Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | tachykinin receptor 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable lipoprotein aminopeptidase LpqL | 0.0012 | 0.0255 | 1 |
Echinococcus granulosus | glutaminyl peptide cyclotransferase | 0.0009 | 0 | 0.5 |
Trichomonas vaginalis | Clan MH, family M28, aminopeptidase S-like metallopeptidase | 0.0009 | 0 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0009 | 0 | 0.5 |
Brugia malayi | leucyl aminopeptidase | 0.0009 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0009 | 0 | 0.5 |
Onchocerca volvulus | Fxna peptidase homolog | 0.0009 | 0 | 0.5 |
Leishmania major | glutaminyl cyclase, putative | 0.0009 | 0 | 0.5 |
Brugia malayi | FXNA | 0.0009 | 0 | 0.5 |
Onchocerca volvulus | 0.0009 | 0 | 0.5 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0009 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.6401 | 0.6401 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0009 | 0 | 0.5 |
Onchocerca volvulus | Fxna peptidase homolog | 0.0009 | 0 | 0.5 |
Onchocerca volvulus | Fxna peptidase homolog | 0.0009 | 0 | 0.5 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0009 | 0 | 0.5 |
Schistosoma mansoni | NAALADASE L peptidase (M28 family) | 0.0086 | 0.6146 | 1 |
Mycobacterium ulcerans | lipoprotein aminopeptidase LpqL | 0.0012 | 0.0255 | 1 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0009 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0009 | 0 | 0.5 |
Onchocerca volvulus | Glutaminyl cyclase homolog | 0.0009 | 0 | 0.5 |
Toxoplasma gondii | peptidase, M28 family protein | 0.0009 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0009 | 0 | 0.5 |
Brugia malayi | nicalin | 0.0009 | 0 | 0.5 |
Echinococcus multilocularis | n acetylated alpha linked acidic dipeptidase 2 | 0.0132 | 0.9745 | 1 |
Trypanosoma brucei | glutaminyl cyclase, putative | 0.0009 | 0 | 0.5 |
Brugia malayi | Peptidase family M28 containing protein | 0.0009 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.905 | 0.905 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0009 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 14.3 nM | Binding affinity of the compound for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligand | ChEMBL. | 11277528 |
IC50 (binding) | = 14.3 nM | Binding affinity of the compound for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligand | ChEMBL. | 11277528 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.