Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED30 (functional) | = 43 mg kg-1 | Antiinflammatory activity was determined by inhibition of carrageenan-induced edema in rat paw with respect to phenylbutazone | ChEMBL. | 3572970 |
ED50 (functional) | = 1 mg kg-1 | Antiinflammatory activity was determined by inhibition of cotton pellet granuloma in rats with respect to Indomethacin | ChEMBL. | 3572970 |
ED50 (functional) | = 1 mg kg-1 | Antiinflammatory activity was determined by inhibition of adjuvant-induced arthritis in rats with respect to naproxen | ChEMBL. | 3572970 |
ED50 (functional) | = 250 mg kg-1 | Analgesic activity in mice by phenyl quinone-induced writhing assay with respect to aspirin. | ChEMBL. | 3572970 |
ED50 (functional) | = 250 mg kg-1 | Analgesic activity in mice by phenyl quinone-induced writhing assay with respect to aspirin. | ChEMBL. | 3572970 |
MED (functional) | = 1.7 mg kg-1 | Gastrointestinal erosive activity was determined by 7-day chronic assay in rats | ChEMBL. | 3572970 |
Therapeutic index (functional) | ~ 5 | Ratio of MED GI erosion to ED30 for carrageenan rat paw was determined | ChEMBL. | 3572970 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.