Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | protease, serine, 1 (trypsin 1) | Starlite/ChEMBL | References |
Homo sapiens | coagulation factor II (thrombin) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Trypsin family protein | protease, serine, 1 (trypsin 1) | 247 aa | 287 aa | 21.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0054 | 0.0234 | 0.1604 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0054 | 0.0234 | 0.1604 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.1184 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0054 | 0.0234 | 0.1979 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0063 | 0.0375 | 1 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0172 | 0.202 | 0.5 |
Brugia malayi | ecdysteroid receptor | 0.0054 | 0.0234 | 0.1604 |
Onchocerca volvulus | 0.0106 | 0.1027 | 0.867 | |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0172 | 0.202 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0054 | 0.0234 | 0.0194 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0054 | 0.0234 | 0.0194 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0234 | 0.1979 |
Mycobacterium tuberculosis | Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) | 0.045 | 0.6244 | 0.5 |
Onchocerca volvulus | 0.0054 | 0.0234 | 0.1979 | |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0054 | 0.0234 | 0.1979 |
Leishmania major | polypeptide deformylase-like protein, putative | 0.0172 | 0.202 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0054 | 0.0234 | 0.1604 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0054 | 0.0234 | 0.1979 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0054 | 0.0234 | 0.0194 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0054 | 0.0234 | 0.1604 |
Schistosoma mansoni | thyroid hormone receptor | 0.0054 | 0.0234 | 0.0194 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0234 | 0.1979 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0054 | 0.0234 | 0.1604 |
Schistosoma mansoni | thyroid hormone receptor | 0.0054 | 0.0234 | 0.0194 |
Schistosoma mansoni | coup transcription factor | 0.0054 | 0.0234 | 0.0194 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0054 | 0.0234 | 0.1604 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0234 | 0.1979 |
Brugia malayi | Trypsin family protein | 0.0117 | 0.1184 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0054 | 0.0234 | 0.1604 |
Trypanosoma brucei | Peptide deformylase 2 | 0.0172 | 0.202 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0234 | 0.1979 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0054 | 0.0234 | 0.1979 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0054 | 0.0234 | 0.0194 |
Schistosoma mansoni | nuclear hormone receptor | 0.0054 | 0.0234 | 0.0194 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0054 | 0.0234 | 0.1604 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0054 | 0.0234 | 0.0194 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0054 | 0.0234 | 0.0194 |
Loa Loa (eye worm) | matrixin family protein | 0.0042 | 0.0053 | 0.0447 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0054 | 0.0234 | 0.1604 |
Trypanosoma brucei | Polypeptide deformylase 1 | 0.0172 | 0.202 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0054 | 0.0234 | 0.1979 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0234 | 0.1979 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0054 | 0.0234 | 0.1979 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0054 | 0.0234 | 0.1604 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.1184 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0054 | 0.0234 | 0.1979 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0054 | 0.0234 | 0.0194 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0054 | 0.0234 | 0.1604 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0054 | 0.0234 | 0.1604 |
Onchocerca volvulus | 0.0117 | 0.1184 | 1 | |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0054 | 0.0234 | 0.0194 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0054 | 0.0234 | 0.1979 |
Brugia malayi | nuclear hormone receptor | 0.0054 | 0.0234 | 0.1604 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0234 | 0.1979 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0054 | 0.0234 | 0.1604 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0234 | 0.1979 |
Mycobacterium ulcerans | peptide deformylase | 0.045 | 0.6244 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0054 | 0.0234 | 0.1604 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0054 | 0.0234 | 0.1979 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0117 | 0.1184 | 0.1148 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0054 | 0.0234 | 0.1979 |
Brugia malayi | steroid hormone receptor | 0.0054 | 0.0234 | 0.1604 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0172 | 0.202 | 0.5 |
Mycobacterium leprae | PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) | 0.045 | 0.6244 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.045 | 0.6244 | 0.5 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0063 | 0.0375 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0054 | 0.0234 | 0.1604 |
Plasmodium falciparum | peptide deformylase | 0.045 | 0.6244 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0054 | 0.0234 | 0.1604 |
Treponema pallidum | polypeptide deformylase (def) | 0.045 | 0.6244 | 0.5 |
Plasmodium vivax | peptide deformylase, putative | 0.045 | 0.6244 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | peptide deformylase | 0.045 | 0.6244 | 0.5 |
Chlamydia trachomatis | peptide deformylase | 0.045 | 0.6244 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0117 | 0.1184 | 0.1148 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0172 | 0.202 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0054 | 0.0234 | 0.1604 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0054 | 0.0234 | 0.0194 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0054 | 0.0234 | 0.1979 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0234 | 0.1979 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2050 nM | Inhibition of human Thrombin | ChEMBL. | 10206546 |
IC50 (binding) | = 2050 nM | Inhibition of human Thrombin | ChEMBL. | 10206546 |
IC50 (binding) | = 8490 nM | In vitro inhibitory activity against human trypsin | ChEMBL. | 10206546 |
IC50 (binding) | = 8490 nM | In vitro inhibitory activity against human trypsin | ChEMBL. | 10206546 |
Selectivity (binding) | = 4 | Selectivity ratio for trypsin and thrombin (FIIa) | ChEMBL. | 10206546 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.