253	0.0984
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0078	0.0253	0.0984
Brugia malayi	larval opioid receptor	0.0078	0.0253	0.0984
Echinococcus granulosus	biogenic amine 5HT receptor	0.0078	0.0253	0.0984
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0105	0.0388	0.0388
Schistosoma mansoni	cercarial elastase (S01 family)	0.0105	0.0388	0.0388
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0027	0	0.5
Brugia malayi	Pao retrotransposon peptidase family protein	0.0046	0.0096	0.0374
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0078	0.0253	0.0253
Schistosoma mansoni	amine GPCR	0.0078	0.0253	0.0253
Onchocerca volvulus		0.0078	0.0253	0.0984
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0253	0.6509
Echinococcus multilocularis	Peptidase S1 S6, chymotrypsin Hap	0.0105	0.0388	0.1511
Echinococcus granulosus	neuropeptide receptor	0.0078	0.0253	0.0984
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0078	0.0253	0.0253
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0388	1
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0388	1
Echinococcus multilocularis	g protein coupled receptor	0.0078	0.0253	0.0984
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0253	0.6509
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0078	0.0253	0.0984
Echinococcus granulosus	rhodopsin orphan GPCR	0.0078	0.0253	0.0984
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0253	0.6509
Brugia malayi	Dopamine receptor protein 1	0.0078	0.0253	0.0984
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0078	0.0253	0.0984
Brugia malayi	G protein-coupled receptor F59B2.13	0.0078	0.0253	0.0984
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0078	0.0253	0.0984
Echinococcus granulosus	sex peptide receptor	0.0078	0.0253	0.0984
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0078	0.0253	0.0253
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0078	0.0253	0.0253
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0078	0.0253	0.0984
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0078	0.0253	0.0984
Brugia malayi	Pao retrotransposon peptidase family protein	0.0046	0.0096	0.0374
Brugia malayi	hypothetical protein	0.0078	0.0253	0.0984
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0253	0.6509
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.0046	0.0096	0.0374
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0253	0.6509
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0253	0.6509
Brugia malayi	Pao retrotransposon peptidase family protein	0.0046	0.0096	0.0374
Schistosoma mansoni	adenoreceptor	0.0078	0.0253	0.0253
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0078	0.0253	0.0984
Brugia malayi	GnHR receptor homolog	0.0078	0.0253	0.0984
Brugia malayi	hypothetical protein	0.0078	0.0253	0.0984
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0078	0.0253	0.0984
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0253	0.6509
Onchocerca volvulus		0.0078	0.0253	0.0984
Brugia malayi	Dopamine receptor	0.0078	0.0253	0.0984
Brugia malayi	sulfakinin receptor protein	0.0078	0.0253	0.0984
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0078	0.0253	0.0253
Loa Loa (eye worm)	G-protein coupled receptor	0.0078	0.0253	0.6509
Schistosoma mansoni	cercarial elastase (S01 family)	0.0105	0.0388	0.0388
Echinococcus granulosus	enteropeptidase	0.0105	0.0388	0.1511
Echinococcus multilocularis	telomerase reverse transcriptase subunit	0.0046	0.0096	0.0374
Echinococcus multilocularis	somatostatin receptor	0.0078	0.0253	0.0984
Trypanosoma cruzi	hypothetical protein, conserved	0.0046	0.0096	0.0374
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0253	0.6509
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0253	0.6509
Echinococcus granulosus	neuropeptide s receptor	0.0078	0.0253	0.0984
Onchocerca volvulus		0.0078	0.0253	0.0984
Schistosoma mansoni	cercarial elastase (S01 family)	0.0105	0.0388	0.0388
Brugia malayi	Zinc knuckle family protein	0.0046	0.0096	0.0374
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0078	0.0253	0.0984
Trypanosoma brucei	SLACS retrotransposable element (part), putative	0.0046	0.0096	0.0096
Echinococcus granulosus	rhodopsin orphan GPCR	0.0078	0.0253	0.0984
