Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | SUMO activating enzyme subunit 2 | 0.0057 | 1 | 0.5 |
Giardia lamblia | Ubiquitin-activating enzyme E1 1 | 0.0024 | 0 | 0.5 |
Entamoeba histolytica | ubiquitin-activating enzyme, putative | 0.0024 | 0 | 0.5 |
Trypanosoma brucei | ubiquitin-activating enzyme E1, putative | 0.0057 | 1 | 0.5 |
Plasmodium falciparum | SUMO-activating enzyme subunit 2 | 0.0057 | 1 | 0.5 |
Echinococcus granulosus | sumo-activating enzyme subunit 2 | 0.0057 | 1 | 0.5 |
Schistosoma mansoni | ubiquitin-activating enzyme E1b | 0.0057 | 1 | 0.5 |
Toxoplasma gondii | ThiF family protein | 0.0057 | 1 | 0.5 |
Trypanosoma cruzi | ubiquitin-activating enzyme, putative | 0.0057 | 1 | 1 |
Leishmania major | ubiquitin-activating enzyme-like protein | 0.0057 | 1 | 0.5 |
Plasmodium vivax | SUMO-activating enzyme subunit 2, putative | 0.0057 | 1 | 0.5 |
Loa Loa (eye worm) | ThiF family protein | 0.0057 | 1 | 0.5 |
Trypanosoma cruzi | ubiquitin-activating enzyme, putative | 0.0054 | 0.9115 | 0.9115 |
Trichomonas vaginalis | molybdopterin biosynthesis moeb protein, putative | 0.0024 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 40 uM | Inhibition of EGF-stimulated DNA synthesis in ER 22 (EGF-receptor expressing) cells | ChEMBL. | 8145236 |
IC50 (functional) | = 40 uM | Inhibition of EGF-stimulated DNA synthesis in ER 22 (EGF-receptor expressing) cells | ChEMBL. | 8145236 |
IC50 (functional) | = 50 uM | Inhibitory potency against protein tyrosine kinase activity associated with EGFR was evaluated using ER 22 cell membrane | ChEMBL. | 8145236 |
IC50 (functional) | = 50 uM | Inhibitory potency against protein tyrosine kinase activity associated with EGFR was evaluated using ER 22 cell membrane | ChEMBL. | 8145236 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.