Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Neprilysin | Starlite/ChEMBL | No references |
Homo sapiens | angiotensin I converting enzyme 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | Neprilysin | 750 aa | 682 aa | 31.1 % | |
Onchocerca volvulus | Neprilysin | 750 aa | 713 aa | 34.1 % | |
Schistosoma mansoni | family M13 non-peptidase homologue (M13 family) | Neprilysin | 750 aa | 778 aa | 20.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | endothelin converting enzyme 1 | 0.0114 | 0.4078 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.2073 | 0.0177 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.2073 | 0.0177 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.4078 | 0.2662 |
Mycobacterium tuberculosis | Probable zinc metalloprotease Zmp1 | 0.0114 | 0.4078 | 0.5 |
Mycobacterium ulcerans | zinc metalloprotease | 0.0114 | 0.4078 | 0.5 |
Loa Loa (eye worm) | angiotensin-converting enzyme family protein | 0.0196 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.2073 | 0.0177 |
Toxoplasma gondii | peptidase family M13 protein | 0.0114 | 0.4078 | 0.5 |
Echinococcus multilocularis | endothelin converting enzyme 1 | 0.0114 | 0.4078 | 0.5 |
Mycobacterium leprae | probable zinc metalloprotease | 0.0114 | 0.4078 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.4078 | 0.2662 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.2073 | 0.0177 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.2073 | 0.0177 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0114 | 0.4078 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.2073 | 0.0177 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.4078 | 0.2662 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Duration of action (functional) | = 70 min | Time taken for 50 % or more inhibition of angiotensin-I (AI) induced pressor response in normotensive rats | ChEMBL. | No reference |
IC50 (binding) | = 33 nM | Inhibition of neutral endopeptidase (NEP) 24.11 | ChEMBL. | No reference |
IC50 (binding) | = 33 nM | Inhibition of neutral endopeptidase (NEP) 24.11 | ChEMBL. | No reference |
IC50 (binding) | = 175 nM | Inhibition of angiotensin converting enzyme (ACE) | ChEMBL. | No reference |
IC50 (binding) | = 175 nM | Inhibition of angiotensin converting enzyme (ACE) | ChEMBL. | No reference |
Inhibition (functional) | = 10 mg kg-1 | Compound concentration that causes inhibition of angiotensin-I (AI) induced pressor response in normotensive rats after intraarterial injection | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.