Echinococcus granulosus	neuropeptide receptor	0.0078	0.0253	0.0984
Echinococcus multilocularis	transmembrane protease serine 3	0.0105	0.0388	0.1511
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.0046	0.0096	0.0374
Leishmania major	ribonuclease H1, putative	0.0546	0.2569	1
Echinococcus multilocularis	glycoprotein Antigen 5	0.0105	0.0388	0.1511
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0078	0.0253	0.6509
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0253	0.6509
Echinococcus multilocularis	g protein coupled receptor	0.0078	0.0253	0.0984
Brugia malayi	hypothetical protein	0.0046	0.0096	0.0374
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0253	0.6509
Schistosoma mansoni	cercarial elastase (S01 family)	0.0105	0.0388	0.0388
Schistosoma mansoni	serine/threonine protein kinase	0.0046	0.0096	0.0096
Schistosoma mansoni	neuropeptide receptor	0.0078	0.0253	0.0253
Onchocerca volvulus		0.0105	0.0388	0.1511
Schistosoma mansoni	hypothetical protein	0.0046	0.0096	0.0096
Onchocerca volvulus		0.0078	0.0253	0.0984
Plasmodium vivax	vivapain-2	0.0027	0	0.5
Brugia malayi	putative neuropeptide receptor NPR1	0.0078	0.0253	0.0984
Echinococcus granulosus	rhodopsin orphan GPCR	0.0078	0.0253	0.0984
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0078	0.0253	0.0984
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.0046	0.0096	0.0374
Echinococcus granulosus	Peptidase S1 S6 chymotrypsin Hap	0.0105	0.0388	0.1511
Trichomonas vaginalis	reverse transcriptases, putative	0.0046	0.0096	0.0374
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0105	0.0388	0.0388
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0078	0.0253	0.0253
Echinococcus granulosus	neuropeptide Y receptor	0.0078	0.0253	0.0984
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0253	0.6509
Onchocerca volvulus		0.0078	0.0253	0.0984
Echinococcus granulosus	neuropeptides capa receptor	0.0078	0.0253	0.0984
Schistosoma mansoni	biogenic amine receptor	0.0078	0.0253	0.0253
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0078	0.0253	0.0984
Trypanosoma brucei	RNA helicase, putative	0.2049	1	1
Brugia malayi	Trypsin family protein	0.0105	0.0388	0.1511
Brugia malayi	hypothetical protein	0.0078	0.0253	0.0984
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0253	0.6509
Echinococcus granulosus	rhodopsin orphan GPCR	0.0078	0.0253	0.0984
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0078	0.0253	0.6509
Brugia malayi	RE15519p	0.0078	0.0253	0.0984
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0388	1
Schistosoma mansoni	biogenic amine receptor	0.0078	0.0253	0.0253
Echinococcus granulosus	somatostatin receptor	0.0078	0.0253	0.0984
Entamoeba histolytica	cysteine protease, putative	0.0027	0	0.5
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0078	0.0253	0.0253
Onchocerca volvulus		0.0078	0.0253	0.0984
Echinococcus granulosus	tm gpcr rhodopsin	0.0078	0.0253	0.0984
Brugia malayi	Serotonin receptor	0.0078	0.0253	0.0984
Brugia malayi	Pao retrotransposon peptidase family protein	0.0046	0.0096	0.0374
Onchocerca volvulus		0.0078	0.0253	0.0984
Loa Loa (eye worm)	G-protein coupled receptor	0.0078	0.0253	0.6509
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0078	0.0253	0.0984
Echinococcus multilocularis	sex peptide receptor	0.0078	0.0253	0.0984
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0253	0.6509
Onchocerca volvulus		0.0078	0.0253	0.0984
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0253	0.6509
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0253	0.6509
Giardia lamblia	Ribonuclease H	0.0546	0.2569	1
Brugia malayi	Dopamine receptor protein 2	0.0078	0.0253	0.0984
Brugia malayi	hypothetical protein	0.0078	0.0253	0.0984
Schistosoma mansoni	amine GPCR	0.0078	0.0253	0.0253
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0078	0.0253	0.6509
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0078	0.0253	0.0984
Echinococcus granulosus	RNA directed DNA polymerase	0.0046	0.0096	0.0374
Echinococcus granulosus	orexin receptor type 2	0.0078	0.0253	0.0984
Echinococcus granulosus	fmrfamide receptor	0.0078	0.0253	0.0984
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0078	0.0253	0.0984
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0078	0.0253	0.0984
