Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | farnesyltransferase, CAAX box, alpha | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0144 | 0.5538 | 1 | |
Onchocerca volvulus | 0.0144 | 0.5538 | 1 | |
Onchocerca volvulus | 0.0144 | 0.5538 | 1 | |
Echinococcus multilocularis | protein farnesyltransferase alpha subunit | 0.0193 | 1 | 0.5 |
Echinococcus granulosus | protein farnesyltransferase alpha subunit | 0.0193 | 1 | 0.5 |
Onchocerca volvulus | 0.0144 | 0.5538 | 1 | |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative | 0.0193 | 1 | 1 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit, putative | 0.0193 | 1 | 1 |
Entamoeba histolytica | protein farnesyltransferase alpha subunit, putative | 0.0193 | 1 | 0.5 |
Loa Loa (eye worm) | prenyltransferase alpha subunit repeat containing protein | 0.0193 | 1 | 1 |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0144 | 0.5538 | 0.5538 |
Loa Loa (eye worm) | hypothetical protein | 0.0144 | 0.5538 | 0.5538 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0144 | 0.5538 | 0.5538 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 1 | 1 |
Brugia malayi | LBP / BPI / CETP family, N-terminal domain containing protein | 0.0144 | 0.5538 | 0.5538 |
Schistosoma mansoni | protein farnesyltransferase alpha subunit | 0.0193 | 1 | 0.5 |
Plasmodium falciparum | protein farnesyltransferase subunit alpha | 0.0193 | 1 | 0.5 |
Onchocerca volvulus | 0.0144 | 0.5538 | 1 | |
Onchocerca volvulus | 0.0144 | 0.5538 | 1 | |
Plasmodium vivax | prenyltransferase alpha subunit, putative | 0.0193 | 1 | 0.5 |
Brugia malayi | LBP / BPI / CETP family, N-terminal domain containing protein | 0.0144 | 0.5538 | 0.5538 |
Toxoplasma gondii | hypothetical protein | 0.0143 | 0.5478 | 0.5 |
Onchocerca volvulus | 0.0144 | 0.5538 | 1 | |
Giardia lamblia | Rab geranylgeranyltransferase | 0.0193 | 1 | 0.5 |
Onchocerca volvulus | 0.0144 | 0.5538 | 1 | |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit, putative | 0.0193 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 340 nM | Inhibition of rate of incorporation of [3H]-FPP into recombinant Ras-CVIM by human farnesyltransferase. | ChEMBL. | 11392531 |
IC50 (binding) | = 340 nM | Inhibition of rate of incorporation of [3H]-FPP into recombinant Ras-CVIM by human farnesyltransferase. | ChEMBL. | 11392531 |
IC50 (binding) | = 28000 nM | Inhibition of rate of incorporation of [3H]-GGPP into a biotinylated peptide corresponding to C-terminus of human Ki-Ras by human geranylgeranyl-transferase type I. | ChEMBL. | 11392531 |
IC50 (binding) | = 28000 nM | Inhibition of rate of incorporation of [3H]-GGPP into a biotinylated peptide corresponding to C-terminus of human Ki-Ras by human geranylgeranyl-transferase type I. | ChEMBL. | 11392531 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.