Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | IMP (inosine 5'-monophosphate) dehydrogenase 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | adam 17 protease | 0.0187 | 0.0144 | 0.0144 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.2982 | 0.5908 | 0.9546 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.1638 | 0.3135 | 0.1477 |
Loa Loa (eye worm) | matrix metalloproteinase | 0.1345 | 0.2531 | 0.324 |
Loa Loa (eye worm) | hypothetical protein | 0.1638 | 0.3135 | 0.4238 |
Loa Loa (eye worm) | matrixin family protein | 0.2982 | 0.5908 | 0.8819 |
Loa Loa (eye worm) | matrixin family protein | 0.3329 | 0.6623 | 1 |
Brugia malayi | Matrixin family protein | 0.3329 | 0.6623 | 1 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.4967 | 1 | 1 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.1638 | 0.3135 | 0.5 |
Mycobacterium ulcerans | hydrolase | 0.1638 | 0.3135 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1345 | 0.2531 | 0.324 |
Schistosoma mansoni | hypothetical protein | 0.1907 | 0.3689 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1423 | 0.2691 | 0.3506 |
Onchocerca volvulus | 0.1907 | 0.3689 | 0.3275 | |
Echinococcus granulosus | adam 17 protease | 0.0206 | 0.0182 | 0.0182 |
Schistosoma mansoni | matrix metallopeptidase-9 (M10 family) | 0.0904 | 0.1622 | 0.4169 |
Loa Loa (eye worm) | hypothetical protein | 0.1345 | 0.2531 | 0.324 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.1638 | 0.3135 | 0.5 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.1423 | 0.2691 | 0.7185 |
Onchocerca volvulus | Matrilysin homolog | 0.306 | 0.6068 | 1 |
Brugia malayi | Hemopexin family protein | 0.1907 | 0.3689 | 0.2832 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 10 uM | In vitro inhibition of human lymphocyte proliferation in response to phytohaemagglutinin (PHA) was determined | ChEMBL. | 1967654 |
IC50 (functional) | > 10 uM | In vitro inhibition of human lymphocyte proliferation in response to pokeweed mitogen(PWM) was determined | ChEMBL. | 1967654 |
IC50 (functional) | > 10 uM | In vitro inhibition of human lymphocyte proliferation in response to staphylococcus protein A(SPA) was determined | ChEMBL. | 1967654 |
IC50 (binding) | = 10.9 uM | In vitro inhibition of inosine Inosine-5'-monophosphate dehydrogenase | ChEMBL. | 1967654 |
IC50 (binding) | = 10.9 uM | In vitro inhibition of inosine Inosine-5'-monophosphate dehydrogenase | ChEMBL. | 1967654 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.