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0253	0.6509
Loa Loa (eye worm)	trypsin family protein	0.0105	0.0388	1
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0078	0.0253	0.0984
Echinococcus granulosus	subfamily S1A unassigned peptidase S01 family	0.0105	0.0388	0.1511
Brugia malayi	ORL1-like opioid receptor	0.0078	0.0253	0.0984
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0078	0.0253	0.0984
Onchocerca volvulus		0.0078	0.0253	0.0984
Brugia malayi	hypothetical protein	0.0046	0.0096	0.0374
Schistosoma mansoni	scy1(yeast) protein kinase-like	0.0046	0.0096	0.0096
Trypanosoma brucei	retrotransposon hot spot protein 4 (RHS4), interrupted	0.0593	0.2798	0.2798
Echinococcus granulosus	KRAB A domain containing protein	0.0046	0.0096	0.0374
Echinococcus granulosus	RNA directed DNA polymerase reverse transcriptase	0.0046	0.0096	0.0374
Brugia malayi	G-protein coupled receptor	0.0078	0.0253	0.0984
Schistosoma mansoni	hypothetical protein	0.0105	0.0388	0.0388
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0078	0.0253	0.0253
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0253	0.6509
Trypanosoma brucei	ingi protein (ORF1)	0.0593	0.2798	0.2798
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.0046	0.0096	0.0374
Onchocerca volvulus		0.0078	0.0253	0.0984
Onchocerca volvulus		0.0105	0.0388	0.1511
Echinococcus multilocularis	neuropeptides capa receptor	0.0078	0.0253	0.0984
Schistosoma mansoni	opsin-like receptor	0.0078	0.0253	0.0253
Entamoeba histolytica	cysteine proteinase, putative	0.0027	0	0.5
Echinococcus multilocularis	neuropeptides capa receptor	0.0078	0.0253	0.0984
Onchocerca volvulus		0.0078	0.0253	0.0984
Echinococcus multilocularis	neuropeptide receptor	0.0078	0.0253	0.0984
Echinococcus granulosus	dro:myosuppressin receptor	0.0078	0.0253	0.0984
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0253	0.6509
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0078	0.0253	0.0984
Brugia malayi	Zinc knuckle family protein	0.0046	0.0096	0.0374
Echinococcus granulosus	RNA directed DNA polymerase reverse transcriptase	0.0046	0.0096	0.0374
Brugia malayi	reverse transcriptase	0.0046	0.0096	0.0374
Schistosoma mansoni	neuropeptide F-like receptor	0.0078	0.0253	0.0253
Brugia malayi	Trypsin family protein	0.0105	0.0388	0.1511
Echinococcus multilocularis	orexin receptor type 2	0.0078	0.0253	0.0984
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0253	0.6509
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0388	1
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0105	0.0388	0.0388
Brugia malayi	AKH receptor	0.0078	0.0253	0.0984
Schistosoma mansoni	histamine h1 receptor	0.0078	0.0253	0.0253
Echinococcus granulosus	serotonin receptor	0.0078	0.0253	0.0984
Echinococcus multilocularis	Mastin	0.0105	0.0388	0.1511
Echinococcus granulosus	hypothetical protein	0.0078	0.0253	0.0984
Entamoeba histolytica	cysteine proteinase, putative	0.0027	0	0.5
Echinococcus multilocularis	subfamily S1A unassigned peptidase (S01 family)	0.0105	0.0388	0.1511
Schistosoma mansoni	phosphoglucomutase	0.0546	0.2569	0.2569
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0253	0.6509
Trypanosoma brucei	ribonuclease H1	0.0546	0.2569	0.2569
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0078	0.0253	0.0984
Echinococcus granulosus	allatostatin A receptor	0.0078	0.0253	0.0984
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0078	0.0253	0.0984
Echinococcus multilocularis	neuropeptide Y receptor	0.0078	0.0253	0.0984
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.0046	0.0096	0.0374
Schistosoma mansoni	protein kinase	0.0046	0.0096	0.0096
Onchocerca volvulus		0.0105	0.0388	0.1511
Echinococcus multilocularis	RNA directed DNA polymerase	0.0046	0.0096	0.0374
Echinococcus granulosus	g-protein coupled receptor	0.0078	0.0253	0.0984
Schistosoma mansoni	amine GPCR	0.0078	0.0253	0.0253
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0078	0.0253	0.0984
Schistosoma mansoni	hypothetical protein	0.0078	0.0253	0.0253
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0078	0.0253	0.0984
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0078	0.0253	0.0253
Trypanosoma cruzi	ribonuclease H1, putative	0.0546	0.2569	1
Brugia malayi	hypothetical protein	0.0078	0.0253	0.0984
