Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | serpin precursor | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 402 aa | 383 aa | 22.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0226 | 0.0093 | 0.0044 |
Brugia malayi | Matrixin family protein | 0.0186 | 0.0051 | 0.0094 |
Mycobacterium ulcerans | peptide deformylase | 0.9907 | 1 | 1 |
Trypanosoma brucei | Peptide deformylase 2 | 0.378 | 0.373 | 0.5 |
Brugia malayi | Matrixin family protein | 0.0186 | 0.0051 | 0.0094 |
Schistosoma mansoni | ADAM17 peptidase (M12 family) | 0.0421 | 0.0292 | 1 |
Mycobacterium ulcerans | hydrolase | 0.0226 | 0.0093 | 0.0044 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0675 | 0.0552 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0186 | 0.0051 | 0.0672 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.0003 | 0.0043 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.0003 | 0.0043 |
Echinococcus multilocularis | a disintegrin and metalloproteinase with | 0.0199 | 0.0065 | 0.0315 |
Plasmodium falciparum | peptide deformylase | 0.9907 | 1 | 0.5 |
Onchocerca volvulus | 0.0263 | 0.0131 | 0.3431 | |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.0049 | 0.0639 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0226 | 0.0093 | 0.1617 |
Echinococcus multilocularis | adam 17 protease | 0.0421 | 0.0292 | 0.4829 |
Brugia malayi | metalloprotease disintegrin 16 with thrombospondin type I motif | 0.0199 | 0.0065 | 0.0583 |
Plasmodium vivax | peptide deformylase, putative | 0.9907 | 1 | 0.5 |
Brugia malayi | Matrixin family protein | 0.0449 | 0.0321 | 1 |
Loa Loa (eye worm) | matrixin family protein | 0.0412 | 0.0283 | 0.3693 |
Loa Loa (eye worm) | hypothetical protein | 0.0186 | 0.0051 | 0.0672 |
Loa Loa (eye worm) | matrix metalloproteinase | 0.0186 | 0.0051 | 0.0672 |
Loa Loa (eye worm) | matrixin family protein | 0.0449 | 0.0321 | 0.4189 |
Toxoplasma gondii | hypothetical protein | 0.9907 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.0003 | 0.0043 |
Mycobacterium tuberculosis | Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) | 0.9907 | 1 | 1 |
Treponema pallidum | polypeptide deformylase (def) | 0.9907 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | peptide deformylase | 0.9907 | 1 | 0.5 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.378 | 0.373 | 0.5 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.378 | 0.373 | 0.5 |
Leishmania major | polypeptide deformylase-like protein, putative | 0.378 | 0.373 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0186 | 0.0051 | 0.0672 |
Mycobacterium tuberculosis | Possible exported protein | 0.1491 | 0.1387 | 0.1345 |
Schistosoma mansoni | ADAMTS5 peptidase (M12 family) | 0.0199 | 0.0065 | 0.1988 |
Echinococcus granulosus | Blood coagulation inhibitor Disintegrin | 0.0264 | 0.0132 | 0.1643 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.0003 | 0.0043 |
Loa Loa (eye worm) | hypothetical protein | 0.0884 | 0.0766 | 1 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0183 | 0.0049 | 0.1429 |
Brugia malayi | Hemopexin family protein | 0.0263 | 0.0131 | 0.3014 |
Mycobacterium leprae | PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) | 0.9907 | 1 | 1 |
Onchocerca volvulus | Matrilysin homolog | 0.0412 | 0.0283 | 1 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0412 | 0.0283 | 1 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.378 | 0.373 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.0049 | 0.0639 |
Loa Loa (eye worm) | hypothetical protein | 0.0226 | 0.0093 | 0.1213 |
Trypanosoma brucei | Polypeptide deformylase 1 | 0.378 | 0.373 | 0.5 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.0226 | 0.0093 | 0.0044 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.0186 | 0.0051 | 0.1519 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.0003 | 0.0043 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.0049 | 0.0639 |
Echinococcus granulosus | adam 17 protease | 0.0463 | 0.0335 | 0.5681 |
Echinococcus granulosus | a disintegrin and metalloproteinase with | 0.0199 | 0.0065 | 0.0315 |
Schistosoma mansoni | hypothetical protein | 0.0263 | 0.0131 | 0.4319 |
Brugia malayi | Matrixin family protein | 0.0186 | 0.0051 | 0.0094 |
Brugia malayi | Matrixin family protein | 0.0186 | 0.0051 | 0.0094 |
Echinococcus multilocularis | Blood coagulation inhibitor, Disintegrin | 0.0264 | 0.0132 | 0.1643 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.378 | 0.373 | 0.5 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0675 | 0.0552 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.0003 | 0.0043 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.