Schistosoma mansoni	neuropeptide receptor	0.0078	0.0253	0.0253
Brugia malayi	reverse transcriptase	0.0046	0.0096	0.0374
Echinococcus granulosus	rhodopsin orphan GPCR	0.0078	0.0253	0.0984
Echinococcus granulosus	rhodopsin orphan GPCR	0.0078	0.0253	0.0984
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0253	0.6509
Brugia malayi	hypothetical protein	0.0046	0.0096	0.0374
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0253	0.6509
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0078	0.0253	0.0984
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0253	0.6509
Schistosoma mansoni	growth hormone secretagogue receptor	0.0078	0.0253	0.0253
Echinococcus granulosus	neuropeptides capa receptor	0.0078	0.0253	0.0984
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0253	0.6509
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0253	0.6509
Echinococcus multilocularis	serotonin receptor	0.0078	0.0253	0.0984
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0253	0.6509
Loa Loa (eye worm)	neuropeptide F receptor	0.0078	0.0253	0.6509
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0253	0.6509
Brugia malayi	RNase H family protein	0.0546	0.2569	1
Brugia malayi	Pao retrotransposon peptidase family protein	0.0046	0.0096	0.0374
Echinococcus multilocularis	dro:myosuppressin receptor	0.0078	0.0253	0.0984
Echinococcus multilocularis	neuropeptide s receptor	0.0078	0.0253	0.0984
Echinococcus granulosus	RNA directed DNA polymerase reverse transcriptase	0.0046	0.0096	0.0374
Schistosoma mansoni	hypothetical protein	0.0078	0.0253	0.0253
Brugia malayi	hypothetical protein	0.0046	0.0096	0.0374
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0253	0.6509
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0388	1
Brugia malayi	hypothetical protein	0.0078	0.0253	0.0984
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0253	0.6509
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0078	0.0253	0.0984
Toxoplasma gondii	ribonuclease HI protein	0.0546	0.2569	1
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0078	0.0253	0.0253
Brugia malayi	neuropeptide F receptor	0.0078	0.0253	0.0984
Trypanosoma brucei	Endonuclease-reverse transcriptase/Reverse transcriptase (RNA-dependent DNA polymerase), putative	0.0046	0.0096	0.0096
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0078	0.0253	0.0253
Trypanosoma brucei	unspecified product	0.0593	0.2798	0.2798
Echinococcus granulosus	ribonuclease H1	0.0546	0.2569	1
Schistosoma mansoni	cercarial elastase (S01 family)	0.0105	0.0388	0.0388
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0078	0.0253	0.6509
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0253	0.6509
Onchocerca volvulus	Telomerase reverse transcriptase homolog	0.0046	0.0096	0.0374
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0078	0.0253	0.0984
Wolbachia endosymbiont of Brugia malayi	ribonuclease HI	0.0546	0.2569	0.5
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0253	0.6509
Echinococcus multilocularis	fmrfamide receptor	0.0078	0.0253	0.0984
Trichomonas vaginalis	NeSL-1_NeSL reverse transcriptases, putative	0.0046	0.0096	0.0374
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0027	0	0.5
Brugia malayi	Trypsin family protein	0.0105	0.0388	0.1511
Schistosoma mansoni	cercarial elastase (S01 family)	0.0105	0.0388	0.0388
Echinococcus granulosus	RNA directed DNA polymerase reverse transcriptase	0.0046	0.0096	0.0374
Echinococcus multilocularis	serotonin receptor	0.0078	0.0253	0.0984
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0078	0.0253	0.0253
Treponema pallidum	ribonuclease H (rnhA)	0.0546	0.2569	0.5
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0253	0.6509
Onchocerca volvulus		0.0046	0.0096	0.0374
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0078	0.0253	0.0253
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0078	0.0253	0.0253
Brugia malayi	Pao retrotransposon peptidase family protein	0.0046	0.0096	0.0374
Schistosoma mansoni	neuropeptide receptor	0.0078	0.0253	0.0253
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0078	0.0253	0.0253
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0078	0.0253	0.0984
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0078	0.0253	0.0984
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0105	0.0388	0.0388
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0078	0.0253	0.0984
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0078	0.0253	0.0253
Schistosoma mansoni	myosin xvIII	0.0078	0.0253	0.0253
Echinococcus granulosus	transmembrane protease serine 3	0.0105	0.0388	0.1511
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0078	0.0253	0.0253
Onchocerca volvulus		0.0046	0.0096	0.0374
Loa Loa (eye worm)	neuropeptide F receptor	0.0078	0.0253	0.6509
Brugia malayi	Pao retrotransposon peptidase family protein	0.0046	0.0096	0.0374
Schistosoma mansoni	neuropeptide f receptor 76f	0.0078	0.0253	0.0253
Brugia malayi	Trypsin family protein	0.0105	0.0388	0.1511
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0078	0.0253	0.0253
Onchocerca volvulus		0.0078	0.0253	0.0984
Schistosoma mansoni	cercarial elastase (S01 family)	0.0105	0.0388	0.0388
Echinococcus granulosus	g protein coupled receptor	0.0078	0.0253	0.0984
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0078	0.0253	0.0984
Brugia malayi	Melatonin receptor type 1A	0.0078	0.0253	0.0984
Brugia malayi	Pao retrotransposon peptidase family protein	0.0046	0.0096	0.0374
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0078	0.0253	0.6509
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0078	0.0253	0.0984
Echinococcus granulosus	g protein coupled receptor	0.0078	0.0253	0.0984
Schistosoma mansoni	cercarial elastase (S01 family)	0.0105	0.0388	0.0388
Brugia malayi	hypothetical protein	0.0105	0.0388	0.1511
Brugia malayi	Serotonin receptor	0.0078	0.0253	0.0984
Schistosoma mansoni	hypothetical protein	0.0046	0.0096	0.0096
Echinococcus granulosus	neuropeptide Y receptor	0.0078	0.0253	0.0984
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.0046	0.0096	0.0374
Brugia malayi	RNase H family protein	0.0546	0.2569	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0078	0.0253	0.0984
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0078	0.0253	0.0984
Brugia malayi	G-protein coupled receptor	0.0078	0.0253	0.0984
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0078	0.0253	0.0253
Echinococcus multilocularis	neuropeptide receptor	0.0078	0.0253	0.0984
Onchocerca volvulus		0.0105	0.0388	0.1511
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.0046	0.0096	0.0374
Schistosoma mansoni	cercarial elastase (S01 family)	0.0105	0.0388	0.0388
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0253	0.6509
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0078	0.0253	0.0984
Echinococcus granulosus	glycoprotein Antigen 5	0.0105	0.0388	0.1511
Echinococcus multilocularis	fmrfamide receptor	0.0078	0.0253	0.0984
Echinococcus granulosus	7tm_1 domain containing protein	0.0078	0.0253	0.0984
Onchocerca volvulus		0.0078	0.0253	0.0984
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0105	0.0388	0.0388
Trypanosoma cruzi	ribonuclease H1, putative	0.0546	0.2569	1
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.0046	0.0096	0.0374
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0078	0.0253	0.0984
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0078	0.0253	0.0984
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0253	0.6509
Trichomonas vaginalis	ribonuclease H1, putative	0.0546	0.2569	1
Schistosoma mansoni	cercarial elastase (S01 family)	0.0105	0.0388	0.0388
Echinococcus granulosus	neuropeptide FF receptor 2	0.0078	0.0253	0.0984
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0078	0.0253	0.0253
Loa Loa (eye worm)	TYRA-2 protein	0.0078	0.0253	0.6509
Schistosoma mansoni	amine GPCR	0.0078	0.0253	0.0253
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0078	0.0253	0.0984
Echinococcus granulosus	tm gpcr rhodopsin	0.0078	0.0253	0.0984
Onchocerca volvulus		0.0078	0.0253	0.0984
Brugia malayi	G protein-coupled receptor	0.0078	0.0253	0.0984
Echinococcus granulosus	neuropeptide receptor A26	0.0078	0.0253	0.0984
Schistosoma mansoni	hypothetical protein	0.0105	0.0388	0.0388
Schistosoma mansoni	cercarial elastase (S01 family)	0.0105	0.0388	0.0388
Brugia malayi	Pao retrotransposon peptidase family protein	0.0046	0.0096	0.0374
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0105	0.0388	0.0388
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0027	0	0.5
Brugia malayi	Pao retrotransposon peptidase family protein	0.0046	0.0096	0.0374
Brugia malayi	Pao retrotransposon peptidase family protein	0.0046	0.0096	0.0374
Echinococcus granulosus	rhodopsin orphan GPCR	0.0078	0.0253	0.0984
Onchocerca volvulus		0.0078	0.0253	0.0984
Echinococcus multilocularis	enteropeptidase	0.0105	0.0388	0.1511
Mycobacterium ulcerans	hypothetical protein	0.0105	0.0388	0.5
Brugia malayi	Chymotrypsin-like protease CTRL-1 precursor	0.0105	0.0388	0.1511
Brugia malayi	RNase H family protein	0.0546	0.2569	1
Schistosoma mansoni	opsin-like receptor	0.0078	0.0253	0.0253
Schistosoma mansoni	phosphoglucomutase	0.0546	0.2569	0.2569
Schistosoma mansoni	biogenic amine receptor	0.0078	0.0253	0.0253
Brugia malayi	hypothetical protein	0.0078	0.0253	0.0984
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0078	0.0253	0.0253
Echinococcus multilocularis	RNA directed DNA polymerase (reverse transcriptase)	0.0046	0.0096	0.0374
Brugia malayi	hypothetical protein	0.0078	0.0253	0.0984
Echinococcus granulosus	Mastin	0.0105	0.0388	0.1511
Trichomonas vaginalis	reverse transcriptases, putative	0.0046	0.0096	0.0374
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0078	0.0253	0.0984
Echinococcus multilocularis	neuropeptide receptor A26	0.0078	0.0253	0.0984
Trypanosoma brucei	ingi protein (ORF1)	0.0593	0.2798	0.2798
Schistosoma mansoni	hypothetical protein	0.0078	0.0253	0.0253
Echinococcus granulosus	7TM GPCR rhodopsin	0.0078	0.0253	0.0984
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0105	0.0388	0.0388
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0078	0.0253	0.0984
Echinococcus granulosus	biogenic amine 5HT receptor	0.0078	0.0253	0.0984
Schistosoma mansoni	neuropeptide F-like receptor	0.0078	0.0253	0.0253
Schistosoma mansoni	amine GPCR	0.0078	0.0253	0.0253
Brugia malayi	reverse transcriptase	0.0046	0.0096	0.0374
Trypanosoma brucei	SLACS reverse transcriptase, putative	0.0046	0.0096	0.0096
Onchocerca volvulus		0.0105	0.0388	0.1511
Brugia malayi	neuropeptide F receptor	0.0078	0.0253	0.0984
Onchocerca volvulus	Ribonuclease H1 homolog	0.0546	0.2569	1
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0078	0.0253	0.0984
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0078	0.0253	0.0253
Brugia malayi	Pao retrotransposon peptidase family protein	0.0046	0.0096	0.0374
Loa Loa (eye worm)	melatonin receptor type 1A	0.0078	0.0253	0.6509
Echinococcus multilocularis	allatostatin A receptor	0.0078	0.0253	0.0984
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0253	0.6509
Echinococcus multilocularis	ribonuclease H1	0.0546	0.2569	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0078	0.0253	0.0253
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0253	0.6509
Brugia malayi	putative neuropeptide receptor	0.0078	0.0253	0.0984
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0253	0.6509
Onchocerca volvulus		0.0078	0.0253	0.0984
Brugia malayi	hypothetical protein	0.0078	0.0253	0.0984
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0078	0.0253	0.0984
Brugia malayi	Pao retrotransposon peptidase family protein	0.0046	0.0096	0.0374
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0078	0.0253	0.0984
Onchocerca volvulus		0.0078	0.0253	0.0984
Echinococcus multilocularis	g-protein coupled receptor	0.0078	0.0253	0.0984
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0253	0.6509
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0253	0.6509
Echinococcus granulosus	g protein coupled receptor	0.0078	0.0253	0.0984
Brugia malayi	Pao retrotransposon peptidase family protein	0.0046	0.0096	0.0374
Trichomonas vaginalis	reverse transcriptase [C. elegans], putative	0.0046	0.0096	0.0374
Trypanosoma brucei	hypothetical protein, conserved	0.0593	0.2798	0.2798
Mycobacterium tuberculosis	Possible maturase	0.0046	0.0096	0.5
Onchocerca volvulus		0.0105	0.0388	0.1511
Brugia malayi	Trypsin-like protease protein 5	0.0105	0.0388	0.1511

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	> 100 uM	Inhibitory activity against human cathepsin K	ChEMBL.	14741275
IC50 (binding)	> 100 uM	Inhibitory activity against human cathepsin K	ChEMBL.	14741275

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 276695